Results 231 to 240 of about 81,187 (302)

Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury. [PDF]

open access: yesCell
Xu YKT   +10 more
europepmc   +1 more source

Quantitative MRI Biomarkers of Myelin: Cross‐Validation and Diagnostic Performance in Multiple Sclerosis

open access: yesNMR in Biomedicine, Volume 39, Issue 7, July 2026.
STAIR‐UTE, STAIR‐STE, and MT‐derived myelin biomarkers (MPF, MWF, MMF, MTR) strongly correlate in WM, gray matter, and MS lesions. All distinguish normal from abnormal tissue, though subtle differences suggest complementary information. Histological validation is needed to confirm specificity.
James Lo   +7 more
wiley   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

open access: yesBrain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong   +8 more
wiley   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

open access: yesBrain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato   +15 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling. [PDF]

open access: yesStem Cell Rev Rep
Ahuja K   +23 more
europepmc   +1 more source

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