Results 11 to 20 of about 250,918 (350)

[Oncogenes].

Acta medica portuguesa, 1986
C Manso
doaj   +8 more sources

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma [PDF]

Oncogene vol 24, p 7094-7104 (2005), 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +2 more sources

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

Journal of Immunology Research, 2022
Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully ...
Lei Zhu, Kai X. Zhou, Ming Z. Ma, Lin L. Yao, Yan L. Zhang, Hui Li, Chang Du, Xiao M. Yang   +7 more
doaj   +1 more source

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis

Journal of Immunology Research, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of ...
Yue Sun, Xiao-Xin Zhang, Shan Huang, Hong Pan, Yan-Zhi Gai, Yao-Qi Zhou, Lei Zhu, Hui-Zhen Nie, Dong-Xue Li   +8 more
doaj   +1 more source

HDACs/mTOR inhibitor synergizes with pyrotinib in HER2-positive pancreatic cancer through degradation of mutant P53

Cancer Cell International, 2022
Background Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among which HER2 receptor tyrosine kinase inhibitor ...
Tiebo Mao, Xiaofei Zhang, Haiyan Xu, Xiao Zhang, Weiyu Ge, Shumin Li, Jingyu Ma, Ming Yue, Shengbai Xue, Jiujie Cui, Liwei Wang   +10 more
doaj   +1 more source

Poly (N-vinylpyrrolidone) modification mitigates plasma protein corona formation on phosphomolybdate-based nanoparticles

Journal of Nanobiotechnology, 2021
Phosphomolybdate-based nanoparticles (PMo12-based NPs) have been commonly applied in nanomedicine. However, upon contact with biofluids, proteins are quickly adsorbed onto the NPs surface to form a protein corona, which induces the opsonization and ...
Youyi Yu, Behafarid Ghalandari, Guangxia Shen, Liping Wang, Xiao Liu, Aiting Wang, Sijie Li, Haiyang Xie, Xianting Ding   +8 more
doaj   +1 more source

Stat3 as an Oncogene [PDF]

Cell, 1999
STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis.
Chris Albanese, Jacqueline Bromberg, Yanxiang Zhao, Geeta Devgan, James E. Darnell, Richard G. Pestell, Melissa H. Wrzeszczynska   +6 more
openaire   +5 more sources

Oncogene Addiction [PDF]

Cancer Research, 2008
Abstract Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called “oncogene addiction,” provides a rationale for molecular targeted therapy.
I Bernard, Weinstein, Andrew, Joe
openaire   +2 more sources

FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

Journal of Translational Medicine, 2023
Purpose The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, further ...
Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li   +9 more
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Lessons to cancer from studies of leukemia and hematopoiesis

Frontiers in Cell and Developmental Biology, 2022
The starting point to describing the origin and nature of any cancer must be knowledge about how the normal counterpart tissue develops. New principles to the nature of hematopoietic stem cells have arisen in recent years.
Geoffrey Brown
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