Results 191 to 200 of about 651,747 (238)
ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2. [PDF]
Mol BiomedWang Y +9 more
europepmc +1 more source
Highly efficient expression of DNA-peptide conjugates in growth-arrested cells. [PDF]
Nat CommunMohamedshah ZY +4 more
europepmc +1 more source
Peptide-phosphorodiamidate morpholino oligomer therapy for dysferlinopathy induces pseudoexon skipping and restoration of functional protein. [PDF]
JCI InsightGooding JE +5 more
europepmc +1 more source
DNA-Peptide Crosslinks Placed at Codon 249 of the p53 Tumor Suppressor Gene Induce G to A Transitions in Human Cells. [PDF]
ChembiochemYawson P +4 more
europepmc +1 more source
Nucleosides, Nucleotides and Nucleic Acids, 2003 The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide sequence.
Maurizio Ballico +2 more
exaly +5 more sources
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Bioconjugate Chemistry, 2002
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis.
Li-He Zhang +2 more
exaly +3 more sources
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis.
Li-He Zhang +2 more
exaly +3 more sources
Nucleosides, Nucleotides and Nucleic Acids, 2004
To improve antisense oligonucleotide penetration inside cells, conjugates of oligonucleotides and cell-penetrating peptides, covalently linked through a phosphoramide bond, were prepared by a fragment coupling approach in the liquid phase. Two methods were used for this synthesis, i.e., phosphorylation of a peptide amino group by an oligonucleotide ...
Natalia Sumbatyan +2 more
exaly +3 more sources
To improve antisense oligonucleotide penetration inside cells, conjugates of oligonucleotides and cell-penetrating peptides, covalently linked through a phosphoramide bond, were prepared by a fragment coupling approach in the liquid phase. Two methods were used for this synthesis, i.e., phosphorylation of a peptide amino group by an oligonucleotide ...
Natalia Sumbatyan +2 more
exaly +3 more sources
Targeted Delivery of a Splice-Switching Oligonucleotide by Cationic Polyplexes of RGD-Oligonucleotide Conjugate [PDF]
Molecular Pharmaceutics, 2012 Nanoparticle-based delivery has become an important strategy to advance therapeutic oligonucleotides into clinical reality. Delivery by nanocarriers can enhance access of oligonucleotides to their pharmacological targets within cells; preferably ...
Xin Ming
exaly +2 more sources
Preparation of oligonucleotide-peptide conjugates
Bioconjugate Chemistry, 1991A procedure for preparing oligonucleotide-peptide conjugates is presented. It is based on appending a maleimide group to the oligonucleotide for selective coupling to the thiol side chain of a cysteine residue in the peptide. A convenient chromatographic purification procedure, based on Fmoc-on/Fmoc-off, is described.
C H, Tung, M J, Rudolph, S, Stein
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