Results 61 to 70 of about 12,307 (190)

Antiviral activity of antisense oligonucleotide combinations targeting various regions of the HIV‐1 genome

Юг России: экология, развитие
The goal of this study was to investigate the effectiveness in suppressing viral replication of combinations of antisense phosphorothioate oligodeoxyribonucleotides targeting conserved regions in the HIV‐1 genome.The antiretroviral activity of the ...
L. G. Gotfrid, M. S. Kupryushkin, A. S. Pavlova, M. P. Gashnikova, A. V. Totmenin, I. A. Pyshnaya, N. M. Gashnikova   +6 more
doaj   +1 more source

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, Volume 64, Issue 31, July 28, 2025.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Chemical Syntheses of Oligodeoxyribonucleotides Containing Spore Photoproduct

, 2013
5-(α-Thyminyl)-5,6-dihydrothymine, also called spore photoproduct or SP, is commonly found in the genomic DNA of UV-irradiated bacterial endospores. Despite the fact that SP was discovered nearly 50 years ago, its biochemical impact is still largely ...
Jian, Yajun, Lei Li, Yajun Jian, Li, Lei
core   +1 more source

Study on Growth Inhibition of Implanted Tumor in Nude Mice by Antisense Oligodeoxynucleotide Targeting Telomerase RNA

Chinese Journal of Lung Cancer, 2008
Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy.
Hongtao YU, Hongjun WANG, Qiong CHEN
doaj  

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

Synthesis and characterization of new 3 '-3 ' linked oligodeoxyribonucleotides for alternate strand triple helix formation

, 1999
Protected forms of 1,2,3-propanetriol and cis, cis-1,3,5- cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3'-3' linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3 ...
MUSUMECI D., MESSERE, Anna, PICCIALLI G., MONTESARCHIO D., DI FABIO G., DE NAPOLI L.   +5 more
core   +2 more sources

The synthesis of oligodeoxyribonucleotides using RNA ligase

Nucleic Acids Research, 1979
T4 RNA ligase catalyzes the addition of a single deoxyribonucleoside 3',5'-bisphosphate to the 3'-hydroxyl of oligodeoxyribonucleotides (Hinton et al. (1978) Biochemistry 17, 5091). We have determined improved conditions for this reaction which give yields equal to or greater than 85% when any of five common deoxyribonucleoside bisphosphate (pdAp, pdCp,
D M, Hinton, R I, Gumport
openaire   +3 more sources

Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model

Animal Genetics, Volume 56, Issue 1, February 2025.
Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee, Bo‐Young Lee, Byeonghwi Lim, Rasel Uzzaman, Goo Jang, Kwan‐Suk Kim   +5 more
wiley   +1 more source

Synthesis of Thymidine Dimers Containing a New Internucleosidic Amide Linkage and their Incorporation into Oligodeoxyribonucleotides

, 1995
The synthesis of thymidine dimers 5a,b containinga chiral carbon in the propionamide internucleosidiclinkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA ...
DE NAPOLI, LORENZO, IADONISI, ALFONSO, MONTESARCHIO, DANIELA, PICCIALLI, GENNARO, VARRA, MICHELA   +4 more
core   +1 more source