Results 231 to 240 of about 113,519 (282)

Relapse and Neurological Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease: A Retrospective Secondary Analysis of a Japanese Nationwide Epidemiologic Survey

Clinical and Experimental Neuroimmunology, Volume 17, Issue 2, May 2026.
ABSTRACT Background Some patients with myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) experience multiple relapses and poor prognoses; however, the factors associated with these outcomes are unclear. This study aimed to identify factors associated with relapse and neurological prognosis in patients with MOGAD.
Masashi Nakamura, Juichi Fujimori, Akiyuki Uzawa, Satoshi Kuwabara, Ichiro Nakashima   +4 more
wiley   +1 more source

Rational Design of Nanobodies Targeting LINGO‐1

Applied Research, Volume 5, Issue 2, April 2026.
We rationally designed and recombinantly produced a panel of single‐domain antibodies (nanobodies) targeting the human transmembrane protein LINGO‐1, a key player in multiple sclerosis. ABSTRACT The leucine‐rich repeat and immunoglobulin‐like domain‐containing Nogo receptor‐interacting protein 1 (LINGO‐1) is a transmembrane protein expressed in neurons
Alexander Röntgen, Vaidehi Roy Chowdhury, Aubin Ramon, Matthew Greenig, Xing Xu, Pietro Sormanni, Michele Vendruscolo   +6 more
wiley   +1 more source

Sildenafil reduced neuroinflammation and improved white matter injury in a rat model of term neonatal hypoxic-ischemic encephalopathy. [PDF]

Sci Rep
Yazdani A, Bleau V, Song R, Zheng Y, Balian P, Khoja Z, Chevin M, Wintermark P.   +7 more
europepmc   +1 more source

Blood Serum From Obese Women Raises ROS Production by Neural Stem Cells

Developmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT Maternal obesity has been associated with adverse pregnancy outcomes and altered fetal development, but the direct influence of circulating maternal factors on early human neural cells remains poorly understood. Neural stem cells (NSCs) provide a controlled system to examine how metabolic and inflammatory changes may affect early ...
Phelipe Elias da Silva, Natássia Caroline Resende Corrêa, Natália Ferreira Silva, Carlos Ueira‐Vieira, Hebreia Oliveira Almeida‐Souza, Mario Machado Martins, Tiara da Costa Silva, Renata Graciele Zanon   +7 more
wiley   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Mycobacterium tuberculosis-induced oligodendrocyte apoptosis promotes astrocyte-mediated cell-in-cell formation and phagocytosis in tuberculous meningitis. [PDF]

BMC Infect Dis
Feng J, Qiu F, Niu Z, Fang M, Yang J, Xiao L, Zhao J, Sun Q, Zhang J.   +8 more
europepmc   +1 more source

Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel‐Wise Multimodal MRI Study

Journal of Magnetic Resonance Imaging, Volume 63, Issue 4, Page 1053-1066, April 2026.
ABSTRACT Background Autism Spectrum Disorder (ASD) presents with early neurodevelopmental alterations in preschool children, yet comprehensive characterization using multimodal quantitative MRI remains limited in this age group. Purpose To investigate voxel‐wise brain microstructural differences in preschool ASD through integrated analysis of cerebral ...
Changhao Wang, Meiying Cheng, Yu Lu, Jinxia Guo, Xueyan Liu, Zhanqi Feng, Shipeng Liu, Xin Zhao   +7 more
wiley   +1 more source

Brain lipid profiles and oligodendrocyte gene expression show discordant responses to high-fat diet in Alzheimer's disease mice. [PDF]

Sci Rep
Kawade N, Komine O, Sobue A, Kakimi C, Tanaka M, Suganami T, Shimada M, Ogi T, Ikeda K, Horiuchi M, Watanabe S, Saito T, Yamanaka K.   +12 more
europepmc   +1 more source

Mapping Intracellular Volume Fraction With Susceptibility Source Decomposition as a Marker for Tissue Cellularity

Journal of Magnetic Resonance Imaging, Volume 63, Issue 4, Page 1092-1105, April 2026.
ABSTRACT Background Pathophysiological changes affect tissue cell composition and density. For example, neurodegenerative disorders and brain tumors are associated with cell loss and abnormal accumulation, respectively. In these scenarios, if monitored and tracked, tissue cellularity might be used to inform clinical diagnosis and management. Purpose To
Giulia Debiasi, Oliver C. Kiersnowski, Giovanni Librizzi, Luca Roccatagliata, Renzo Manara, Mauro Costagli, Alessandra Bertoldo, Chunlei Liu   +7 more
wiley   +1 more source

Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery. [PDF]

Front Immunol
Gong X, Feng J, Xu Z, Xie Y, Han Y, Li J, Tang G, Liu Y, Dong X, Li S, Zhang J, Wang J, Liu R, Song J, Bi H.   +14 more
europepmc   +1 more source