Results 21 to 30 of about 17,701 (235)

Why onchocerciasis transmission persists after 15 annual ivermectin mass drug administrations in South-West Cameroon

BMJ Global Health, 2021
Introduction Onchocerciasis is targeted for elimination mainly with annual community-directed treatment with ivermectin (CDTI). High infection levels have been reported in South-West Cameroon, despite ≥15 years of CDTI.
Armelle Forrer, S. Wanji, Elisabeth Dibando Obie, T. Nji, L. Hamill, Kim Ozano, Helen Piotrowski, L. Dean, A. Njouendou, Relindis Ekanya, Winston Patrick Chounna Ndongmo, Ebua Gallus Fung, Dum-Buo Nnamdi, Raphael A Abong, Amuam Andrew Beng, Mathias Esum Eyong, Bertrand L Ndzeshang, Desmond Akumtoh Nkimbeng, Samuel Teghen, Anicetus Suireng, Ernerstine Ebot Ashu, Emmanuel Kah, Michele M Murdoch, Rachael Thomson, S. Theobald, P. Enyong, J. Turner, M. Taylor   +27 more
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Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

PLoS Pathogens, 2021
Current mass drug administration (MDA) programs for the treatment of human river blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus rely on ivermectin, an anthelmintic originally developed for animal health.
J. Krücken, L. Holden-Dye, J. Keiser, R. Prichard, S. Townson, Benjamin L. Makepeace, M. Hübner, S. Hahnel, Ivan Scandale, A. Harder, D. Kulke   +10 more
semanticscholar   +1 more source

Management of onchocerciasis among adolescents in nkwanta north district of Ghana: Qualitative study of adolescents' perception, community and health system support.

PLoS Neglected Tropical Diseases, 2023
BackgroundOnchocerciasis affects the quality of life to a greater extent among affected individuals. The World Health Organization (WHO)'s Onchocerciasis Control Program (OCP) has effectively reduced the prevalence of onchocerciasis by interrupting the ...
Sitsofe Gbogbo, Hubert Amu, Robert Kokou Dowou, Martin Amogre Ayanore   +3 more
doaj   +1 more source

Computational Design and Preliminary Serological Analysis of a Novel Multi-Epitope Vaccine Candidate Against Onchocerciasis and Related Filarial Diseases

Pathogens, 2021
Onchocerciasis is a skin and eye disease that exerts a heavy socio-economic burden, particularly in sub-Saharan Africa, a region which harbours greater than 96% of either infected or at-risk populations.
R. A. Shey, S. Ghogomu, C. M. Shintouo, Francis N. Nkemngo, D. N. Nebangwa, K. Esoh, Ntang Emmaculate Yaah, Muyanui Manka'aFri, Joel Ebai Nguve, Roland Akwelle Ngwese, F. Njume, Fru Asa Bertha, L. Ayong, R. Njemini, L. Vanhamme, J. Souopgui   +15 more
semanticscholar   +1 more source

Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning

PLoS Neglected Tropical Diseases, 2021
Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across
E. Cromwell, Joshua C. P. Osborne, T. Unnasch, M. Basáñez, K. Gass, Kira A Barbre, Elex Hill, Kimberly B Johnson, Katie M. Donkers, S. Shirude, Christopher A Schmidt, V. Adekanmbi, O. Adetokunboh, M. Afarideh, E. Ahmadpour, M. Ahmed, T. Akalu, Z. Al-Aly, Fahad Mashhour Alanezi, Turki M. Alanzi, V. Alipour, C. Andrei, F. Ansari, Mustafa Geleto Ansha, Davood Anvari, Seth Christopher Yaw Appiah, J. Arabloo, B. Arnold, M. Ausloos, M. Ayanore, A. Baig, M. Banach, A. Barać, T. Bärnighausen, M. Bayati, Krittika Bhattacharyya, Z. Bhutta, S. Bibi, Ali Bijani, S. Bohlouli, Mahdi Bohluli, O. Brady, N. Bragazzi, Z. Butt, F. Carvalho, Sirshendu Chatterjee, Vijay Kumar Chattu, Soosanna Kumary Chattu, N. Cormier, Saad M A Dahlawi, G. Damiani, Farah Daoud, A. Darwesh, A. Daryani, Kebede Deribe, S. Dharmaratne, Daniel Diaz, H. Do, M. El Sayed Zaki, M. El Tantawi, Demelash Abewa Elemineh, A. Faraj, M. Fasihi Harandi, Yousef Fatahi, V. Feigin, E. Fernandes, N. Foigt, M. Foroutan, R. Franklin, M. I. Gubari, D. Guido, Yuming Guo, Arvin Haj-Mirzaian, Kanaan Hamagharib Abdullah, S. Hamidi, C. Herteliu, Hagos Degefa de Hidru, T. Higazi, Naznin Hossain, M. Hosseinzadeh, M. Househ, O S Ilesanmi, M. Ilic, I. Ilic, Usman Iqbal, S. Irvani, Ravi Prakash Jha, F. Joukar, J. Jozwiak, Z. Kabir, Leila R. Kalankesh, R. Kalhor, B. Karami Matin, S. Karimi, A. Kasaeian, T. Kavetskyy, G. Kayode, Ali Kazemi Karyani, A. G. Kelbore, Maryam Keramati, Rovshan Khalilov, E. Khan, Md Nuruzzaman Khan, K. Khatab, M. Khater, Neda Kianipour, K. T. Kibret, Y. Kim, S. Kosen, Kristopher J. Krohn, D. Kusuma, C. la Vecchia, V. Lansingh, P. Lee, K. E. LeGrand, Shanshan Li, J. Longbottom, H. Magdy Abd El Razek, Muhammed Magdy Abd El Razek, A. Maleki, A. Mamun, A. Manafi, N. Manafi, M. Mansournia, F. R. Martins-Melo, M. Mazidi, C. McAlinden, Birhanu Geta Meharie, W. Mendoza, E. Mengesha, D. T. Mengistu, S. T. Mereta, T. Meštrović, T. Miller, M. Miri, M. Moghadaszadeh, A. Mohammadian-Hafshejani, R. Mohammadpourhodki, S. Mohammed, Salahuddin Mohammed, M. Moradi, R. Moradzadeh, P. Moraga, J. Mosser, M. Naderi, Ahamarshan Jayaraman Nagarajan, G. Naik, I. Negoi, C. Nguyen, H. Nguyen, T. H. Nguyen, Rajan Nikbakhsh, Bogdan Oancea, T. Olagunju, A. Olagunju, Ahmed Omar Bali, O. Onwujekwe, A. Pana, H. Pourjafar, F. Rahim, Mohammad Hifz Ur Rahman, P. Rathi, S. Rawaf, D. Rawaf, Reza Rawassizadeh, S. Resnikoff, M. Reta, A. Rezapour, Enrico Rubagotti, S. Rubino, E. Sadeghi, A. Saghafipour, S. M. Sajadi, A. Samy, R. Sarmiento-Suárez, M. Sawhney, Megan F Schipp, A. Shaheen, M. Shaikh, M. Shamsizadeh, K. Sharafi, Aziz Sheikh, B. Shetty, J. Shin, K. M. Shivakumar, B. Simonetti, Jasvinder A. Singh, Eirini Skiadaresi, A. Soheili, Shahin Soltani, E. Spurlock, M. Sufiyan, T. Tabuchi, Leili Tapak, Robert L. Thompson, A. Thomson, Eugenio Traini, B. Tran, I. Ullah, Saif Ullah, C. Uneke, B. Unnikrishnan, O. Uthman, Natalie V. S. Vinkeles Melchers, F. Violante, H. F. Wolde, Tewodros Eshete Wonde, Tomohide Yamada, S. Yaya, Vahid Yazdi-Feyzabadi, Paul S. F. Yip, N. Yonemoto, Hebat-Allah S. A. Yousof, Chuanhua Yu, Yong Yu, H. Yusefzadeh, Leila Zaki, S. Zaman, M. Zamanian, Zhi-Jiang Zhang, Yunquan Zhang, A. Ziapour, Simon Iain Hay, D. Pigott   +223 more
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The burden of skin disease and eye disease due to onchocerciasis in countries formerly under the African Programme for Onchocerciasis Control mandate for 1990, 2020, and 2030

PLoS Neglected Tropical Diseases, 2021
Background Onchocerciasis (“river blindness”) can cause severe morbidity, including vision loss and various skin manifestations, and is targeted for elimination using ivermectin mass drug administration (MDA).
Natalie V. S. Vinkeles Melchers, W. Stolk, W. van Loon, Bélen Pedrique, R. Bakker, M. Murdoch, S. D. de Vlas, L. Coffeng   +7 more
semanticscholar   +1 more source

A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy

Open Forum Infectious Diseases, 2020
To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon.
C. Chesnais, C. Bizet, Jérémy T. Campillo, W. Njamnshi, J. Bopda, P. Nwane, S. Pion, A. Njamnshi, M. Boussinesq   +8 more
semanticscholar   +1 more source

‘Slash and clear’ vector control for onchocerciasis elimination and epilepsy prevention: a protocol of a cluster randomised trial in Cameroonian villages

BMJ Open, 2021
Introduction Onchocerciasis, caused by the filarial nematode Onchocerca volvulus, remains endemic in Cameroon despite decades of community-directed treatment with ivermectin (CDTI).
J. S. Siewe Fodjo, M. Vieri, L. Ngarka, W. Njamnshi, L. Nfor, M. Mengnjo, A. Hendy, P. Enyong, Dennis Palmer, M. Basáñez, R. Colebunders, Alfred K. Njamnshi   +11 more
semanticscholar   +1 more source

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Scientific Reports, 2019
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and
R. A. Shey, S. Ghogomu, K. Esoh, Neba Derrick Nebangwa, C. M. Shintouo, Nkemngo Francis Nongley, B. F. Asa, Ferdinand Njume Ngale, L. Vanhamme, J. Souopgui   +9 more
semanticscholar   +1 more source

Onchocerciasis Elimination: Progress and Challenges

Research and Reports in Tropical Medicine, 2020
Onchocerciasis is a parasitic infection caused by the filarial nematode Onchocerca volvulus and transmitted through the bites of black flies of the genus Similium that breed in rivers and streams.
T. Lakwo, D. Oguttu, Tony O Ukety, R. Post, D. Bakajika   +4 more
semanticscholar   +1 more source