Syntheses and characterizations of the in vivo replicative bypass and mutagenic properties of the minor-groove O2-alkylthymidine lesions. [PDF]
, 2014 Endogenous metabolism, environmental exposure, and treatment with some chemotherapeutic agents can all give rise to DNA alkylation, which can occur on the phosphate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of ...
Cai, Qian +3 more
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Журнал микробиологии, эпидемиологии и иммунобиологииRelevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the modification of nucleic acids.
Asya S. Levina +5 more
doaj +1 more source
Reactivity of human and porcine natural interferon-alpha producing cells to immunostimulatory DNA [PDF]
, 2003 The interferon-α (IFN-α) inducing capacity of various forms of immunostimulatory DNA and the identity of the IFN-α producing cells (IPC) were studied in human and porcine leukocytes.
Magnusson, Mattias
core
Identification of Defined Sequences in Domain V of E.coli 23S rRNA in the 50S Subunit Accessible for Hybridization with Complementary Oligodeoxyribonucleotides [PDF]
, 1988 The accessibility of specific sequences in domain V of E. coli 23s rRNA in the 50S subunit to complementary oligodeoxyribonucleotides (cDNA) has been investigated.
Hill, Walter E., Marconi, Richard T.
core +3 more sources
Effective DNA Inhibitors of Cathepsin G by In Vitro Selection [PDF]
, 2008 Cathepsin G (CatG) is a chymotrypsin-like protease released upon degranulation of neutrophils. In several inflammatory and ischaemic diseases the impaired balance between CatG and its physiological inhibitors leads to tissue destruction and platelet ...
Allen +49 more
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Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates
Nucleic Acids Research, 1995 An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen is substituted by a 3'-nitrogen, is described. Synthesis of the title compounds was accomplished by the following synthetic steps. First, 5'-O-DMT base-protected-3'-amino-2',3'-dideoxynucleosides were prepared.
David Lloyd +3 more
openaire +4 more sources
Highly efficient 5\u27 capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase [PDF]
, 2018 Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription
Basu, Urmimala +11 more
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Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles [PDF]
, 2010 The stability, activity, and solubility of a protein sequence are determined by a delicate balance of molecular interactions in a variety of conformational states.
A. Nisthal +41 more
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Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes [PDF]
, 2017 A series of oligodeoxyribonucleotides and oligoribonucleotides containing single and multiple tricyclo(tc)-nucleosides in various arrangements were prepared and the thermal and thermodynamic transition profiles of duplexes with complementary DNA and RNA ...
Gerber, Anna-Barbara +2 more
core
An Unusual Mode of DNA Duplex Association: Watson-Crick Interaction of All-Purine Deoxyribonucleic Acids [PDF]
, 2007 SummaryNucleic acid duplexes associating through purine-purine base pairing have been constructed and characterized in a remarkable demonstration of nucleic acids with mixed sequence and a natural backbone in an alternative duplex structure.
Albalos, Maria +2 more
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