Results 11 to 20 of about 15,473 (242)

Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury. [PDF]

J Neuropathol Exp Neurol
Ruscher K, Michalettos G, Abu Hamdeh S, Clausen F, Nolan AL, Flygt J, Özen I, Marklund N.   +7 more
europepmc   +2 more sources

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Ramirez AM, Nasciben LB, Moura S, Coombs L, Rajabli F, DeRosa BA, Whitehead PL, Adams LD, Starks TD, Mena PR, Illanes-Manrique M, Tejada S, Byrd GS, Caban-Holt A, Cuccaro ML, McInerney K, Cornejo-Olivas MR, Feliciano-Astacio BE, Wang L, Robayo MC, Xu W, Jin F, Pericak-Vance MA, Griswold AJ, Young JI, Dykxhoorn DM, Vance JM.   +26 more
europepmc   +2 more sources

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy [PDF]

, 2014
Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki, Shizuko Ichinose, Akiyoshi Kakita, Mari Tada, Hitoshi Takahashi, Noboru Ando, Yoshinobu Eishi, Hidehiro Mizusawa, Kinya Ishikawa   +10 more
openalex   +3 more sources

A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP-43 Pathology. [PDF]

Neuropathol Appl Neurobiol
Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
Matsubara T, Izumi Y, Hatanaka Y, Takahara M, Kondo A, Matsukura K, Arakawa A, Haga T, Miyamoto R, Naruse H, Morino H, Toda T, Murayama S, Saito Y.   +13 more
europepmc   +2 more sources

Myelin Lipid Composition in the Central Nervous System Is Regionally Distinct and Requires Mechanistic Target of Rapamycin Signaling. [PDF]

Glia
Main Points Brain oligodendrocytes have lower rates of cholesterol synthesis and higher rates of lipoprotein uptake than spinal cord oligodendrocytes. Myelin lipid content is higher in CNS regions with larger average axon diameter. Brain and spinal cord myelin cholesterol content is innately different, while myelin fatty acid content can be modulated ...
Mather ML, Evangelou AV, Bourne JN, Macklin WB, Wood TL.   +4 more
europepmc   +2 more sources

Beyond Myelination: Possible Roles of the Immune Proteasome in Oligodendroglial Homeostasis and Dysfunction

Frontiers in Neuroscience, 2022
Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira, Miguel M. Madeira, Miguel M. Madeira, Zachary Hage, Zachary Hage, Stella E. Tsirka, Stella E. Tsirka, Stella E. Tsirka   +7 more
doaj   +1 more source

Chromatin remodelers in oligodendroglia [PDF]

Glia, 2020
AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras, Corentine Marie, Chuntao Zhao, Qing Richard Lu   +3 more
openaire   +4 more sources

Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Life, 2021
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
doaj   +1 more source

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes [PDF]

Diabetes & Metabolism Journal, 2022
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis.
Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou   +3 more
doaj   +1 more source

DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice

Frontiers in Neuroscience, 2021
Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia.
Xianjun Chen, Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Xing-Shu Chen, Lan Xiao   +8 more
doaj   +1 more source