Results 81 to 90 of about 4,788 (197)
Chinese Journal of Lung Cancer, 2008 Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy.
Hongtao YU, Hongjun WANG, Qiong CHEN
doaj
Insights into DNA platination within unusual structural settings [PDF]
, 2011 2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie +2 more
core +2 more sources
The synthesis of oligodeoxyribonucleotides using RNA ligase
Nucleic Acids Research, 1979 T4 RNA ligase catalyzes the addition of a single deoxyribonucleoside 3',5'-bisphosphate to the 3'-hydroxyl of oligodeoxyribonucleotides (Hinton et al. (1978) Biochemistry 17, 5091). We have determined improved conditions for this reaction which give yields equal to or greater than 85% when any of five common deoxyribonucleoside bisphosphate (pdAp, pdCp,
D M, Hinton, R I, Gumport
openaire +3 more sources
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga +7 more
wiley +1 more source
Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions [PDF]
, 1989 Sindbis virus mutant ts103 is aberrant in the assembly of virus particles. During virus budding, proper nucleocapsid-glycoprotein interactions fail to occur such that particles containing many nucleocapsids are formed, and the final yield of virus is low.
Hahn, Chang S. +4 more
core
Iterative approach to computational enzyme design [PDF]
, 2012 A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for three chemical reactions through the ...
Blomberg, Rebecca +8 more
core +2 more sources
Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling
ChemBioChem, Volume 25, Issue 19, October 1, 2024.Photoactivatable oligonucleotides in combination with recent developments in mass spectrometry are powerful tools for studying nucleic acid‐protein interactions involved in numerous biological processes. In this review, we provide a comprehensive overview of the different strategies for incorporating the most used photoreactive reagents into ...
Carole Saintomé +3 more
wiley +1 more source
Design of Geometric Molecular Bonds
, 2016 An example of a nonspecific molecular bond is the affinity of any positive charge for any negative charge (like-unlike), or of nonpolar material for itself when in aqueous solution (like-like).
Doty, David, Winslow, Andrew
core +1 more source
Hitting bacteria at the heart of the central dogma: sequence-specific inhibition [PDF]
, 2007 An important objective in developing new drugs is the achievement of high specificity to maximize curing effect and minimize side-effects, and high specificity is an integral part of the antisense approach.
Louise Rasmussen +2 more
core +2 more sources
CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML
Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.Abstract Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in leukaemic cell differentiation are still unknown.
Chunmei Guo +9 more
wiley +1 more source