Results 51 to 60 of about 4,788 (197)
Cellular Physiology and Biochemistry, 2018 Background/Aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation and apoptosis.
Fang He +8 more
doaj +1 more source
Journal of Nucleic Acids, Volume 2026, Issue 1, 2026.Owing to their enhanced functional properties, 2 ′,4 ′‐bridged nucleic acids/locked nucleic acids (2 ′,4 ′‐BNAs/LNAs) are considered promising candidates for antisense oligonucleotide therapeutics. The spatial arrangement of LNA residues within the oligonucleotide sequence is a key determinant of binding affinity to the target RNA.
Elisa Tomita-Sudo +7 more
wiley +1 more source
Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1 [PDF]
, 2017 Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in tumorigenesis. Ample studies demonstrated the activities of YY1 in regulating gene expression and mediating differential protein modifications.
Akman, Steven A. +12 more
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Sequence-specific cleavage of double helical DNA by triple helix formation [PDF]
, 1987 Homopyrimidine oligodeoxyribonucleotides with EDTA-Fe attached at a single position bind the corresponding homopyrimidine-homopurine tracts within large double-stranded DNA by triple helix formation and cleave at that site.
Dervan, Peter B., Moser, Heinz E.
core +1 more source
Use of a Dihydroxyacetone Derivative as Protecting Reagent to Phosphorylate Oligonucleotides
Current Protocols, Volume 5, Issue 10, October 2025.Abstract We present here a new reagent enabling the supported synthesis of oligodeoxynucleotides (ODNs) and oligoribonucleotides (ORNs) containing a phosphate group at the 5′‐terminal position after complete deprotection. This reagent, derived from a dihydroxyacetone core, contains a dimethoxytrityl (DMTr) group. The procedure for final deprotection is
Rémy Lartia
wiley +1 more source
Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates
Nucleic Acids Research, 1995 An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen is substituted by a 3'-nitrogen, is described. Synthesis of the title compounds was accomplished by the following synthetic steps. First, 5'-O-DMT base-protected-3'-amino-2',3'-dideoxynucleosides were prepared.
J K, Chen +3 more
openaire +3 more sources
A novel approach to the synthesis of oligodeoxyribonucleotide boranophosphates [PDF]
Nucleic Acids Symposium Series, 2000 Deoxyribonucleoside 3'-boranophosphate derivatives including adenine, cytosine, guanine, and thymine bases were synthesized in good yields by the use of a new boranophosphorylation reaction. The reaction was found to be effective for the formation of internucleotidic boranophosphate linkages.
T, Wada, M, Shimizu, N, Oka, K, Saigo
openaire +2 more sources
Plant Biotechnology Journal, Volume 23, Issue 9, Page 3798-3813, September 2025.Summary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Miriam Marín‐Sanz +5 more
wiley +1 more source
Analysis of efficiency of purification of HEX-oligonucleotides obtained by modified deblocking
Тонкие химические технологии, 2012 A new way of deblocking of synthetic hexachlorofluorescein-oligodeoxyribonucleotides (HEX-ODN) prevents the modification of the label and the accumulation of difficult to separated by-product.
A. G. Mosina +4 more
doaj
Reactivity of human and porcine natural interferon-alpha producing cells to immunostimulatory DNA [PDF]
, 2003 The interferon-α (IFN-α) inducing capacity of various forms of immunostimulatory DNA and the identity of the IFN-α producing cells (IPC) were studied in human and porcine leukocytes.
Magnusson, Mattias
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