Results 71 to 80 of about 12,307 (190)

Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates

Nucleic Acids Research, 1995
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen is substituted by a 3'-nitrogen, is described. Synthesis of the title compounds was accomplished by the following synthetic steps. First, 5'-O-DMT base-protected-3'-amino-2',3'-dideoxynucleosides were prepared.
J K, Chen, R G, Schultz, D H, Lloyd, S M, Gryaznov   +3 more
openaire   +3 more sources

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

Cancer Science, Volume 116, Issue 1, Page 214-225, January 2025.
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small vessels. Recent progress uncovering the genetic characteristics associated with MYD88/CD79B mutations has stimulated interest in the use of drugs targeting B‐cell ...
Mika Takai, Kazuyuki Shimada, Katsuya Furukawa, Yusuke Yamaga, Soichi Yoshiyama, Yusuke Kagaya, Takashi Suzuki, Kazuhiko Hayashi, Satoko Shimada, Kennosuke Karube, Hitoshi Kiyoi   +10 more
wiley   +1 more source

Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method [PDF]

, 2000
The phosphoramidite approach has had a major impact on the synthesis of oligonucleotides. This unit describes parameters that affect the performance of this method for preparing oligodeoxyribonucleotides, as well as a number of compatible strategies ...
Marvin H. Caruthers, Caruthers, Marvin H., Beaucage, Serge L., Serge L. Beaucage   +3 more
core   +1 more source

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1 [PDF]

, 2020
Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleotides (
Abdu, K., Williams, D.M., Aiertza, M.K., Wilkinson, O.J., Margison, G.P., Senthong, P., Povey, A.C., Craggs, T.D.   +7 more
core   +1 more source

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1

Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleotides (
Abdu, Kabir, Williams, David, Aiertza Otxotorena, Miren Karmele, Craggs, Timothy D., Wilkinson, Oliver J., Povey, Andrew; id_orcid, Senthong, Pattama, Margison, Geoffrey   +7 more
core   +8 more sources

Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides

Nucleic Acids Research, 1983
The paper describes an improved method for the synthesis of oligodeoxyribonucleotides using phosphoramidite chemistry. Our procedure relies on novel phosphoramidite intermediates, the deoxyribonucleoside-3'-morpholine-methoxyphosphins. These compounds are extremely stable and can be purified readily.
T, Dörper, E L, Winnacker
openaire   +3 more sources

Nanostructural Modulation of G‐Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga, Ilaria Piccialli, Francesca Greco, Stefano D'Errico, Maria Grazia Nolli, Nicola Borbone, Giorgia Oliviero, Giovanni N. Roviello   +7 more
wiley   +1 more source

Synthesis of Modified Oligodeoxyribonucleotides on a Solid-Phase Support via Derivatization of a Selectively Revealed 2‘-Amino-2‘-deoxyuridine

, 2016
High yields of oligodeoxyribonucleotides modified at the C2‘-position of site specifically incorporated 2‘-amino-2‘-deoxyuridine are obtained by photolytically unmasking the nucleophile in an otherwise protected solid-phase support-bound ...
Marc M. Greenberg (8794), Jae-Taeg Hwang (2951493)   +1 more
core   +1 more source

Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling

ChemBioChem, Volume 25, Issue 19, October 1, 2024.
Photoactivatable oligonucleotides in combination with recent developments in mass spectrometry are powerful tools for studying nucleic acid‐protein interactions involved in numerous biological processes. In this review, we provide a comprehensive overview of the different strategies for incorporating the most used photoreactive reagents into ...
Carole Saintomé, Océane Monfret, Gilles Doisneau, Dominique Guianvarc'h   +3 more
wiley   +1 more source

Oxathiaphospholane Approach to the Synthesis of Oligodeoxyribonucleotides Containing Stereodefined Internucleotide Phosphoroselenoate Function^†

, 2016
5‘-O-DMT-deoxyribonucleoside-3‘-O-(2-selena-4,4-pentamethylene-1,3,2-oxathiaphospholane) monomers, derivatives of dA, dC, dG, and T, can be resolved into pure P-diastereomers by silica gel column chromatography.
Wojciech J. Stec (2471143), Anna Maciaszek (2672335), Piotr Guga (259019)   +2 more
core   +1 more source