Results 11 to 20 of about 49,863 (275)

Molecular pathways driving omeprazole nephrotoxicity

Redox Biology, 2020
Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole
Miguel Fontecha-Barriuso, Diego Martín-Sanchez, Julio M. Martinez-Moreno, Daniela Cardenas-Villacres, Susana Carrasco, Maria D. Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana B. Sanz   +8 more
doaj   +2 more sources

Omeprazole Treatment Enhances Nitrogen Use Efficiency Through Increased Nitrogen Uptake and Assimilation in Corn

Frontiers in Plant Science, 2019
Omeprazole is a selective proton pump inhibitor in humans that inhibits the H+/K+-ATPase of gastric parietal cells. Omeprazole has been recently shown to act as a plant growth regulator and enhancer of salt stress tolerance.
Michael James Van Oosten, Emilia Dell’Aversana, Alessandra Ruggiero, Valerio Cirillo, Yves Gibon, Pasqualina Woodrow, Albino Maggio, Petronia Carillo   +7 more
doaj   +2 more sources

Clopidogrel with or without Omeprazole in Coronary Artery Disease [PDF]

New England Journal of Medicine, 2010
Deepak L. Bhatt, Byron Cryer, Charles F. Contant, Marc Cohen, Fernando Laņas, Thomas J. Schnitzer, Thomas Shook, Pablo Lapuerta, Mark A. Goldsmith, Loren Laine, Benjamin M. Scirica, Sabina A. Murphy, Christopher P. Cannon   +12 more
openalex   +2 more sources

Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation

Bioscience Reports, 2021
The curative effect for patients with advanced gastric cancer is still unsatisfactory. Proton pump inhibitors could be a promising treatment strategy that could sensitize gastric cancer cells to antitumor drugs further; however, the underlying molecular ...
S. Feng, G. Qiu, Lihong Yang, Lihua Feng, Xin Fan, Fang Ren, Kaida Huang, Yide Chen   +7 more
semanticscholar   +1 more source

Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage

The FEBS Journal, 2021
Under physiological conditions, cells produce low basal levels of reactive oxygen species (ROS); however, in pathologic conditions ROS production increases dramatically, generating high concentrations of toxic unsaturated aldehydes.
Luis Francisco Calleja, Belem Yoval-Sánchez, Luz Hernández‐Esquivel, J. Gallardo-Pérez, Marcela Sosa‐Garrocho, Álvaro Marín-Hernández, R. Jasso-Chávez, M. Macías-Silva, J. Rodríguez-Zavala   +8 more
semanticscholar   +1 more source

Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC

Clinical Cancer Research, 2021
Purpose: Fatty acid synthase (FASN) is overexpressed in 70% of operable triple-negative breast cancer (TNBC) and is associated with poor prognosis. Proton pump inhibitors selectively inhibit FASN activity and induce apoptosis in TNBC cell lines. Patients
S. Sardesai, Alexandra Thomas, C. Gallagher, F. Lynce, Y. Ottaviano, T. Ballinger, B. Schneider, A. Storniolo, Amber Bauchle, S. Althouse, S. Perkins, A. Masters, R. Stratford, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang, K. Miller   +16 more
semanticscholar   +1 more source

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Heliyon, 2022
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety.
Harini Sri Rethinavel, Divya Bharathi Selvaraj, Sathya Jeevitha Balakrishnan, Jemi Feiona Vergil Andrews, Jerly Helan Mary Joseph, Mahesh Kandasamy   +5 more
doaj   +1 more source

Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial. Since pancreatic tumours are highly chemoresistant, a logical step would be to investigate the
Andrej Udelnow, Andreas Kreyes, Stefan Ellinger, Katharina Landfester, Paul Walther, Thomas Klapperstueck, Johannes Wohlrab, Doris Henne-Bruns, Uwe Knippschild, Peter Würl   +9 more
doaj   +1 more source

Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach

Pharmaceutics, 2022
Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics of
Kaifeng Chen, Ping Luo, Shaihong Zhu, Yaqi Lin, Nan Yang, Shuqi Huang, Qin Ding, Liyong Zhu, Qi Pei   +8 more
doaj   +1 more source

Dietary Prebiotics Modulate Omeprazole-Induced Alterations in the Gut Microbial Signature. [PDF]

Mol Nutr Food Res
Dietary prebiotic sources such as blueberries and strawberries may help improve proton pump inhibitor (PPI)‐induced gut dysbiosis. These berries represent a promising nutritional strategy for mitigating PPI‐associated gut dysbiosis and inflammation. ABSTRACT Proton pump inhibitors (PPIs) are commonly used to treat heartburn and acid‐related disorders ...
Buccola MJ, Satheesh Babu AK, Paz HA, Porter ND, Srinivasan H, Ricks RL, Rosquist K, Torres JL, Zhong Y, Jalili T, Wankhade UD, Anandh Babu PV.   +11 more
europepmc   +2 more sources