Results 21 to 30 of about 73,909 (338)

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect? [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose: To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.
Rosângela Lucinda Rocha Monteiro, Maria Aparecida Marchesan Rodrigues Kobayasi, Marina Rachel de Araujo, Dafny Rocha Monteiro, Nelson Adami Andreollo   +4 more
doaj   +1 more source

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Heliyon, 2022
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety.
Harini Sri Rethinavel, Divya Bharathi Selvaraj, Sathya Jeevitha Balakrishnan, Jemi Feiona Vergil Andrews, Jerly Helan Mary Joseph, Mahesh Kandasamy   +5 more
doaj   +1 more source

Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial. Since pancreatic tumours are highly chemoresistant, a logical step would be to investigate the
Andrej Udelnow, Andreas Kreyes, Stefan Ellinger, Katharina Landfester, Paul Walther, Thomas Klapperstueck, Johannes Wohlrab, Doris Henne-Bruns, Uwe Knippschild, Peter Würl   +9 more
doaj   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Omeprazole use and risk of chronic kidney disease evolution

PLoS ONE, 2020
Rationale, aims and objectives In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide.
J. V. M. Guedes, J. A. Aquino, Tássia Lima Bernardino Castro, Flávio Augusto de Morais, A. Baldoni, V. S. Belo, Alba Otoni   +6 more
semanticscholar   +1 more source

Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach

Pharmaceutics, 2022
Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics of
Kaifeng Chen, Ping Luo, Shaihong Zhu, Yaqi Lin, Nan Yang, Shuqi Huang, Qin Ding, Liyong Zhu, Qi Pei   +8 more
doaj   +1 more source

Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys

Pharmaceuticals, 2022
The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor.
Mohammed Z. Nasrullah, Khalid Eljaaly, Thikryat Neamatallah, Usama A. Fahmy, Abdulmohsin J. Alamoudi, Hussain T. Bakhsh, Ashraf B. Abdel-Naim   +6 more
doaj   +1 more source

Omeprazole-induced galactorrhea in kidney transplant patients—a case report

Journal of Medical Case Reports, 2022
Background Omeprazole belongs to the pharmacological classifications of proton pump inhibitors and is a widely used medicine. All proton pump inhibitors have a common mechanism of action and are prodrugs that require activation in an acidic environment ...
Choki Dorji, Farruk Ahammed Robin, Kesara Na-Bangchang   +2 more
doaj   +1 more source

Antioxidant properties of omeprazole [PDF]

FEBS Letters, 1996
Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 μM at pH
LAPENNA, Domenico, de Gioia S, Ciofani G, Festi D, Cuccurullo F.   +4 more
openaire   +4 more sources

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources