Results 21 to 30 of about 4,788 (197)
Вавиловский журнал генетики и селекции, 2023 To date, many derivatives and analogs of nucleic acids (NAs) have been developed. Some of them have found uses in scientific research and biomedical applications. Their effective use is based on the data about their properties. Some of the most important
I. I. Yushin +3 more
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hnRNP A2, a Potential ssDNA/RNA Molecular Adapter at the Telomere [PDF]
, 2005 The heterogeneous nuclear ribonucleoprotein (hnRNP) A2 is a multi-tasking protein that acts in the cytoplasm and nucleus. We have explored the possibility that this protein is associated with telomeres and participates in their maintenance.
Moran-Jones, Kim +6 more
core +1 more source
Determination of Methylation Site of DNA-Methyltransferase NlaX by a Hybrid Method
BioTechniques, 2002 Using a new method based on a combination of bisulfite reaction, the repair enzyme uracil-DNA glycosylase, and synthetic oligodeoxyribonucleotides, the methylation site of DNA-methyltransferase NlaX (M·NlaX) from Neisseria lactamica was established to be
E.A. Kubareva +5 more
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Вавиловский журнал генетики и селекции, 2022 The GRIN1, ASCL3, and NOS1 genes are associated with various phenotypes of neuropsychiatric disorders. For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy.
E. B. Sharypova +4 more
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Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides
Molecules, 2013 The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed.
Tatyana Abramova
doaj +1 more source
Design of an N^7-Glycosylated Purine Nucleoside for Recognition of GC Base Pairs by Triple Helix Formation [PDF]
, 1995 Pyrimidine oligodeoxyribonucleotides bind in the major groove of DNA parallel to the purine Watson-Crick strand by formation of specific hydrogen bonds between thymine and adenine (T•AT triplet) and protonated cytosine and guanine (C+GC triplet) on the ...
Brunar, Helmut +3 more
core +2 more sources
Molecules, 2015 The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation.
Jolanta Brzezinska +1 more
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Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics
Molecules, 2020 Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies the ...
Oleg V. Markov +9 more
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Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines [PDF]
, 1996 A powerful and potentially general approach to the targeting and crystallization of proteins on lipid interfaces through coordination of surface histidine residues to lipid-chelated divalent metal ions is presented.
Arnold, Frances H. +7 more
core +1 more source
Vortex fluidics-mediated DNA rescue from formalin-fixed museum specimens. [PDF]
, 2020 DNA from formalin-preserved tissue could unlock a vast repository of genetic information stored in museums worldwide. However, formaldehyde crosslinks proteins and DNA, and prevents ready amplification and DNA sequencing.
Girguis, Peter R +6 more
core +1 more source