Results 71 to 80 of about 4,788 (197)

Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A [PDF]

, 2011
DNA-sequence and structure dependence on the formation of minor groove complexes at 5′-XCTAGY-3′ by the short lexitropsin thiazotropsin A are explored based on NMR spectroscopy, isothermal titration calorimetry (ITC), circular dichroism (CD) and ...
Anthony, Anthony, Anthony, Barber, Bergqvist, Blaskó, Borea, Chaires, Chenoweth, Dervan, Dervan, Engel, Freyer, Freyer, Gottesfeld, Haq, Haq, Harris, James, Khalaf, Kwong, Ladbury, Lafont, Marques, Neidle, O'Brien, Pang, Parkinson, Pelton, Pullman, Rodger, Schwabe, Spolar, Suckling, Trauger, Treesuwan, Wemmer, Wemmer, Wittayanarakul   +38 more
core   +2 more sources

Antibodies elicited by defined oligodeoxyribonucleotide sequences

Nucleic Acids Research, 1978
Antibodies to the oligodeoxyribonucleotides d(pT)3, d(pT)4, d(pT)6 and d(pA-A-T-T) were elicited in rabbits by immunization with electrostatic complexes of the respective haptens with methylated bovine serum albumin (MBSA). The antisera were assayed by complement fixation using denatured DNA's of various sources as antigens.
H J, Störl, H, Simon, H, Barthelmes
openaire   +3 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines [PDF]

, 2012
Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated.
Arvai, A.S., Butt, A., Latypov, V.F., Margison, G.P., Marriott, A.S., McGown, G., Millington, C.L., Povey, A.C., Santibanez-Koref, M.F., Senthong, P., Tainer, J.A., Thorncroft, M., Tubbs, J.L., Watson, A.J., Wilkinson, O.J., Williams, D.M.   +15 more
core   +1 more source

Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry [PDF]

, 2020
RATIONALE: Liquid AP-MALDI has been shown to enable the production of ESI-like multiply charged analyte ions with little sample consumption and long-lasting, robust ion yield for sensitive analysis by mass spectrometry. Previous reports have focused on
Brown, Jeffery M., Cramer, Rainer, Hale, Oliver J., Morris, Michael, Ryumin, Pavel   +4 more
core   +1 more source

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes [PDF]

, 2017
A series of oligodeoxyribonucleotides and oligoribonucleotides containing single and multiple tricyclo(tc)-nucleosides in various arrangements were prepared and the thermal and thermodynamic transition profiles of duplexes with complementary DNA and RNA ...
Gerber, Anna-Barbara, Ittig, Damian, Leumann, Christian J.   +2 more
core  

Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model

Animal Genetics, Volume 56, Issue 1, February 2025.
Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee, Bo‐Young Lee, Byeonghwi Lim, Rasel Uzzaman, Goo Jang, Kwan‐Suk Kim   +5 more
wiley   +1 more source

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity [PDF]

, 2018
The biological relevance of tetramolecular G-quadruplexes especially as anti-HIV agents has been extensively reported in the literature over the last years. In the light of our recent results regarding the slow G-quadruplex folding kinetics of ODNs based
Di Fabio, Giovanni, Liekens, Sandra, Noppen, Sam, Pannecouque, Christophe, Romanucci, Valeria, Zarrelli, Armando   +5 more
core   +1 more source

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

Cancer Science, Volume 116, Issue 1, Page 214-225, January 2025.
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small vessels. Recent progress uncovering the genetic characteristics associated with MYD88/CD79B mutations has stimulated interest in the use of drugs targeting B‐cell ...
Mika Takai, Kazuyuki Shimada, Katsuya Furukawa, Yusuke Yamaga, Soichi Yoshiyama, Yusuke Kagaya, Takashi Suzuki, Kazuhiko Hayashi, Satoko Shimada, Kennosuke Karube, Hitoshi Kiyoi   +10 more
wiley   +1 more source