Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1 [PDF]
, 2017 Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in tumorigenesis. Ample studies demonstrated the activities of YY1 in regulating gene expression and mediating differential protein modifications.
Akman, Steven A. +12 more
core
Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy
Advanced Science, Volume 11, Issue 1, January 5, 2024.Deregulated Inflammation is one of the most common diseases in human health, and its management remains a significant challenge. Notably, stimulus‐responsive hydrogels have great potential to break through the predicament faced by severe inflammations treatment.
Haoyu Yu +5 more
wiley +1 more source
Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality [PDF]
, 2017 In this paper, we report investigations, based on circular dichroism, nuclear magnetic resonance spectroscopy and electrophoresis methods, on three oligonucleotide sequences, each containing one 3- 3 and two 5-5 inversion of polarity sites, and four
Amato, Teresa +6 more
core +1 more source
Antibodies elicited by defined oligodeoxyribonucleotide sequences
Nucleic Acids Research, 1978 Antibodies to the oligodeoxyribonucleotides d(pT)3, d(pT)4, d(pT)6 and d(pA-A-T-T) were elicited in rabbits by immunization with electrostatic complexes of the respective haptens with methylated bovine serum albumin (MBSA). The antisera were assayed by complement fixation using denatured DNA's of various sources as antigens.
Störl Hj, Simon H, H. Barthelmes
openaire +4 more sources
Characteristics of Oligonucleotide Uptake in Human Keratinocyte Cultures [PDF]
, 1993 Oligodeoxyribonucleotides have the potential to interfere selectivity with cellular protein synthesis by sequence-specific hybridization to DNA or RNA molecules.
Garovoy, Marvin R +2 more
core +1 more source
The synthesis of oligodeoxyribonucleotides using RNA ligase
Nucleic Acids Research, 1979 T4 RNA ligase catalyzes the addition of a single deoxyribonucleoside 3',5'-bisphosphate to the 3'-hydroxyl of oligodeoxyribonucleotides (Hinton et al. (1978) Biochemistry 17, 5091). We have determined improved conditions for this reaction which give yields equal to or greater than 85% when any of five common deoxyribonucleoside bisphosphate (pdAp, pdCp,
Richard I. Gumport, Deborah M. Hinton
openaire +4 more sources
Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides [PDF]
Nucleic Acids Research, 2003 Phosphorus-modified phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides were chemically synthesized and their biochemical properties evaluated. Under physiological pH, these DNA analogs possess negative charge and form stable, complementary A-like DNA:RNA heteroduplexes when analyzed via circular dichroism spectroscopy. Phosphonoacetate
David M Sheehan +5 more
openaire +3 more sources
Chinese Journal of Lung Cancer, 2008 Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy.
Hongtao YU, Hongjun WANG, Qiong CHEN
doaj
Sequence-specific cleavage of RNA by a hybrid ribonuclease H [PDF]
, 1994 Site-specific cleavage of the 22-, 132- and 534-base RNAs by the DNA/protein hybrid R Nase H were examined. The 22-base RNA was chemically synthesized, and 132- and 534-base RNAs were prepared by run-off transcription.
Inoue, Hideo +5 more
core +1 more source
A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]
, 2000 The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge +5 more
core +1 more source