Results 211 to 220 of about 651,747 (238)

ChemInform Abstract: Facile Preparation of 3′‐Oligonucleotide‐Peptide Conjugates.

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C. D. JUBY, C. D. RICHARDSON, R. BROUSSEAU   +2 more
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Synthesis of oligonucleotide-peptide conjugates containing a KDEL signal sequence

Tetrahedron Letters, 1993
Abstract An improved method of preparation of oligonucleotide-peptide conjugates is described. An oligopeptide containing α and e-aminogroups is mainly substituted at its α-NH 2 end by e-maleimidocaproic acid- N -hydroxysuccinimide ester at pH 6.5 for 1 h. The N α -maleimidocaproyl-peptide derivative, purified by HPLC, reacts with the thiol group of
Khalil Arar, Michel Monsigny, Roger Mayer   +2 more
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ChemInform Abstract: Synthesis of Oligonucleotide‐Peptide Conjugates for Biomedical and Technological Applications

ChemInform, 2013
AbstractReview: 19 refs.
Anna Avino, Santiago Grijalvo, Sonia Perez‐Rentero, Alejandra Garibotti, Montserrat Terrazas, Ramon Eritja   +5 more
openaire   +1 more source

Synthesis of Oligonucleotide‐Peptide PEG‐Conjugated: The EGG (Oligonucleotide)‐Chicken (Peptide) Dilemma?

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Gian Maria Bonora, Maurizio Ballico, Pietro Campaner, Sara Drioli, Ilaria Adamo   +4 more
openaire   +1 more source

Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N -terminal cysteine for oligonucleotide–peptide conjugation

Chemical Communications, 2020
A novel nucleobase-involved native chemical ligation (NbCL) that allows a site–specific oligonucleotide–peptide conjugation via a new S – N acyl transfer reaction between an oxanine nucleobase and
Eui Kyoung Jang, Yohei Koike, Yuko Ide, Kunihiko Tajima, Kenji Kanaori, Seung Pil Pack   +5 more
openaire   +2 more sources

Characterization of antisense oligonucleotide–peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2003
Covalent post-synthesis or solid-phase conjugation of peptides to oligonucleotides has been reported as a possible method of delivering antisense oligonucleotides into cells. While synthesis strategies for preparing these conjugates have been widely addressed, few detailed reports on their structural characterization have been published.
Unni, Tengvall, Seppo, Auriola, Maxim, Antopolsky, Alex, Azhayev, Leo, Biegelman   +4 more
openaire   +2 more sources

Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition

Journal of the American Chemical Society, 2006
Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conjugated to a cationic peptide in order to obtain a diblock compound with an overall positive charge with ...
Fraley, Andrew, Pons, Bénédicte, Dalkara, Deniz, Nullans, Gérard, Behr, Jean-Paul, Zuber, Guy   +5 more
openaire   +3 more sources

ds‐Oligonucleotide–Peptide Conjugates Featuring Peptides from the Leucine‐Zipper Region of Fos as Switchable Receptors for the Oncoprotein Jun

ChemBioChem, 2007
(Chemical Equation Presented) Synthetic ds-oligonucleotide-peptide conjugates in which the peptide features the leucine-zipper region of c-Fos are high-affinity and specific receptors for the oncoprotein Jun. The recognition strategy allows the Jun-trapping capability of the constructs to be switched by using appropriately designed ssDNAs. © 2007 Wiley-
Cecilia, Portela, Fernando, Albericio, Ramón, Eritja, Luis, Castedo, José L, Mascareñas   +4 more
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2'OMe Modification of Anti-miRNA-21 Oligonucleotide–Peptide Conjugate Improves Its Hybridization Properties and Catalytic Activity

Russian Journal of Bioorganic Chemistry, 2019
Abstract: Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis. miRNases integrate in their structure an addressing oligonucleotide, which provides specific binding with miRNA target, and a catalytic group ...
Miroshnichenko, S. K., Amirloo, B., Bichenkova, E. V.; id_orcid 0000-0002-8186-9757, Vlassov, V. V., Zenkova, M. A., Patutina, O. A.   +5 more
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Synthesis of Oligodeoxynucleotides Containing N⁴-Mercaptoethylcytosine and Their Use in the Preparation of Oligonucleotide−Peptide Conjugates Carrying c-myc Tag-Sequence

Bioconjugate Chemistry, 1998
The preparation and properties of oligodeoxynucleotides containing mercaptoethyl groups at position N-4 of cytosine are described. The resulting thiol-oligodeoxynucleotides were reacted with a maleimido-peptide carrying the c-myc tag-sequence. The peptide-oligonucleotide conjugate is specifically recognized by an anti c-myc monoclonal antibody, thus ...
D, Gottschling, H, Seliger, G, Tarrasón, J, Piulats, R, Eritja   +4 more
openaire   +2 more sources