A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome [PDF]
Acta Neuropathologica CommunicationsWolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
K. Ahuja +27 more
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Diagnostic Insighhts Into JC Virus–Infected Glial Cells: Intraoperative Cytopathological Analysis of Dot‐Shaped Inclusions Associated With PML‐NBs [PDF]
Cytopathology, Volume 36, Issue 3, Page 281-284, May 2025.This is the first case report describing the diagnostic value of dot‐shaped inclusions associated with promyelocytic leukaemia nuclear bodies (PML‐NBs) to define JC virus–infected glial cells in an intraoperative cytopathological diagnosis for progressive multifocal leukoencephalopathy (PML).
Nobuko Ujihira +2 more
wiley +2 more sources
MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis [PDF]
eLife, 2023 Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.
Em P Harrington +8 more
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A quantitative analysis of bestrophin 1 cellular localization in mouse cerebral cortex [PDF]
Acta Physiologica, Volume 241, Issue 1, January 2025.Abstract Aim Calcium‐activated ligand‐gated chloride channels, beyond their role in maintaining anion homeostasis, modulate neuronal excitability by facilitating nonvesicular neurotransmitter release. BEST1, a key member of this family, is permeable to γ‐aminobutyric acid (GABA) and glutamate.
Michael Di Palma +3 more
wiley +2 more sources
Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits
Nature Communications, 2020 Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer +3 more
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Autophagy in α-Synucleinopathies—An Overstrained System
Cells, 2021 Alpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Lisa Fellner +3 more
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Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers
Cells, 2021 During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons ...
Ana Cristina Ojalvo-Sanz +1 more
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Oligodendroglia: metabolic supporters of axons [PDF]
Trends in Cell Biology, 2013 Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary.
Jeffrey D. Rothstein +2 more
openaire +3 more sources
Glioneuronal apoptosis and neuroinflammation in drug resistant temporal lobe epilepsy
Неврология, нейропсихиатрия, психосоматика, 2023 The study of glioneuronal apoptosis and neuroinflammation is extremely important for understanding the causes of epilepsy. Currently, the focus is on neuronal apoptosis and certain aspects of neuroinflammation, while glial apoptosis remains poorly ...
T. V. Sokolova +9 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the
Mohanlall Narine +5 more
doaj +1 more source