Results 11 to 20 of about 15,454 (234)
Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method [PDF]
, 2000 The phosphoramidite approach has had a major impact on the synthesis of oligonucleotides. This unit describes parameters that affect the performance of this method for preparing oligodeoxyribonucleotides, as well as a number of compatible strategies ...
Anonymous +8 more
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A Solution to the Common Problem of the Synthesis and Applications of Hexachlorofluorescein Labeled Oligonucleotides. [PDF]
PLoS ONE, 2016 A common problem of the preparation of hexachlorofluorescein labeled oligonucleotides is the transformation of the fluorophore to an arylacridine derivative under standard ammonolysis conditions. We show here that the arylacridine byproduct with distinct
Andrey N Chuvilin +4 more
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Pathogens, 2021 Mimicking bacterial DNA, synthetic CpG-containing oligodeoxyribonucleotides (CpG-ODNs) have a powerful immunomodulatory potential. Their practical application is mainly associated with the production of vaccines, where they are used as adjuvants, as well
Ekaterina A. Golenkina +5 more
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ChemPhotoChem, Volume 7, Issue 12, December 2023., 2023 The photoreaction of a styrylpyridine derivative leads to a DNA‐binding benzoquinolizinium derivative with selectivity towards abasic site‐containing DNA (AP‐DNA), as caused by the sterically demanding substituents. Notably, the DNA binding is accomplished by photoinduced in situ formation of the ligand in the presence of AP‐DNA.
Julika Schlosser +3 more
wiley +1 more source
The Journal of Gene Medicine, Volume 25, Issue 11, November 2023., 2023 Cancer is a heterogeneous and complex disease in which some cells in the body proliferate uncontrollably and invade other tissues and individual differences are quite effective. Treatment using advanced therapy medicinal products, one of which is gene therapy, is gaining importance by the develeopment of biotechnology. Gene therapy strategies in cancer
Büşra Cesur‐Ergün +1 more
wiley +1 more source
Anomalous hairpin formation in an oligodeoxyribonucleotide [PDF]
Nucleic Acids Research, 1985 An accurate method for deriving molar absorptivity-temperature profiles applied to a set of single-stranded oligodeoxyribonucleotides shows that the undecamer CGAGTTTGACGp exists in a hairpin conformation involving Watson-Crick base pairing between the two terminal CG dinucleotides.
P.T. Gilham, J.G. Nadeau
openaire +3 more sources
DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site [PDF]
, 2009 20 pages, 7 figures, 1 table.-- PMID: 19467223 [PubMed].-- PMCID: PMC2756644.-- NIHMSID: NIHMS130041.-- Printed version published Sep 15, 2009.Aberrant cytosine methylation in promoter regions leads to gene silencing associated with cancer progression. A
Van Bemmel, Dana M. +4 more
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Clinical and Translational Science, Volume 16, Issue 7, Page 1272-1282, July 2023., 2023 Abstract RO7062931 is an N‐acetylgalactosamine (GalNAc)‐conjugated single‐stranded oligodeoxyribonucleotide complementary to hepatitis B virus RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This phase I single ascending dose (SAD) study evaluated the safety, tolerability, and pharmacokinetics of RO7062931 in ...
Tsang Tommy Cheung +8 more
wiley +1 more source
Rainbow™ Universal CPG: A Versatile Solid Support for Oligonucleotide Synthesis
BioTechniques, 1997 We have developed a universal solid support, termed Rainbow™ Universal CPG, for use in automated oligonucleotide synthesis. The universal solid support allows any oligodeoxyribonucleotide sequence to be synthesized from a single type of controlled pore ...
P.S. Nelson +4 more
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Вавиловский журнал генетики и селекции, 2022 Modern approaches to the detection and analysis of low-copy-number RNAs are often based on the use of RNA-dependent DNA polymerases, for example, in reverse-transcription PCR.
E. S. Dyudeeva, I. A. Pyshnaya
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