Results 71 to 80 of about 11,432 (197)
Chemical Syntheses of Oligodeoxyribonucleotides Containing Spore Photoproduct
, 2016 5-(α-Thyminyl)-5,6-dihydrothymine, also called spore photoproduct or SP, is commonly found in the genomic DNA of UV-irradiated bacterial endospores. Despite the fact that SP was discovered nearly 50 years ago, its biochemical impact is still largely ...
Yajun Jian (1321638), Lei Li (29537)
core +1 more source
, 1999 Protected forms of 1,2,3-propanetriol and cis, cis-1,3,5- cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3'-3' linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3 ...
MUSUMECI D. +5 more
core +2 more sources
Advanced Science, Volume 12, Issue 28, July 24, 2025.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
Chemical Syntheses of Oligodeoxyribonucleotides Containing Spore Photoproduct
, 2013 5-(α-Thyminyl)-5,6-dihydrothymine, also called spore photoproduct or SP, is commonly found in the genomic DNA of UV-irradiated bacterial endospores. Despite the fact that SP was discovered nearly 50 years ago, its biochemical impact is still largely ...
Jian, Yajun, Lei Li, Yajun Jian, Li, Lei
core +1 more source
Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives
Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao +8 more
wiley +1 more source
Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method [PDF]
, 2000 The phosphoramidite approach has had a major impact on the synthesis of oligonucleotides. This unit describes parameters that affect the performance of this method for preparing oligodeoxyribonucleotides, as well as a number of compatible strategies ...
Marvin H. Caruthers +3 more
core +1 more source
Chinese Journal of Lung Cancer, 2008 Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy.
Hongtao YU, Hongjun WANG, Qiong CHEN
doaj
The synthesis of oligodeoxyribonucleotides using RNA ligase
Nucleic Acids Research, 1979 T4 RNA ligase catalyzes the addition of a single deoxyribonucleoside 3',5'-bisphosphate to the 3'-hydroxyl of oligodeoxyribonucleotides (Hinton et al. (1978) Biochemistry 17, 5091). We have determined improved conditions for this reaction which give yields equal to or greater than 85% when any of five common deoxyribonucleoside bisphosphate (pdAp, pdCp,
D M, Hinton, R I, Gumport
openaire +3 more sources
Animal Genetics, Volume 56, Issue 1, February 2025.Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee +5 more
wiley +1 more source
, 2016 High yields of oligodeoxyribonucleotides modified at the C2‘-position of site specifically incorporated 2‘-amino-2‘-deoxyuridine are obtained by photolytically unmasking the nucleophile in an otherwise protected solid-phase support-bound ...
Marc M. Greenberg (8794) +1 more
core +1 more source