Results 31 to 40 of about 28,700 (244)

Computational Design and Preliminary Serological Analysis of a Novel Multi-Epitope Vaccine Candidate Against Onchocerciasis and Related Filarial Diseases

Pathogens, 2021
Onchocerciasis is a skin and eye disease that exerts a heavy socio-economic burden, particularly in sub-Saharan Africa, a region which harbours greater than 96% of either infected or at-risk populations.
R. A. Shey, S. Ghogomu, C. M. Shintouo, Francis N. Nkemngo, D. N. Nebangwa, K. Esoh, Ntang Emmaculate Yaah, Muyanui Manka'aFri, Joel Ebai Nguve, Roland Akwelle Ngwese, F. Njume, Fru Asa Bertha, L. Ayong, R. Njemini, L. Vanhamme, J. Souopgui   +15 more
semanticscholar   +1 more source

The burden of skin disease and eye disease due to onchocerciasis in countries formerly under the African Programme for Onchocerciasis Control mandate for 1990, 2020, and 2030

PLoS Neglected Tropical Diseases, 2021
Background Onchocerciasis (“river blindness”) can cause severe morbidity, including vision loss and various skin manifestations, and is targeted for elimination using ivermectin mass drug administration (MDA).
Natalie V. S. Vinkeles Melchers, W. Stolk, W. van Loon, Bélen Pedrique, R. Bakker, M. Murdoch, S. D. de Vlas, L. Coffeng   +7 more
semanticscholar   +1 more source

Onchocerciasis Elimination: Progress and Challenges

Research and Reports in Tropical Medicine, 2020
Onchocerciasis is a parasitic infection caused by the filarial nematode Onchocerca volvulus and transmitted through the bites of black flies of the genus Similium that breed in rivers and streams.
T. Lakwo, D. Oguttu, Tony O Ukety, R. Post, D. Bakajika   +4 more
semanticscholar   +1 more source

The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination [PDF]

, 2012
Background: Neglected tropical diseases (NTDs) are a group of chronic parasitic diseases and related conditions that are the most common diseases among the 2·7 billion people globally living on less than US$2 per day.
A Alemu, A Aseffa, A Deressa, A Haileamlak, A Yami, Abraham Aseffa, AD Bryceson, Ahmed Ali, AM Dorkenoo, Asrat Hailu, AZ Zein, B Erko, B Erko, B Liese, B Yakob, BA Boatin, C Bogh, C Hanson, C Prasittisuk, C Sikorski, Central Statistical Agency [Ethiopia], ICF International, D Fekadu, DG Addiss, DH Molyneux, DH Molyneux, DR ten Eyck, E Litt, E Negera, E Negera, E Ruiz-Tiben, E Yimer, EW Price, F Demissie, F Tekola, FMOH, FMOH, FMoH, G Davey, G Davey, G Davey, G Mengistu, G Tefera, Gail Davey, GS Smith, H Birrie, H Kloos, H Kloos, J Alvar, J Alvar, JH Kolaczinski, JH Kolaczinski, JO Gyapong, K Bogel, KA Grépin, Kadu Meribo, Kebede Deribe, L Erosie, L Jemaneh, M Fekadu, M Fekadu, M Herrero, MA Brady, MC Baker, Ministry of Health, MJ Burton, MJ Taylor, N Kebede, NB Kabatereine, P Steinmann, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PM Emerson, R ter Horst, RL Pullan, RW Ashford, S Bashaye, S Brooker, S Brooker, S Cairncross, S Negash, SG Gundersen, T Wondimagegnehu, Teshome Gebre, The Carter Center, W Shiferaw, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, Y Berhane, Z Tadesse, ZA Zein   +103 more
core   +2 more sources

The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]

, 2014
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf, Agwuh, Basáñez, Basáñez, Bosshardt, Cattamanchi, Chib, Churcher, de Andrade, Debrah, Duke, Duke, Gardon, Gelman, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Mand, Mark J. Taylor, Martin Walker, María-Gloria Basáñez, Norton, Osei-Atweneboana, Plaisier, Plaisier, Roberts, Sabine Specht, Specht, Tamarozzi, Taylor, Taylor, Taylor, Taylor, Taylor, Thomas S. Churcher, van Rie, Wanji, Wearing, World Health Organization, Xia   +43 more
core   +2 more sources

Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: a focus on the children.

International Journal of Infectious Diseases, 2022
Efforts are being directed toward the elimination of onchocerciasis transmission in endemic areas with community-directed treatment with ivermectin (CDTI) in Africa, which greatly reduces onchocerciasis-associated disease. However, onchocerciasis remains
Robert Colebunders, Christoph Kaiser, Maria-Gloria Basáñez, Piero Olliaro, Tom Lakwo, Joseph Nelson Siewe Fodjo   +5 more
doaj   +1 more source

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Scientific Reports, 2019
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and
R. A. Shey, S. Ghogomu, K. Esoh, Neba Derrick Nebangwa, C. M. Shintouo, Nkemngo Francis Nongley, B. F. Asa, Ferdinand Njume Ngale, L. Vanhamme, J. Souopgui   +9 more
semanticscholar   +1 more source

A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy

Open Forum Infectious Diseases, 2020
To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon.
C. Chesnais, C. Bizet, Jérémy T. Campillo, W. Njamnshi, J. Bopda, P. Nwane, S. Pion, A. Njamnshi, M. Boussinesq   +8 more
semanticscholar   +1 more source

The impact of ivermectin on onchocerciasis in villages co-endemic for lymphatic filariasis in an area of onchocerciasis recrudescence in Burkina Faso

PLoS Neglected Tropical Diseases, 2021
In Burkina Faso, onchocerciasis was no longer a public health problem when the WHO Onchocerciasis Control Programme in West Africa closed at the end in 2002. However, epidemiological surveillance carried out from November 2010 to February of 2011, showed
A. Nikièma, L. Koala, A. Sondo, R. Post, Alain B Paré, C. Kafando, R. Kambire, B. Sow, C. Bougouma, R. Dabiré, S. Traoré   +10 more
semanticscholar   +1 more source

Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo

Parasite Epidemiology and Control, 2018
Background: Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with ...
Francois Korbmacher, Kossi Komlan, Richard G. Gantin, Wiyao P. Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T. Soboslay, Carsten Köhler   +7 more
doaj   +1 more source