Results 181 to 190 of about 651,747 (238)

Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting. [PDF]

Molecules
Dmitriev NA, Chernov PV, Gongadze IS, Kovchina VI, Ivanov VN, Gusev AE, Shilovskiy IP, Kofiadi IA, Khaitov MR.   +8 more
europepmc   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Antibody-oligonucleotide conjugates: an emerging modality for precision RNA therapeutics. [PDF]

Antib Ther
Yu CH, Ha SYY, An Z, Tsuchikama K, Li W.
europepmc   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Multicomponent Stapling of Glucagon-Like Peptide-1 Enables Receptor-Guided PROTAC Delivery. [PDF]

Angew Chem Int Ed Engl
Venne JL, Krajcovicova S, Davies G, Bolt H, Revell J, Spring DR.   +5 more
europepmc   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Improving the Cellular Accumulation of Folate-Conjugated Fully Chemically Modified siRNAs via 3' Terminal Conjugation. [PDF]

ACS Omega
Motosawa K, Iwano J, Harumoto T, Yabuuchi H, Hatanaka K, Koda Y, Kubo T, Kodaira H, Uehara K.   +8 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Synthesis and Characterization of Thermostable Antimicrobial Peptide-DNAzyme Conjugates for the Proof-of-Concept Detection of <i>E. coli</i>. [PDF]

ACS Omega
Mutter N, Savini F, Ban Ž, Saftić DP, Hloušek-Kasun A, Ahmadi Y, Bertoša B, Piantanida I, Barišić I.   +8 more
europepmc   +1 more source

Orthogonal Chemistry Enables Precision Nanoparticle Cofunctionalization for Tuning Immune Stimulation and Antigen Presentation. [PDF]

Biomacromolecules
Heiler AJ, McClain CA, Lucas SN, He GZ, Finn MG, Thomas SN.   +5 more
europepmc   +1 more source