Characterization of Gastrointestinal Absorption of Salmon Milt-Derived Oligodeoxyribonucleic Acids in Mice [PDF]
Journal of Nutrition and MetabolismDietary nucleic acids exert physiological effects beyond serving as substrates for nucleic acid synthesis; however, their exact molecular forms that are absorbed in the small intestine remain unclear.
Fuyu Hayashi +8 more
doaj +3 more sources
Hydrolysis of Oligodeoxyribonucleotides on the Microarray Surface and in Solution by Catalytic Anti-DNA Antibodies in Systemic Lupus Erythematosus [PDF]
Current Issues in Molecular Biology, 2023 Anti-DNA antibodies are known to be classical serological hallmarks of systemic lupus erythematosus (SLE). In addition to high-affinity antibodies, the autoantibody pool also contains natural catalytic anti-DNA antibodies that recognize and hydrolyze DNA.
Tatiana S. Novikova +6 more
doaj +2 more sources
Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides
Molecules, 2013 The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed.
Tatyana Abramova
doaj +2 more sources
Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells [PDF]
Scientific ReportsSingle-stranded oligodeoxyribonucleotide (ssODN) gene editing has emerged as a promising therapeutic strategy. However, further improvements in efficiency are desired for practical application.
Seryoung Kim +3 more
doaj +2 more sources
Facile enzymatic synthesis of base J-containing oligodeoxyribonucleotides and an analysis of the impact of base J on DNA replication in cells. [PDF]
PLoS ONE, 2014 We reported here the use of T4 bacteriophage β-glucosyltransferase (T4 β-GT) for the facile synthesis of base J-containing oligodeoxyribonucleotides (ODNs). We found that the enzyme could catalyze the glucosylation of 5-hydroxymethyl-2-deoxyuridine (5hmU)
Debin Ji, Yinsheng Wang
doaj +2 more sources
Biophysical and biological properties of quadruplex oligodeoxyribonucleotides [PDF]
Nucleic Acids Research, 2003 Single-stranded guanosine-rich oligodeoxyribonucleotides (GROs) have a propensity to form quadruplex structures that are stabilized by G-quartets. In addition to intense speculation about the role of G-quartet formation in vivo, there is considerable interest in the therapeutic potential of quadruplex oligonucleotides as aptamers or non-antisense ...
Virna, Dapić +6 more
openaire +3 more sources
Immobilization of oligodeoxyribonucleotides with multiple anchors to microchips [PDF]
Nucleic Acids Research, 2001 Facile modification of oligodeoxyribonucleotides is required for efficient immobilization to a pre-activated glass surface. This report presents an oligodeoxyribonucleotide which contains a hairpin stem-loop structure with multiple phosphorothioate moieties in the loop.
Satyam Nampalli, Xiaodong Zhao
exaly +3 more sources
Use of a Dihydroxyacetone Derivative as Protecting Reagent to Phosphorylate Oligonucleotides. [PDF]
Curr ProtocAbstract We present here a new reagent enabling the supported synthesis of oligodeoxynucleotides (ODNs) and oligoribonucleotides (ORNs) containing a phosphate group at the 5′‐terminal position after complete deprotection. This reagent, derived from a dihydroxyacetone core, contains a dimethoxytrityl (DMTr) group. The procedure for final deprotection is
Lartia R.
europepmc +2 more sources
THE ENZYMATIC CONDENSATION OF OLIGODEOXYRIBONUCLEOTIDES WITH POLYDEOXYRIBONUCLEOTIDES [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1964 exaly +3 more sources
Molecules, 2023 Raman nanoparticle probes are a potent class of optical labels for the interrogation of pathological and physiological processes in cells, bioassays, and tissues.
Monica-Cornelia Sardaru +4 more
doaj +1 more source