Results 231 to 240 of about 20,124 (257)

Synthesis of Oligonucleotide‐Peptide PEG‐Conjugated: The EGG (Oligonucleotide)‐Chicken (Peptide) Dilemma?

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Gian Maria Bonora, Maurizio Ballico, Pietro Campaner, Sara Drioli, Ilaria Adamo   +4 more
openaire   +1 more source

Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide–peptide conjugation

Chemical Communications, 2020
A novel nucleobase-involved native chemical ligation (NbCL) that allows a site–specific oligonucleotide–peptide conjugation via a new S–N acyl transfer reaction between an oxanine nucleobase and N-terminal cysteine.
Eui Kyoung Jang, Yohei Koike, Yuko Ide, Kunihiko Tajima, Kenji Kanaori, Seung Pil Pack   +5 more
openaire   +2 more sources

Targeted Delivery of Oligonucleotide–Peptide Conjugates for Enhanced Kidney-Specific Therapy

Journal of Medicinal Chemistry
Targeted drug delivery has emerged as a crucial strategy to enhance efficacy and minimize side effects from off-target interactions, a particularly relevant approach for kidney diseases, where many treatments suffer from poor targeting efficiency.
Morgane Mannes, Dora Mugoli Chigoho, Charlotte Martin, Thomas Barlow, Tine Hectors, Tom Govaerts, Pieterjan Kayaert, Kirsten De Ridder, Carole Delachaume, Béatrice Vayssière, Martin Andrews, Sophie Hernot, Steven Ballet   +12 more
openaire   +2 more sources

Characterization of antisense oligonucleotide–peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2003
Covalent post-synthesis or solid-phase conjugation of peptides to oligonucleotides has been reported as a possible method of delivering antisense oligonucleotides into cells. While synthesis strategies for preparing these conjugates have been widely addressed, few detailed reports on their structural characterization have been published.
Unni, Tengvall, Seppo, Auriola, Maxim, Antopolsky, Alex, Azhayev, Leo, Biegelman   +4 more
openaire   +2 more sources

Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition

Journal of the American Chemical Society, 2006
Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conjugated to a cationic peptide in order to obtain a diblock compound with an overall positive charge with ...
Fraley, A.W., Pons, B., Dalkara, D., Nullans, G., Behr, J.-P., Zuber, G.   +5 more
openaire   +3 more sources

ds‐Oligonucleotide–Peptide Conjugates Featuring Peptides from the Leucine‐Zipper Region of Fos as Switchable Receptors for the Oncoprotein Jun

ChemBioChem, 2007
(Chemical Equation Presented) Synthetic ds-oligonucleotide-peptide conjugates in which the peptide features the leucine-zipper region of c-Fos are high-affinity and specific receptors for the oncoprotein Jun. The recognition strategy allows the Jun-trapping capability of the constructs to be switched by using appropriately designed ssDNAs. © 2007 Wiley-
Cecilia, Portela, Fernando, Albericio, Ramón, Eritja, Luis, Castedo, José L, Mascareñas   +4 more
openaire   +2 more sources

Synthesis of Oligodeoxynucleotides Containing N⁴-Mercaptoethylcytosine and Their Use in the Preparation of Oligonucleotide−Peptide Conjugates Carrying c-myc Tag-Sequence

Bioconjugate Chemistry, 1998
The preparation and properties of oligodeoxynucleotides containing mercaptoethyl groups at position N-4 of cytosine are described. The resulting thiol-oligodeoxynucleotides were reacted with a maleimido-peptide carrying the c-myc tag-sequence. The peptide-oligonucleotide conjugate is specifically recognized by an anti c-myc monoclonal antibody, thus ...
D, Gottschling, H, Seliger, G, Tarrasón, J, Piulats, R, Eritja   +4 more
openaire   +2 more sources

A Novel Synthesis of Oligonucleotide–Peptide Conjugates with a Base-Labile Phosphate Linker between the Two Components According to the Allyl-Protected Phosphoramidite Strategy

Tetrahedron, 2000
Abstract An efficient synthesis of base-labile nucleotide–peptide conjugates has been accomplished, in which the two components are directly linked between the terminal hydroxyl of a nucleotide and the hydroxyl of a serine or threonine residue of a peptide by a phosphodiester bond. This synthesis utilizes the phosphoramidite method with allyl for the
Akira Sakakura, Yoshihiro Hayakawa
openaire   +1 more source

ChemInform Abstract: A Novel Synthesis of Oligonucleotide—Peptide Conjugates with a Base‐Labile Phosphate Linker Between the Two Components According to the Allyl‐Protected Phosphoramidite Strategy.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Akira Sakakura, Yoshihiro Hayakawa
openaire   +1 more source

Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

Biochemical Engineering Journal, 2021
Kedong Han, Yujing Li, Qingbo Xu
exaly