Results 191 to 200 of about 20,124 (257)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Visible Light Induced Mukaiyama Reagent Promoted Desulfurative Modification of Peptides and Proteins with Nucleotides. [PDF]

ACS Cent Sci
Wang M, Lei Y, Song X, Wang C, Guo Q, Zhou X, Mao W, Chen K, Xu Z.   +8 more
europepmc   +1 more source

Engineering Stealth Properties of Fluorescent Polymeric Nanoparticles by Short‐Chain Polysarcosine

Aggregate, Volume 7, Issue 6, June 2026.
To define the minimal polysarcosine chain length required for nanoparticle stealth properties, we engineered dye‐loaded polymeric nanoparticles functionalized with 5‐, 11‐, or 19‐mer peptoids. Only nanoparticles with 19‐mer polysarcosine achieved near‐neutral zeta potential, suppressed nonspecific interactions with glass surface and live cells ...
Tanushree Gupta, Quynh Anh Bui, Horgan Manirakiza, Lina El Hajji, Remi Pelletier, Nicolas Humbert, Abdel Wahab Mouhamad, Andreas Reisch, Arnaud Gautier, Andrey S. Klymchenko   +9 more
wiley   +1 more source

hnRNPUL1 has a dead polynucleotide kinase domain that regulates RNA and protein interactions. [PDF]

iScience
Apostol CV, Li A, Daniels P, Griffith L, Cooper-Knock J, Aguilar-Martinez E, Yonchev ID, Whelan AGR, Shaw PJ, Sudbery IM, Wilson SA.   +10 more
europepmc   +1 more source

Defensin‐DNA Supramolecular Complexes as a New pH‐Sensing Nanomaterial

Aggregate, Volume 7, Issue 6, June 2026.
Crocodylus porosus β‐defensin 13 (CpoBD13), a host defence peptide from the saltwater crocodile, is discovered to interact with single‐ and double‐stranded DNA to form supramolecular assemblies, termed defensin‐induced spherical complexes (DISCs).
Scott A. Williams, Serenay B. Demir, Dilara C. Ozkocak, Michael A. Harris, Ira Ghosh, Matthew J. A. Hein, Stephanie F. Rutter, Gavan J. Francis, Christine J. Hawkins, Ivan K. H. Poon, Thanh Kha Phan, Nicholas P. Reynolds, Adam Mechler, Kazuhide S. Okuda, Marc Kvansakul, Mark D. Hulett   +15 more
wiley   +1 more source

Peptide Nucleic Acids (PNAs) in Antimicrobial Therapy: A Next Generation Strategy. [PDF]

Int J Mol Sci
D'Aniello A, Masi A, Avitabile C, Del Monaco G, Saviano M, Moccia M.   +5 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates. [PDF]

RSC Adv
Balachandran AA, Poudel BH, Rahimizadeh K, Chikkanna A, Veedu RN.   +4 more
europepmc   +1 more source

The hsa_circ_0070354/miR‐4322/RAB3B Axis Facilitates the Carcinogenesis and Development of Non‐Small Cell Lung Cancer (NSCLC)

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Circular RNA (hsa_circ_0070354), also known as circPTPN13, was demonstrated in our previous study that it can be used as a biomarker for diagnosing non‐small cell lung cancer (NSCLC). However, the mechanism of its role in the occurrence and development of NSCLC has not been investigated.
Yuejiao Huang, Shiyi Qin, Yu Zhang, Xinliang Gu, Ming Zheng, Guojie Ling, Lei Yang, Shaoqing Ju   +7 more
wiley   +1 more source

CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages. [PDF]

Mol Pharm
Musil D, Krhutová M, Blažková K, Kramná A, Brázdová A, Výmolová B, Houdová Megová M, Hadzima M, Kryštůfek R, Šubr V, Kostka L, Etrych T, Ormsby T, Šácha P, Abramson J, Konvalinka J.   +15 more
europepmc   +1 more source