Results 31 to 40 of about 125,904 (241)

Detection of Amyloid-β(1–42) Aggregation With a Nanostructured Electrochemical Sandwich Immunoassay Biosensor

Frontiers in Bioengineering and Biotechnology, 2022
Amyloid-β(1–42) [Aβ(1–42)] oligomer accumulations are associated with physiologic alterations in the brains of individuals with Alzheimer’s disease. In this study, we demonstrate that a nanostructured gold electrode with deposited gold nanoparticles ...
Bing-Yu Wang, Bien-Chen Gu, Gou-Jen Wang, Gou-Jen Wang, Yuan-Han Yang, Yuan-Han Yang, Yuan-Han Yang, Chia-Che Wu, Chia-Che Wu, Chia-Che Wu   +9 more
doaj   +1 more source

High-Temperature Polymer Components Reimagined: Scalable Syntheses and de novo Routes to Structurally Versatile Precursors

Журнал органічної та фармацевтичної хімії
Developing efficient and scalable synthetic protocols for key polymer precursors is crucial to advancing high-performance materials designed to withstand severe thermal environments.
Roman M. Kurganov, Oleh V. Svaliavyn, Yevgen O. Pashchenko, Denis O. Savchenko, Alexander B. Rozhenko, Serhiy V. Ryabukhin, Dmitriy M. Volochnyuk   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

ADMET and DMPK, 2016
This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH.
Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Polycarbonate/Titania Hybrid Films with Localized Photo-Induced Magnetic-Phase Transition

Nanomaterials, 2020
Materials that exhibit the photo-induced magnetic-phase transition of titania are receiving significant attention because they can be easily switched between diamagnetism and paramagnetism by UV irradiation.
Shuta Hara, Sei Kurebayashi, Genza Sanae, Shota Watanabe, Takehiro Kaneko, Takeshi Toyama, Shigeru Shimizu, Hiroki Ikake   +7 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Study on Migrants and Formation Mechanism of Polyglycolic Acid Oligomers in Three Distinct Application Scenarios

Zhipu Xuebao
Poly (glycolic acid) (PGA) is an environmentally friendly, biodegradable polymer commonly utilized in biomedical applications. Due to its high thermal deformation temperature, favorable mechanical properties, and effective gas barrier capabilities, PGA ...
Sheng-feng LIU, Jin-xin LIANG, Tian YIN, Sheng CHEN, Yi-pin DUAN, Ben DONG, Dan LI, Huai-ning ZHONG   +7 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source