Results 81 to 90 of about 11,432 (197)

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

Cancer Science, Volume 116, Issue 1, Page 214-225, January 2025.
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small vessels. Recent progress uncovering the genetic characteristics associated with MYD88/CD79B mutations has stimulated interest in the use of drugs targeting B‐cell ...
Mika Takai, Kazuyuki Shimada, Katsuya Furukawa, Yusuke Yamaga, Soichi Yoshiyama, Yusuke Kagaya, Takashi Suzuki, Kazuhiko Hayashi, Satoko Shimada, Kennosuke Karube, Hitoshi Kiyoi   +10 more
wiley   +1 more source

Synthesis of Thymidine Dimers Containing a New Internucleosidic Amide Linkage and their Incorporation into Oligodeoxyribonucleotides

, 1995
The synthesis of thymidine dimers 5a,b containinga chiral carbon in the propionamide internucleosidiclinkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA ...
DE NAPOLI, LORENZO, IADONISI, ALFONSO, MONTESARCHIO, DANIELA, PICCIALLI, GENNARO, VARRA, MICHELA   +4 more
core   +1 more source

Synthesis and purification of oligodeoxyribonucleotides: a modified approach

, 1987
A reduction in monomer consumption in the solid phase synthesis of oligodeoxyribonucleotides has been achieved by introducing a repeat coupling approach.
Kadalayil, Latha P., Brahmachari, S. K., Majumder, Kumud   +2 more
core   +1 more source

Nanostructural Modulation of G‐Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga, Ilaria Piccialli, Francesca Greco, Stefano D'Errico, Maria Grazia Nolli, Nicola Borbone, Giorgia Oliviero, Giovanni N. Roviello   +7 more
wiley   +1 more source

Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling

ChemBioChem, Volume 25, Issue 19, October 1, 2024.
Photoactivatable oligonucleotides in combination with recent developments in mass spectrometry are powerful tools for studying nucleic acid‐protein interactions involved in numerous biological processes. In this review, we provide a comprehensive overview of the different strategies for incorporating the most used photoreactive reagents into ...
Carole Saintomé, Océane Monfret, Gilles Doisneau, Dominique Guianvarc'h   +3 more
wiley   +1 more source

Oxathiaphospholane Approach to the Synthesis of Oligodeoxyribonucleotides Containing Stereodefined Internucleotide Phosphoroselenoate Function^†

, 2016
5‘-O-DMT-deoxyribonucleoside-3‘-O-(2-selena-4,4-pentamethylene-1,3,2-oxathiaphospholane) monomers, derivatives of dA, dC, dG, and T, can be resolved into pure P-diastereomers by silica gel column chromatography.
Wojciech J. Stec (2471143), Anna Maciaszek (2672335), Piotr Guga (259019)   +2 more
core   +1 more source

Nanocomposites consisting of titanium dioxide nanoparticles, antisense oligonucleotides, and photoactive groups as agents for effective action on nucleic acids

Журнал микробиологии, эпидемиологии и иммунобиологии
Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the modification of nucleic acids.
Asya S. Levina, Marina N. Repkova, Oleg Y. Mazurkov, Elena V. Makarevich, Natalya A. Mazurkova, Valentina F. Zarytova   +5 more
doaj   +1 more source

Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides

Nucleic Acids Research, 1988
The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were converted to the 5'-phosphorylated derivates.
S, Spitzer, F, Eckstein
openaire   +3 more sources

CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML

Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.
Abstract Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in leukaemic cell differentiation are still unknown.
Chunmei Guo, Xinxin Lv, Qiuling Zhang, Lina Yi, Yingying Ren, Zhaopeng Li, Jinsong Yan, Shanliang Zheng, Ming‐Zhong Sun, Shuqing Liu   +9 more
wiley   +1 more source

Synthesis of oligodeoxyribonucleotides using in situ prepared nucleoside methyl phosphochloridite intermediates

, 1985
Synthesis of oligodeoxyribonucleotides on silica gel support using 5'-O-dimethoxytrityl-(N-acyl)-deoxyribonucleoside 3'-(O-methyl phosphochloridite) intermediates (I) is described.
Zdeněk Hostomský, Hana Večerková, André Rosenthal, Jiří Smrt, Jitka Forstová   +4 more
core   +1 more source