Results 11 to 20 of about 15,075 (153)

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression. [PDF]

Glia
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Peiró-Moreno C, Chara JC, Marshall-Phelps K, Ugarte-Arakistain I, Calovi S, De Almeida RG, Domercq M, Matute C.   +7 more
europepmc   +3 more sources

Oligodendroglial Densities and Myelin Structure Are Altered in TDP-43 Related Amyotrophic Lateral Sclerosis. [PDF]

Glia
TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Lewis KN, Craig GA, Mason J, Tomas D, Cuic B, Walker AK, Gonsalvez DG, Turner BJ, Barton SK.   +8 more
europepmc   +2 more sources

Chromatin remodelers in oligodendroglia [PDF]

Glia, 2020
AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras, Corentine Marie, Chuntao Zhao, Qing Richard Lu   +3 more
openaire   +3 more sources

Distinct patterns of oligodendroglial dysfunction in neurodegenerative diseases [PDF]

Alzheimers Dement
Abstract Background Oligodendroglia are a major class of glial cell that play critical roles in myelination and neuronal support. Involvement of oligodendroglia is well‐known pathologically in frontotemporal lobar degeneration with tau (FTLD‐tau) and TDP‐43 (FTLD‐TDP) pathology, Alzheimer's disease (AD) and multiple system atrophy (MSA). However, their
Forrest S, Kane M, Knott S, Kovacs G.
europepmc   +2 more sources

The next generation of spatial transcriptomics and AI to understand complex interactions between glial cells [PDF]

Alzheimers Dement
Abstract Emerging research highlights the significant contributions of non‐neuronal cells—astrocytes, microglia, and oligodendrocytes—in Alzheimer's disease (AD). These glial cells are not only implicated in neuroinflammation, synaptic dysfunction, and neurodegeneration but also engage in highly dynamic crosstalk that modulates key pathological ...
Das S.
europepmc   +2 more sources

Identification of candidate causal risk genes and pathways in Alzheimer's disease and Lewy body dementia [PDF]

Alzheimers Dement
Abstract Background The neurodegenerative disorders Alzheimer's disease (AD) and Lewy body dementia (LBD) share genetic and clinicopathological overlap and may constitute a disease spectrum. Common variant genome‐wide association studies (GWASs) have uncovered AD and LBD etiology.
Picarello D, Adams D, Patel T, Fulton‐Howard B, Chia R, Comertpay B, Goate A, Kozlenkov A, Dracheva S, Traynor B, Scholz S, Marcora E, Renton A.   +12 more
europepmc   +2 more sources

A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP-43 Pathology. [PDF]

Neuropathol Appl Neurobiol
Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
Matsubara T, Izumi Y, Hatanaka Y, Takahara M, Kondo A, Matsukura K, Arakawa A, Haga T, Miyamoto R, Naruse H, Morino H, Toda T, Murayama S, Saito Y.   +13 more
europepmc   +2 more sources

Oligodendroglia: metabolic supporters of axons [PDF]

Trends in Cell Biology, 2013
Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary.
Brett M, Morrison, Youngjin, Lee, Jeffrey D, Rothstein   +2 more
openaire   +2 more sources

Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. [PDF]

, 2019
CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well as enhancement of the migration, proliferation, and myelin production by oligodendroglia. Using an
Cheng, Yuting, Dickey, Laura L, Eckman, Emily, Grist, Jonathan J, Lane, Thomas E, Liu, Liping, Marro, Brett S, Ransohoff, Richard M, Skinner, Dominic D, Stone, Colleen   +9 more
core   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources