Results 31 to 40 of about 12,307 (190)
Direct Attachment of Conjugate Groups to the 5′ Terminus of Oligodeoxyribonucleotides [PDF]
This unit gives protocols for the attachment of intercalating and photoreactive conjugate groups to oligodeoxyribonucleotides. Protocols are given for acridine‐ and psoralen‐conjugated oligonucleotides, and include attachment of the linker, preparation ...
Asseline, Ulysse +3 more
core +1 more source
Oligodeoxyribonucleotides used in this study.
Oligodeoxyribonucleotides used in this study.
Kazuo Yamagata (128504) +6 more
core +1 more source
Convenient synthesis of arabinonucleoside containing oligodeoxyribonucleotides [PDF]
C2 substituted arabinofuranosyluracil derivatives were synthesized and its incorporations into DNA were easily carried out by using post-synthetic modification.
H, Ozaki +3 more
openaire +2 more sources
High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin.
Yong-Yu Liu +6 more
doaj +1 more source
Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview
This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley +1 more source
Background High-density oligonucleotide arrays are widely used for analysis of genome-wide expression and genetic variation. Affymetrix GeneChips – common high-density oligonucleotide arrays – contain perfect match (PM) and mismatch (MM) probes generated
Kashiwagi Akiko +4 more
doaj +1 more source
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
A Highly Efficient Synthesis of Oligodeoxyribonucleotides Containing the 2‘-Deoxyribonolactone ...
Eric Defrancq (1557424) +3 more
core +1 more source

