Results 111 to 120 of about 17,381 (266)

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Movement Disorders, Volume 40, Issue 5, Page 950-961, May 2025.
Abstract Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To investigate the association between CNVs and structural forms on 17q.21.31 with the risk of PSP.
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po‐Liang Cheng, Ya‐Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente‐Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina‐Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano‐Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili‐Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivianna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw R. Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yaroslau Compta, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li‐San Wang, PSP Genetics Study Group, Anthony E. Lang, Murray Grossman, David S. Knopman, Lon S. Schneider, Rachelle S. Doody, Andrew Lees, Lawrence I. Golbe, David R. Williams, Jean‐Cristophe Corvol, Albert Ludolph, David Burn, Stefan Lorenzl, Erik D. Roberson, Mary Koestler, Clifford R. Jack Jr, Christopher Randolph, Iryna V. Lobach, Hilary W. Heuer, Illana Gozes, Lesley Parker, Steve Whitaker, Joe Hirman, Alistair J. Stewart, Michael Gold, Bruce H. Morimoto, Jochen Herms, Ellen Gelpi, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Jung‐Ying Tzeng, Daniel H. Geschwind, Gerard D. Schellenberg, Wan‐Ping Lee   +93 more
wiley   +1 more source

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

Molecular Neurobiology, 2015
Oligodendrocytes, the myelinating cells of the central nervous system, mediate rapid action potential conduction and provide trophic support for axonal as well as neuronal maintenance.
Benjamin Ettle, J. Schlachetzki, J. Winkler   +2 more
semanticscholar   +1 more source

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

Stem Cell Reports, 2019
Summary: The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain.
Hyosung Kim, Ranjie Xu, Ragunathan Padmashri, Anna Dunaevsky, Ying Liu, Cheryl F. Dreyfus, Peng Jiang   +6 more
doaj  

Mitochondria‐Associated Membranes: A Key Point of Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
ABSTRACT Background Neurodegenerative diseases pose significant health challenges in the 21st century, with increasing morbidity and mortality, particularly among the elderly population. One of the key factors contributing to the pathogenesis of these diseases is the disrupted crosstalk between mitochondria and the endoplasmic reticulum.
Yiwei Zhang, Xiuqin Rao, Jiayi Wang, Hantian Liu, Qixian Wang, Xifeng Wang, Fuzhou Hua, Xilong Guan, Yue Lin   +8 more
wiley   +1 more source

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Acta Neuropathologica Communications, 2017
Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel, David J. Marmion, Deniz Kirik, Yaping Chu, Clifford Heindel, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower   +7 more
doaj   +1 more source

Identification of Radial Glia-like Cells in the Adult Mouse Olfactory Bulb [PDF]

, 2012
Immature neurons migrate tangentially within the rostral migratory stream (RMS) to the adult olfactory bulb (OB), then radially to their final positions as granule and periglomerular neurons; the controls over this transition are not well understood ...
Emsley, Jason G., Macklis, Jeffrey Daniel, Madeiro Da Costa, Rodrigo F., Martinez, Ana Maria Blanco, Menezes, João R.L.   +4 more
core   +1 more source

Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development

Translational Psychiatry, 2017
Neuropsychiatric disorders, represented by schizophrenia, affect not only neurons but also myelinating oligodendroglia (OL), both contribute to the complex etiology.
Xianjun Chen, Li Ku, R. Mei, Guanglu Liu, Chongchong Xu, Z. Wen, Xiaofeng Zhao, Fei Wang, L. Xiao, Yue Feng   +9 more
semanticscholar   +1 more source

Pozícionális gének aktivitásának szerepe az idegsejt-fenotípus meghatározásában = Role of positional genes in the determination of the neuronal phenotype [PDF]

, 2012
A jellegzetes mintázatban aktiválódó pozícionális gének agyfejlődésben játszott szerepét vizsgálva az alábbi eredményeket nyertük: 1. A korai NE-4C embrionális idegi őssejtek indukálatlan állapotban regionálisan nem elkötelezettek; a neuron-képzés ...
Demeter, Kornél, Herberth, Balázs, Hádinger, Nóra, Környei, Zsuzsanna, Madarász, Emília, Markó, Károly, Varga, Balázs Viktor, Zádori, Anita   +7 more
core  

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected [PDF]

, 2017
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are
Barnett, Susan C., Barrie, Jennifer A., Brennan, Benjamin, Cumberworth, Stephanie L., Cunningham, Madeleine E., de Oliveira França, Rafael Freitas, Edgar, Julia M., Gomes de Figueiredo, Daniely Paulino, Kohl, Alain, Linington, Christopher, Pena, Lindomar J., Schultz, Verena, Wilder-Smith, Adrian J., Willison, Hugh J.   +13 more
core   +1 more source

Blood exosome connexins and small RNAs related to demyelinating disease activity

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 538-555, March 2025.
Abstract Objectives To assess blood exosome (Ex)‐connexin (Cx)43 (encoded by GJA1) and its truncated isoforms in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), which show distinct alterations in astroglial Cx43. Methods Serum Exs from 48 patients with MS (34 relapsing–remitting, 14 secondary‐progressive), 35 with NMOSD, 20 ...
Guzailiayi Maimaitijiang, Jun‐ichi Kira, Yuri Nakamura, Mitsuru Watanabe, Ezgi Ozdemir Takase, Satoshi Nagata, Ayako Sakoda, Xu Zhang, Katsuhisa Masaki, Ryo Yamasaki, Noriko Isobe, Hiroo Yamaguchi, Tomohiro Imamura   +12 more
wiley   +1 more source