Results 171 to 180 of about 20,124 (257)

Soybean‐Derived Exosome‐Like Nanovesicles Regulate Lipid Metabolism via Mitochondrial Biogenesis and UCP1/PGC‐1α Mediated Thermogenesis

Food Frontiers, Volume 7, Issue 4, July 2026.
Soybean‐derived exosome‐like nanovesicles suppress lipid accumulation of adipocytes via UCP1/PGC‐1α mediated thermogenesis pathway and boosting mitochondrial function. ABSTRACT Obesity has become an important public health concern in modern society. Plant‐derived exosome‐like nanovesicles are emerging as candidates for obesity intervention.
Zhenzhu Zhu, Luyuan Ni, Mingwei Gao, Qian Yang, Changli Zhang, Qin Liu   +5 more
wiley   +1 more source

Comparative Evaluation of Antibody-Oligonucleotide Conjugation Strategies for Multiplexed Imaging Applications. [PDF]

Lab Invest
Caraccio C, van de Klashorst J, Cherkas S, Ancel S, Kempchen TN, Vazquez G, Goltsev Y, Wang YX, Nolan GP, Hickey JW.   +9 more
europepmc   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic Frontiers. [PDF]

Pharmaceutics
Xu L, Zhang H, Jiang B, Jiang Y, Lu H.
europepmc   +1 more source

CHICK CHEMISTRY AGAINST FRIEDRICH¿S ATAXIA: HOW TO PREPARE OLIGONUCLEOTIDE-PEPTIDE CONJUGATES AND NOT TO DIE IN THE ATTEMPT.

CONFERENCIA.
openaire   +1 more source

Oligomerization of Non‐Activated Nucleotides Under Hot Acidic Wet–Dry Cycling Without Catalytic Agents

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Oligonucleotides form spontaneously through hot wet‐dry cycling of pure non‐activated nucleotides. No catalytic agents were added, and pH was naturally buffered by the nucleotides. Oligonucleotide formation was confirmed and quantified using mass spectrometry, spectroscopy and electrophoresis, establishing a solid baseline for the intrinsic extent of ...
Simon H. J. Eiby, Morten J. Bjerrum, Bálint Hajdu, Laura Da Silva, Peter W. Thulstrup, Tue Hassenkam   +5 more
wiley   +1 more source

One-Pot Enzymatic ADDing of Click Chemistry Handles for Protein Immobilization and Bioconjugation of Small and Biomolecules. [PDF]

Bioconjug Chem
Widodo WS, Fan X, Fürst MJLJ.
europepmc   +1 more source

Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang, Sean P. Giblin, James E. Pease   +2 more
wiley   +1 more source

Peptide-Oligonucleotide Conjugates: Catalytic Preparation in Aqueous Solution or On-Column. [PDF]

Curr Protoc
Gras M, Smietana M, Adler P.
europepmc   +1 more source

Comprehensive Biophysical Profiling Evidences Self‐Oligomerization of Bacterially Expressed Pc Protein

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid, Sabin Prajapati, Ghazaleh Alamdari, Kai Tittmann, Selin Kara   +4 more
wiley   +1 more source