Results 1 to 10 of about 7,538 (152)

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Assmus F, Adehin A, Hoglund RM, Nyaulingo G, Mbarak H, Jongo S, Ackermann E, Reus E, Keiser J, Rocha FBDS, Specht S, Scandale I, Tarning J.   +12 more
europepmc   +2 more sources

Epidemiology and Risks Survey of Onchocerca volvulus Infection in Igbo-Eze North Local Government Area, Enugu State, Nigeria [PDF]

Tropical Medicine and Infectious Disease
Background: An epidemiological survey of Onchocerca volvulus infection and onchocerciasis in Igbo-Eze North Local Government Area, Enugu State, Nigeria, was undertaken to assess its distribution and risks among individuals in the area.
Ifeoma Esther Aniaku, Grace Chinenye Onyishi, Chigozie Godwin Nwosu, Godwin Ikechukwu Ngwu, Chioma Janefrances Okeke, Uche Boniface Oraneli, Chidiebere Agha Otuu, Nicholas Arome Akobe, Augustine Uchechukwu Nnama, Kyrian Ikenna Onah   +9 more
doaj   +2 more sources

Malaria in onchocerciasis-endemic populations: patterns in two districts in the Oti and Volta regions of Ghana [PDF]

BMC Infectious Diseases
Background In Ghana and many other sub-Saharan African countries, onchocerciasis and malaria are common infectious diseases that affect people of all ages.
Bright Ampadu, Samuel Osei, Yvonne Ashong, Dziedzom K. de Souza, Ewurama Dedea Ampadu Owusu   +4 more
doaj   +2 more sources

Current Gaps in Survey Design and Analysis for Molecular Xenomonitoring of Vector-Borne Neglected Tropical Diseases: A Systematic Review. [PDF]

Trop Med Int Health
ABSTRACT Objectives Molecular xenomonitoring is a surveillance method for vector‐borne diseases where vectors are tested for molecular pathogen markers. Testing is typically on pools (groups) of vectors. Molecular xenomonitoring is a sensitive and efficient complement to human‐based surveillance.
McLure A, Alamnia T, Xu Z, Lau CL, Mayfield HJ.   +4 more
europepmc   +2 more sources

Onchocerciasis and non-communicable diseases in the Bafut Health District, Cameroon: Knowledge, attitudes, and practices towards community-directed treatment with ivermectin. [PDF]

PLoS Neglected Tropical Diseases
BackgroundOnchocerciasis remains a public health problem in Cameroon despite years of community-directed treatment with ivermectin (CDTI). Its persistence increasingly overlaps with the rising burden of non-communicable diseases (NCDs).
Irene U Ajonina-Ekoti, Promise A Aghaeze, Joan Ebanga, Theophilus A Ekoti, Tiburce Gangue, Beri A Gariba, Moses A Mbanwi, Adolph A Fozao, Carine K Nfor, Mbunkah D Achukwi, Marcelus U Ajonina   +10 more
doaj   +2 more sources

Repurposing of Anti-Infectives for the Management of Onchocerciasis Using Machine Learning and Protein Docking Studies [PDF]

Bioinformatics and Biology Insights
There is a need to improve the discovery of new drugs for neglected tropical diseases (NTDs), as the lack of financial incentives has slowed their development. Currently, ivermectin and moxidectin are used in the management of onchocerciasis.
Cyril Tetteh, Andy Andoh Mensah, Bernice Ampomah, Mahmood B Oppong, Michael Lartey, Paul Owusu Donkor, Kwabena FM Opuni, Lawrence A Adutwum   +7 more
doaj   +2 more sources

Epidemiological assessment of onchocerciasis in previously unmapped villages for ivermectin distribution in Fer-Fer District, Somali Regional State, Eastern Ethiopia [PDF]

BMC Infectious Diseases
Background Onchocerciasis is endemic to parts of Ethiopia; however, epidemiological data are lacking in some regions. This study aimed to assess the prevalence, intensity, and risk factors of onchocerciasis in previously unmapped villages in the Fer-Fer ...
Dek Kahin Yosef, Barwaqo Saleban Awil, Ahmed Saeed Ismail, Mohamed Ahmed Hassan   +3 more
doaj   +2 more sources

Health-related quality of life and associated factors among Onchocerciasis patients in southeast Nigeria: A cross-sectional comparative study

PLoS Neglected Tropical Diseases, 2022
Introduction Onchocerciasis, a neglected tropical disease of public health importance, causes chronic morbidity and severe disability that may impact on health-related quality of life (HRQoL) of the infected people.
Adah E. Otache, Ifeyinwa L. Ezenwosu, Edmund N. Ossai, Elias C. Aniwada, Emmanuel A. Nwobi, Benjamin SC. Uzochukwu   +5 more
doaj   +2 more sources

A cross-sectional study of Simulium damnosum sensu lato breeding sites and species distribution in Sudan savanna, mixed savanna–forest and rainforest regions in Cameroon

Parasites & Vectors, 2022
Background The presence of breeding sites and distribution of species of Simulium damnosum sensu lato are critical in understanding the epidemiology of onchocerciasis and evaluating the impact of elimination interventions.
Franklin Ayisi, Naniogué Sedou, Stephanie Kouahou Dieunang, Florent Yaya, Edmond François Tchago, Cosmas Ejong Ndellejong, Benjamin Biholong, Daniel Adjei Boakye   +7 more
doaj   +1 more source

Management of onchocerciasis among adolescents in nkwanta north district of Ghana: Qualitative study of adolescents' perception, community and health system support.

PLoS Neglected Tropical Diseases, 2023
BackgroundOnchocerciasis affects the quality of life to a greater extent among affected individuals. The World Health Organization (WHO)'s Onchocerciasis Control Program (OCP) has effectively reduced the prevalence of onchocerciasis by interrupting the ...
Sitsofe Gbogbo, Hubert Amu, Robert Kokou Dowou, Martin Amogre Ayanore   +3 more
doaj   +1 more source