Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
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SIRT2, tubulin deacetylation, and oligodendroglia differentiation [PDF]
AbstractThe mammalian silent information regulator 2 (SIRT2) is an NAD‐dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles in regulating cytoplasmic microtubule dynamics were unknown.
Bor Luen, Tang, Christelle En Lin, Chua
openaire +2 more sources
Chronic alcohol abuse is implicated in the oxidative stress and the changes in the neurotrophic factor receptor expression in the human CNS [PDF]
Alcohol abuse and alcoholism induce brain damage, and, in some cases, neurodegeneration. The pathogenesis of the alcohol-induced injury of the CNS is a complex process in which oxidative stress plays an essential role.
Groma, V., Kleina, R., Skuja, Sandra
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Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy [PDF]
Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers.
Chari, DM +6 more
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Pathology of oligodendroglia: An overview [PDF]
Oligodendroglia are cells responsible for creating myelin sheaths for axons in the CNS. However, pathologies of oligodendroglia other than demyelination are not well understood due to the lack of adequate methods of characterizing pathological conditions affecting oligodendroglia in human tissue. This review discusses three major topics with the aim of
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Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia [PDF]
Background Magnetic nanoparticles (MNPs) offer a large range of applications in life sciences. Applications in neurosciences are one focus of interest. Unfortunately, not all groups have access to nanoparticles or the possibility to develop and produce ...
Pinkernelle Josephine +4 more
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Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α [PDF]
The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air.
Brill, Christina +4 more
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Oligodendroglia and neurotrophic factors in neurodegeneration
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the myelin sheath also protects axons against inflammatory and oxidative insults. Loss of myelin results in axonal damage and ultimately
Andrew N, Bankston +2 more
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Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination. [PDF]
We have investigated the expression of integrins by rat oligodendroglia grown in primary culture and the functional role of these proteins in myelinogenesis.
Malek-Hedayat, S, Rome, LH
core
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats [PDF]
Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we
Atanur, Santosh S. +12 more
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