Results 41 to 50 of about 13,454 (262)

The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness [PDF]

, 2017
Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca ...
Basáñez, Maria-Gloria, Boussinesq, Michel, Chesnais, Cédric, Chippaux, Jean-Philippe, Ernould, Jean-Christophe, Fang, Hanwei, Garcia, André, Gardon, J., Kamgno, Joseph, Pion, Sébastien, Ranque, Stephane, Tchatchueng-Mbougua, Jules Brice, Walker, Martin   +12 more
core   +3 more sources

Extracellular Onchocerca-derived small RNAs in host nodules and blood

Parasites & Vectors, 2015
Background microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of murine and ...
Juan F Quintana, Benjamin L Makepeace, Simon A Babayan, Alasdair Ivens, Kenneth M Pfarr, Mark Blaxter, Alexander Debrah, Samuel Wanji, Henrietta F Ngangyung, Germanus S Bah, Vincent N Tanya, David W Taylor, Achim Hoerauf, Amy H Buck   +13 more
doaj   +1 more source

Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda—Clinical, EEG and Brain Imaging Features

Frontiers in Neurology, 2021
Globally, epilepsy is the most common chronic neurological disorder. The incidence in sub-Saharan Africa is 2-3 times higher than that in high income countries.
Rodney Ogwang, Rodney Ogwang, Rodney Ogwang, Albert Ningwa, Albert Ningwa, Pamela Akun, Pamela Akun, Paul Bangirana, Ronald Anguzu, Ronald Anguzu, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro, Richard Idro, Richard Idro   +21 more
doaj   +1 more source

Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus. [PDF]

, 2016
BACKGROUND: The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and in some foci, quarterly) mass ...
Basanez, MG, Borges, D, Botto, C, Camacho, O, Coronel, P, Cortez, J, Escalona, M, Flores, J, Frontado, H, Graterol, B, Grillet, ME, Guerra, F, Margeli, H, Morales, AL, Noya-Alarcón, O, Rodriguez, MA, Ríos, D, Tovar, Y, Unnasch, TR, Villamizar, NJ, Vivas-Martínez, S   +20 more
core   +2 more sources

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

PLoS Neglected Tropical Diseases, 2017
Stephen Doyle, Catherine Bourguinat, Hugues C Nana-Djeunga   +2 more
exaly   +3 more sources

Recombinant expression systems: the obstacle to helminth vaccines? [PDF]

, 2007
A
Claerebout, Edwin, De Maere, Veerle, Geldhof, Peter, Vercruysse, Jozef   +3 more
core   +2 more sources

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal [PDF]

, 2017
The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes ...
Basáñez, M-G, Bottomley, C, De Vlas, S J, Diawara, L, Dixon, M A, Stolk, W A, Traoré, M O, Walker, M   +7 more
core   +7 more sources

Elimination of onchocerciasis in Ecuador: findings of post-treatment surveillance. [PDF]

, 2018
BACKGROUND: The Esmeraldas focus of onchocerciasis in Ecuador expanded geographically during the 1980s and was associated with severe ocular and skin disease.
AG Guevara, AJ Shelley, AJ Shelley, AJ Shelley, B Thylefors, CR Katholi, EW Cupp, EW Cupp, HL Carvajal, JC Vieira, M Arzube, M Charalambous, M Charalambous, MA Rodríguez-Pérez, Mario A. Rodriguez-Perez, MG Basanez, Philip J. Cooper, PJ Cooper, PJ Cooper, R Lovato, Raquel Lovato, RC Collins, RC Collins, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RJ Hay, Roberto Proaño, Ronald H. Guderian, S Wetten, Thomas Unnasch, WHO, WS Procunier, WS Procunier, Ángel Guevara   +38 more
core   +1 more source

Simuliidae and the transmission and control of human Onchocerciasis in Latin America

Cadernos de Saúde Pública, 1991
Factors that affect the propensity of a simuliid species to act as a host to Onchocerca volvulus and to naturally transmit this filarial worm in nature are discussed.
A. J. Shelley
doaj   +1 more source

Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi

Frontiers in Cellular and Infection Microbiology, 2022
Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode Onchocerca volvulus. The infection can cause irreversible visual impairment or blindness and stigmatizing dermatitis.
Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Sara Lustigman   +3 more
doaj   +1 more source