Results 221 to 230 of about 20,124 (257)
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Bioorganic & Medicinal Chemistry Letters, 2007
Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
Irmina, Diala +7 more
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Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
Irmina, Diala +7 more
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Native chemical ligation in the synthesis of internally modified oligonucleotide–peptide conjugates
Peptide Science, 2010AbstractPeptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such applications, the site of conjugation is of little importance,
Franziska, Diezmann +2 more
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Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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RNA-Cleaving Oligonucleotide-Peptide Conjugates
2004The most widely described artificial ribonucleases are designed on the basis of RNA-binding domains and low molecular weight constructs bearing functional groups of amino acid residues from catalytic centers of natural RNases: conjugates containing imidazole and carboxylate ions, guanidinium groups (see review Silnikov and Vlassov 200l).
N. L. Mironova +2 more
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ChemInform Abstract: Facile Preparation of 3′‐Oligonucleotide‐Peptide Conjugates.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C. D. JUBY +2 more
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Synthesis of oligonucleotide–peptide conjugates using hydrazone chemical ligation
Tetrahedron Letters, 2002Oligonucleotides constitute a class of potential therapeutic agents. Improvement of certain properties, such as cell-specific delivery, cellular uptake efficiency, intracellular distribution, and target specificity can be accomplished by covalent association to peptides [1], Rather than forming ionic oligonucleotide-peptide complexes, covalent ...
Nathalie Ollivier +5 more
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Synthesis of Oligonucleotide—Peptide Conjugates and Nucleopeptides
ChemInform, 2001AbstractFor Abstract see ChemInform Abstract in Full Text.
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Synthesis of oligonucleotide-peptide conjugates containing a KDEL signal sequence
Tetrahedron Letters, 1993Abstract An improved method of preparation of oligonucleotide-peptide conjugates is described. An oligopeptide containing α and e-aminogroups is mainly substituted at its α-NH 2 end by e-maleimidocaproic acid- N -hydroxysuccinimide ester at pH 6.5 for 1 h. The N α -maleimidocaproyl-peptide derivative, purified by HPLC, reacts with the thiol group of
Khalil Arar +2 more
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Nucleosides, Nucleotides and Nucleic Acids, 2004
To improve antisense oligonucleotide penetration inside cells, conjugates of oligonucleotides and cell-penetrating peptides, covalently linked through a phosphoramide bond, were prepared by a fragment coupling approach in the liquid phase. Two methods were used for this synthesis, i.e., phosphorylation of a peptide amino group by an oligonucleotide ...
Natalia V Sumbatyan +2 more
exaly +3 more sources
To improve antisense oligonucleotide penetration inside cells, conjugates of oligonucleotides and cell-penetrating peptides, covalently linked through a phosphoramide bond, were prepared by a fragment coupling approach in the liquid phase. Two methods were used for this synthesis, i.e., phosphorylation of a peptide amino group by an oligonucleotide ...
Natalia V Sumbatyan +2 more
exaly +3 more sources