Results 1 to 10 of about 853 (171)

Review of the novel antifungal drug olorofim (F901318) [PDF]

BMC Infectious Diseases
There is clearly a need for novel antifungal agents, not only concerning spectrum, but also oral bioavailability, tolerability, and drug-drug interactions.
Yuri Vanbiervliet, Tine Van Nieuwenhuyse, Robina Aerts, Katrien Lagrou, Isabel Spriet, Johan Maertens   +5 more
doaj   +5 more sources

Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species. [PDF]

PLoS ONE, 2023
Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A,
Corinne Pinder, Ressa Lebedinec, Tim P Levine, Mike Birch, Jason D Oliver   +4 more
doaj   +3 more sources

Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm [PDF]

Medical Mycology Case Reports
Disseminated Lomentospora prolificans infection typically occurs in immunocompromised hosts and is almost universally fatal. We describe a case of L.
Robert Hand, J. Owen Robinson, Paul Cannell, Robert Larbalestier, Thomas Gliddon, Peter Boan   +5 more
doaj   +2 more sources

Bury my axe in wounded knee: A case of native knee septic arthritis caused by multidrug resistant Lomentospora prolificans [PDF]

Medical Mycology Case Reports
A 39-year-old male presenting with swelling and pain in the left knee after traumatic injury was diagnosed with rapidly progressive septic arthritis of the knee due to pan-resistant Lomentospora prolificans. While L. prolificans is an environmental mold,
Weston Carpenter, Catherine Pulaski, Alexander Hahn, Brenton Nash, Michael Sobieraj, Jeffrey Aeschlimann, Lisa M. Chirch   +6 more
doaj   +2 more sources

In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents [PDF]

Journal of Fungi, 2021
Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being developed at
Ourania Georgacopoulos, Natalie S. Nunnally, Eric M. Ransom, Derek Law, Mike Birch, Shawn R. Lockhart, Elizabeth L. Berkow   +6 more
doaj   +3 more sources

Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis [PDF]

JHLT Open
Redo-bilateral lung transplant in previous heart-lung transplant is a rare operation. We describe our surgical and medical management experience with a heart-lung transplant recipient who developed chronic lung allograft dysfunction and invasive ...
Akshay Chauhan, MBBS, Nischal Ranganath, MD, PhD, John P. Scott, MD, Paschalis Vergidis, MD, Anja C. Roden, MD, Philip J. Spencer, MD, Mauricio A. Villavicencio, MD, Richard C. Daly, MD, Sahar A. Saddoughi, MD, PhD   +8 more
doaj   +2 more sources

Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient [PDF]

Medical Mycology Case Reports
Trichoderma species are emerging as pathogens, causing invasive fungal infections, particularly in immunocompromised individuals. We report the case of a 61-year-old neutropenic female with hepatosplenic T-cell lymphoma and profound neutropenia, who ...
Yuri Vanbiervliet, Robina Aerts, Ellen Boon, Toine Mercier, Ann-Sophie Jacob, Marijke Peetermans, Koen Debackere, Katrien Lagrou, Johan Maertens   +8 more
doaj   +2 more sources

Invasive Pulmonary Aspergillosis in Non-Neutropenic Patients: An Evolving Clinical Paradigm [PDF]

Diagnostics
Invasive pulmonary aspergillosis (IPA), traditionally associated with severe immunosuppression and neutropenia, is increasingly reported among non-neutropenic patients.
Rocco Morena, Helen Linda Morrone, Francesca Serapide, Alessandro Russo   +3 more
doaj   +2 more sources

Non-Aspergillus molds [PDF]

JHLT Open
Non-Aspergillus molds, including Mucorales, Scedosporium, Lomentospora, and Fusarium species, are a significant cause of morbidity and mortality in heart and lung transplant recipients.
Emily M. Eichenberger, MD, MHS, Maria Alejandra Mendoza, MD, John W. Baddley, MD, MSPH   +2 more
doaj   +2 more sources

Promising antimycotics for the treatment of invasive infections [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
This paper provides a review of the largest studies (over the period of 2018 to 2023) of promising novel antimycotics and their possible role in the treatment of invasive mycoses, including infections caused by resistant Candida and Aspergillus isolates.
Ortenberg E.А.
doaj   +1 more source