Results 61 to 70 of about 11,432 (197)

Cas9‐ and Cas12a‐mediated excision and replacement of the celiac disease‐related α‐gliadin immunogenic complex in hexaploid wheat

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3798-3813, September 2025.
Summary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Miriam Marín‐Sanz, Susana Sánchez‐León, María H. Guzmán‐López, Colby G. Starker, Daniel F. Voytas, Francisco Barro   +5 more
wiley   +1 more source

Fast Deprotection of Synthetic Oligodeoxyribonucleotides Using Standard Reagents under Microwave Irradiation

, 2008
Fast methods for the removal of permanent amide exo-cyclic protective groups widely used in phosphoramidite- method DNA synthesis are desirable for many genomics and proteomics applications. In this communication, we present a method for the deprotection
LaFlamme, Mark, Culf, A.S., Cuperlovic-Culf, Miroslava, Ouellette, Rodney J., Tardiff, Bennett J.   +4 more
core   +1 more source

Antiviral activity of modified oligonucleotides in human lymphoid cells infected with a strain of HIV‐1

Юг России: экология, развитие
Aim. To investigate the cell entry and antiretroviral properties of modified oligodeoxyribonucleotides targeting highly conserved regions of the HIV‐1 genome: the study was conducted using modified oligonucleotides containing phosphorothioate ...
L. G. Gotfrid, A. S. Pavlova, M. S. Kupryushkin, I. A. Pyshnaya, N. M. Gashnikova   +4 more
doaj   +1 more source

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, Volume 5, Issue 8, August 2025.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1 [PDF]

, 2020
Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleotides (
Abdu, K., Williams, D.M., Aiertza, M.K., Wilkinson, O.J., Margison, G.P., Senthong, P., Povey, A.C., Craggs, T.D.   +7 more
core   +1 more source

Antibodies elicited by defined oligodeoxyribonucleotide sequences

Nucleic Acids Research, 1978
Antibodies to the oligodeoxyribonucleotides d(pT)3, d(pT)4, d(pT)6 and d(pA-A-T-T) were elicited in rabbits by immunization with electrostatic complexes of the respective haptens with methylated bovine serum albumin (MBSA). The antisera were assayed by complement fixation using denatured DNA's of various sources as antigens.
H J, Störl, H, Simon, H, Barthelmes
openaire   +3 more sources

A novel approach to the synthesis of oligodeoxyribonucleotide boranophosphates [PDF]

Nucleic Acids Symposium Series, 2000
Deoxyribonucleoside 3'-boranophosphate derivatives including adenine, cytosine, guanine, and thymine bases were synthesized in good yields by the use of a new boranophosphorylation reaction. The reaction was found to be effective for the formation of internucleotidic boranophosphate linkages.
T, Wada, M, Shimizu, N, Oka, K, Saigo
openaire   +2 more sources

An engineered redox‐switchable streptavidin mutein enables the high‐affinity capture and efficient elution of biotinylated ligands

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Although the high affinity and specificity of the interaction between streptavidin and biotin are widely utilized to isolate biotinylated ligands, their elution over practical timescales requires the use of strongly denaturing conditions that are incompatible with many target biomolecules.
Jesse M. Marangoni, Adriana Zutic, Amrita Dhindsa, Emmanuella Uche‐Orji, Sui‐Lam Wong, Kenneth K. S. Ng   +5 more
wiley   +1 more source

Characterization of oligodeoxyribonucleotide synthesis on glass plates [PDF]

Nucleic Acids Research, 2001
Achieving high fidelity chemical synthesis on glass plates has become increasingly important, since glass plates are substrates widely used for miniaturized chemical and biochemical reactions and analyses. DNA chips can be directly prepared by synthesizing oligonucleotides on glass plates, but the characterization of these micro-syntheses has been ...
E, LeProust, H, Zhang, P, Yu, X, Zhou, X, Gao   +4 more
openaire   +2 more sources

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, Volume 64, Issue 31, July 28, 2025.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source