Results 181 to 190 of about 20,124 (257)

A <i>Chlamydia trachomatis</i> CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model. [PDF]

Front Immunol
Bettin L, Unterweger C, Dippel M, Borysova T, Stadler M, Harris J, Rozzelle J, Arroyo D, Fairman J, Poston TB, Perouzel E, Lioux T, Hernandez-Franco JF, HogenEsch H, Buzanich-Ladinig A, Darville T, Käser T.   +16 more
europepmc   +1 more source

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg, Merve Demir, Karina Cedeno, Sheila S. David, Martin P. Horvath   +4 more
wiley   +1 more source

Defined Nylon Oligomers Enable Mechanistic Insight Into Enzymatic Polyamide Depolymerization

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
The remarkable progress in enzymatic polyester depolymerization has demonstrated the potential of biocatalysis for sustainable polymer recycling. In contrast, enzymatic polyamide (PA) degradation remains poorly understood, largely due to the lack of defined and accessible model substrates.
Sukmanita Dewi, Hendrik Puetz, Ulrich Schwaneberg, Laura Hartmann   +3 more
wiley   +1 more source

A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates. [PDF]

Anal Chem
Song Z, Yuan L.
europepmc   +1 more source

Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley   +1 more source

Antimicrobial Peptide Papiliocin-Carbon Nanotube Hybrids: Potential Dual-Action Agents for Antimicrobial Activity and Apoptotic Cancer Cell Death. [PDF]

Molecules
Zacheilas K, Margariti M, Pissia MA, Papi RM.   +3 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy. [PDF]

Adv Sci (Weinh)
Zhao X, Zhou Q, Li M, Zou W, Zhang Z, Shi J, Liu J.   +6 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Recent developments in the delivery of peptide nucleic acids (PNAs). [PDF]

RSC Chem Biol
Sarkar S, Murthy N.
europepmc   +1 more source