Results 41 to 50 of about 5,473 (218)

The Mbam drainage system and onchocerciasis transmission post ivermectin mass drug administration (MDA) campaign, Cameroon.

PLoS Neglected Tropical Diseases, 2021
BackgroundThe impact of large scale Mass Drug Adminstration (MDA) of ivermectin on active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O. volvulus is of great importance for onchocerciasis control programmes.
Raphael Awah Abong, Glory Ngongeh Amambo, Ali Ahamat Hamid, Belinda Agbor Enow, Amuam Andrew Beng, Franck Noel Nietcho, Theobald Mue Nji, Abdel Jelil Njouendou, Manuel Ritter, Mathias Eyong Esum, Kebede Deribe, Jerome Fru Cho, Fanny Fri Fombad, Peter Ivo Enyong, Catherine Poole, Kenneth Pfarr, Achim Hoerauf, Clotilde Carlow, Samuel Wanji   +18 more
doaj   +1 more source

Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy

Epilepsia Open, Volume 10, Issue 1, Page 361-367, February 2025.
Abstract Onchocerciasis, commonly known as river blindness, is a neglected tropical disease caused by the parasite Onchocerca volvulus. It can lead to blindness and visual impairment. Studies have also demonstrated a link between onchocerciasis and epilepsy, with there being a correlation between onchocerciasis endemicity and epilepsy prevalence ...
Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Mohammad Sharifzadeh, Ahmad Reza Dehpour   +4 more
wiley   +1 more source

Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa.

PLoS Neglected Tropical Diseases, 2014
BackgroundEpilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE ...
Gathoni Kamuyu, Christian Bottomley, James Mageto, Brett Lowe, Patricia P Wilkins, John C Noh, Thomas B Nutman, Anthony K Ngugi, Rachael Odhiambo, Ryan G Wagner, Angelina Kakooza-Mwesige, Seth Owusu-Agyei, Kenneth Ae-Ngibise, Honorati Masanja, Faith H A Osier, Peter Odermatt, Charles R Newton, Study of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group   +17 more
doaj   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

Research for new drugs for elimination of onchocerciasis in Africa

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa. Onchocerciasis control was initiated in West Africa in 1974 with vector control,
Annette C. Kuesel
doaj   +1 more source

Structures of Trichomonas vaginalis macrophage migratory inhibitory factor

Acta Crystallographica Section F, Volume 80, Issue 12, Page 341-347, December 2024.
The production, crystallization and three crystal structures of macrophage migratory inhibitory factor from T. vaginalis are reported.The unicellular parasitic protozoan Trichomonas vaginalis causes trichomoniasis, the most prevalent nonviral sexually transmitted disease globally. T.
Aruesha Srivastava, Aryana Nair, Omolara C. O. Dawson, Raymond Gao, Lijun Liu, Justin K. Craig, Kevin P. Battaile, Elizabeth K. Harmon, Lynn K. Barrett, Wesley C. Van Voorhis, Sandhya Subramanian, Peter J. Myler, Scott Lovell, Oluwatoyin A. Asojo, Rabih Darwiche   +14 more
wiley   +1 more source

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.

PLoS Pathogens, 2021
Current mass drug administration (MDA) programs for the treatment of human river blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus rely on ivermectin, an anthelmintic originally developed for animal health.
Jürgen Krücken, Lindy Holden-Dye, Jennifer Keiser, Roger K Prichard, Simon Townson, Benjamin L Makepeace, Marc P Hübner, Steffen R Hahnel, Ivan Scandale, Achim Harder, Daniel Kulke   +10 more
doaj   +1 more source

Synthesizing environmental, epidemiological and vector and parasite genetic data to assist decision making for disease elimination

Molecular Ecology, Volume 33, Issue 11, June 2024.
Abstract We present a framework for identifying when conditions are favourable for transmission of vector‐borne diseases between communities by incorporating predicted disease prevalence mapping with landscape analysis of sociological, environmental and host/parasite genetic data.
Himal Shrestha, Karen McCulloch, Rebecca H. Chisholm, Samuel K. Armoo, Francis Veriegh, Neha Sirwani, Katie E. Crawford, Mike Y. Osei‐Atweneboana, Warwick N. Grant, Shannon M. Hedtke   +9 more
wiley   +1 more source

Phylogenetic relationships of the Wolbachia of nematodes and arthropods. [PDF]

PLoS Pathogens, 2006
Wolbachia are well known as bacterial symbionts of arthropods, where they are reproductive parasites, but have also been described from nematode hosts, where the symbiotic interaction has features of mutualism.
Katelyn Fenn, Claire Conlon, Martin Jones, Michael A Quail, Nancy E Holroyd, Julian Parkhill, Mark Blaxter   +6 more
doaj   +1 more source