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Oligonucleotide-peptide conjugates as potential antisense agents [PDF]
FEBS Letters, 1999 Oligonucleotide‐peptide conjugates have several applications, including their potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling of pre‐synthesized peptides to the 2′‐position of a ...
Elena A Romanova +2 more
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Nucleosides, Nucleotides and Nucleic Acids, 2003
The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide sequence.
Gian Maria Bonora +2 more
exaly +4 more sources
The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide sequence.
Gian Maria Bonora +2 more
exaly +4 more sources
Preparation of oligonucleotide-peptide conjugates
Bioconjugate Chemistry, 1991A procedure for preparing oligonucleotide-peptide conjugates is presented. It is based on appending a maleimide group to the oligonucleotide for selective coupling to the thiol side chain of a cysteine residue in the peptide. A convenient chromatographic purification procedure, based on Fmoc-on/Fmoc-off, is described.
C H, Tung, M J, Rudolph, S, Stein
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Bioconjugate Chemistry, 2002
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis.
Kwok-Pui Fung, Li-He Zhang
exaly +3 more sources
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis.
Kwok-Pui Fung, Li-He Zhang
exaly +3 more sources
EFFICIENT SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE CONJUGATES ON LARGE SCALE
Nucleosides, Nucleotides and Nucleic Acids, 2001The conjugation of oligonucleotide phosphorothioates with antennapedia peptide was studied in detail to allow efficient preparation of the conjugates on up to 15 mumol scale. Under optimized conditions, the use of oligonucleotides and the peptide in an equimolecular ratio gave the desired conjugates in more than 60% isolated yield.
S O, Doronina, A P, Guzaev, M, Manoharan
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Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates
Nucleosides and Nucleotides, 1999Abstract A small library of oligonucleotide-peptide conjugates has been prepared and studied to explore the influence of the various peptide side chain (cationic, anionic or hydrophobic) on the hybridation properties of the DNA.
C. Frier +2 more
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Facile preparation of 3′oligonucleotide-peptide conjugates
Tetrahedron Letters, 1991Abstract The solid phase synthesis of 3′ deoxyoligonucleotide (17 mer)-peptide conjugates is described. The oligonucleotide is complementary to the template strand of the measles virus in the region of the nucleocapsid protein on the 60 nucleotide leader RNA.
Carl D. Juby +2 more
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Sequence-specific RNA cleavage by oligonucleotide-peptide conjugates
Russian Chemical Bulletin, 2002This paper considers the site-directed cleavage of the in vitro transcript of human tRNALys3 by the conjugate CNH2Gly(ArgLeu)3ArgLeuN—p-DAG—5"CCCTGGACCCTCAGAT3" (conjugate pep-1A) of the oligodeoxyribonucleotide 1A (CCCTGGACCCTCAGAT) with a peptide [LeuArg]4Gly attached at the 5" terminus of the oligonucleotide through diethylene glycol as a linker ...
N. L. Mironova +6 more
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