Results 61 to 70 of about 4,788 (197)

Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality [PDF]

, 2017
In this paper, we report investigations, based on circular dichroism, nuclear magnetic resonance spectroscopy and electrophoresis methods, on three oligonucleotide sequences, each containing one 3- 3 and two 5-5 inversion of polarity sites, and four
Amato, Teresa, Esposito, Veronica, Galeone, Aldo, Mayol, Luciano, Russo, Annapina, Russo, Giulia, Virgilio, Antonella   +6 more
core   +1 more source

Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides

Nucleic Acids Research, 1983
The paper describes an improved method for the synthesis of oligodeoxyribonucleotides using phosphoramidite chemistry. Our procedure relies on novel phosphoramidite intermediates, the deoxyribonucleoside-3'-morpholine-methoxyphosphins. These compounds are extremely stable and can be purified readily.
T, Dörper, E L, Winnacker
openaire   +3 more sources

Characterization of oligodeoxyribonucleotide synthesis on glass plates [PDF]

Nucleic Acids Research, 2001
Achieving high fidelity chemical synthesis on glass plates has become increasingly important, since glass plates are substrates widely used for miniaturized chemical and biochemical reactions and analyses. DNA chips can be directly prepared by synthesizing oligonucleotides on glass plates, but the characterization of these micro-syntheses has been ...
E, LeProust, H, Zhang, P, Yu, X, Zhou, X, Gao   +4 more
openaire   +2 more sources

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, Volume 5, Issue 8, August 2025.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Identifying the impact of G-quadruplexes on Affymetrix 3' arrays using cloud computing. [PDF]

, 2010
A tetramer quadruplex structure is formed by four parallel strands of DNA/ RNA containing runs of guanine. These quadruplexes are able to form because guanine can Hoogsteen hydrogen bond to other guanines, and a tetrad of guanines can form a stable ...
Harrison, AP, Memon, FN, Owen, AM, Sanchez-Graillet, O, Upton, GJG   +4 more
core   +2 more sources

An engineered redox‐switchable streptavidin mutein enables the high‐affinity capture and efficient elution of biotinylated ligands

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Although the high affinity and specificity of the interaction between streptavidin and biotin are widely utilized to isolate biotinylated ligands, their elution over practical timescales requires the use of strongly denaturing conditions that are incompatible with many target biomolecules.
Jesse M. Marangoni, Adriana Zutic, Amrita Dhindsa, Emmanuella Uche‐Orji, Sui‐Lam Wong, Kenneth K. S. Ng   +5 more
wiley   +1 more source

Antiviral activity of modified oligonucleotides in human lymphoid cells infected with a strain of HIV‐1

Юг России: экология, развитие
Aim. To investigate the cell entry and antiretroviral properties of modified oligodeoxyribonucleotides targeting highly conserved regions of the HIV‐1 genome: the study was conducted using modified oligonucleotides containing phosphorothioate ...
L. G. Gotfrid, A. S. Pavlova, M. S. Kupryushkin, I. A. Pyshnaya, N. M. Gashnikova   +4 more
doaj   +1 more source

Highly efficient 5\u27 capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase [PDF]

, 2018
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription
Basu, Urmimala, Bird, Jeremy G, Ebright, Richard H., Grudzien-Nogalska, Ewa, Kiledjian, Megerditch, Kuster, David, Nickels, Bryce E., Patel, Smita S., Ramachandran, Aparna, Temiakov, Dmitry, Towheed, Atif, Wallace, Douglas C.   +11 more
core   +1 more source

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, Volume 64, Issue 31, July 28, 2025.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells

Scientific Reports
Single-stranded oligodeoxyribonucleotide (ssODN) gene editing has emerged as a promising therapeutic strategy. However, further improvements in efficiency are desired for practical application.
Seryoung Kim, Yosuke Matsushita, Toyomasa Katagiri, Hideaki Maseda   +3 more
doaj   +1 more source