Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
, 2006 Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
core +1 more source
SIRT2, tubulin deacetylation, and oligodendroglia differentiation [PDF]
Cell Motility, 2007 AbstractThe mammalian silent information regulator 2 (SIRT2) is an NAD‐dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles in regulating cytoplasmic microtubule dynamics were unknown.
Bor Luen, Tang, Christelle En Lin, Chua
openaire +2 more sources
Chronic alcohol abuse is implicated in the oxidative stress and the changes in the neurotrophic factor receptor expression in the human CNS [PDF]
, 2011 Alcohol abuse and alcoholism induce brain damage, and, in some cases, neurodegeneration. The pathogenesis of the alcohol-induced injury of the CNS is a complex process in which oxidative stress plays an essential role.
Groma, V., Kleina, R., Skuja, Sandra
core +3 more sources
Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy [PDF]
, 2014 Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers.
Chari, DM +6 more
core +2 more sources
Pathology of oligodendroglia: An overview [PDF]
Neuropathology, 2017 Oligodendroglia are cells responsible for creating myelin sheaths for axons in the CNS. However, pathologies of oligodendroglia other than demyelination are not well understood due to the lack of adequate methods of characterizing pathological conditions affecting oligodendroglia in human tissue. This review discusses three major topics with the aim of
openaire +2 more sources
Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia [PDF]
, 2012 Background Magnetic nanoparticles (MNPs) offer a large range of applications in life sciences. Applications in neurosciences are one focus of interest. Unfortunately, not all groups have access to nanoparticles or the possibility to develop and produce ...
Pinkernelle Josephine +4 more
core +1 more source
Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α [PDF]
, 2017 The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air.
Brill, Christina +4 more
core +2 more sources
Oligodendroglia and neurotrophic factors in neurodegeneration
Neuroscience Bulletin, 2013 Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the myelin sheath also protects axons against inflammatory and oxidative insults. Loss of myelin results in axonal damage and ultimately
Andrew N, Bankston +2 more
openaire +3 more sources
Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination. [PDF]
, 1994 We have investigated the expression of integrins by rat oligodendroglia grown in primary culture and the functional role of these proteins in myelinogenesis.
Malek-Hedayat, S, Rome, LH
core
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats [PDF]
, 2018 Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we
Atanur, Santosh S. +12 more
core +3 more sources