Results 11 to 20 of about 384,141 (378)
Journal of Immunology Research, 2022 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of ...
Yue Sun +8 more
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Journal of Immunology Research, 2022 Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully ...
Lei Zhu +7 more
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Genetic factors and cancer: diagnosis, prognosis and future perspectives
Revista Ciências em Saúde, 2021 Genetics is specifically responsible for several pathologies or, at the least, it is associated with a wide range of them, either as a primary causal agent (congenital genetic diseases) or secondary, being a factor within several possible for a given ...
Fernando Russo Costa do Bomfim
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Lessons to cancer from studies of leukemia and hematopoiesis
Frontiers in Cell and Developmental Biology, 2022 The starting point to describing the origin and nature of any cancer must be knowledge about how the normal counterpart tissue develops. New principles to the nature of hematopoietic stem cells have arisen in recent years.
Geoffrey Brown
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Biomedicines, 2021 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease caused in 10% of cases by inherited mutations considered “familial”. An ever-increasing amount of evidence is showing a fundamental role for RNA metabolism in ALS pathogenesis,
Federica Rey +8 more
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Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review
Anticancer Research, 2020 Cancer is a medical condition which has a molecular basis. Proto-oncogenes are the first regulatory factors of this biological process. They act in transmitting signals, resulting as growth factors. Modifications of these genes, called oncogenes, lead to
E. Kontomanolis +11 more
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Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence
Metabolites, 2023 Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins.
Roopak Murali +7 more
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Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells
International Journal of Molecular Sciences, 2021 In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to mutation and fusion with another gene or overexpression. Generally, oncogenes are viewed as deregulating cell proliferation or suppressing apoptosis in driving ...
Geoffrey Brown
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Recent Advances in Liver Cancer Stem Cells: Non-coding RNAs, Oncogenes and Oncoproteins
Frontiers in Cell and Developmental Biology, 2020 Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide, with high morbidity, relapse, metastasis and mortality rates. Although liver surgical resection, transplantation, chemotherapy, radiotherapy and some molecular targeted ...
Juan Li, Ying Zhu, Ying Zhu
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