Results 51 to 60 of about 71,004,447 (289)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ENSEÑANZA DE LA PSICOLOGÍA CLÍNICA CONDUCTUAL, PRESENCIAL VS. EN LÍNEA: LA IMPORTANCIA DEL DISEÑO INSTRUCCIONAL [PDF]
Acta Colombiana de Psicología, 2009 Since the origins of psychotherapy, interest has emerged in identifying the best training strategies for professional therapists. Nowadays, in the Knowledge Era, with the availability of new interactive Information and Communication Technologies, new ...
Peñalosa-Castro, Eduardo +1 more
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Information Research: An International Electronic Journal, 1997 Educationalists worldwide are seeking to adopt on-line systems to improve their course presentations. This raises a number of issues, about how these on-line systems can best be integrated and also what structures and resources need to be put in place to
Tina Wilson, Denise Whitelock
doaj
On-line learning from search failures [PDF]
Machine Learning, 1994 Learning by explaining failures and avoiding similar ones thereafter is an attractive way to speed up problem solving. However, previous methods for explanation-based learning from failure can take too long to detect failures, explain them, or test the learned rules.
Neeraj Bhatnagar, Jack Mostow
openaire +3 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Using a NLSI to deliver the Effective Learning Programme: problems and practicalities
Information Research: An International Electronic Journal, 1997 In 1996 the University of Lincolnshire and Humberside implemented its Effective Learning programme (ELP). This is delivered by a Networked Learning Support Intranet (NLSI).
Bob Hunter
doaj
Achievement and Satisfaction in Blended Learning versus Traditional General Health Course Designs
International Journal for the Scholarship of Teaching and Learning, 2009 Blended learning is a hybrid of classroom and on-line learning that includes some of the conveniences of on-line courses without the complete loss of face-to-face tact.
Bridget Melton +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source