Results 11 to 20 of about 237,469 (282)
Journal of Immunology Research, 2022 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of ...
Yue Sun +8 more
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Global Medical Genetics, 2023 Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases ...
Datis Kalali
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Journal of Immunology Research, 2022 Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully ...
Lei Zhu +7 more
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Cells, 2021 Ever since the ubiquitin proteasome system was characterized, efforts have been made to manipulate its function to abrogate the progression of cancer. As a result, the anti-cancer drugs bortezomib, carfilzomib, and ixazomib targeting the 26S proteasome ...
Andres J. Rubio +6 more
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The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus
Dental Research Journal, 2023 Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi +3 more
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Lessons to cancer from studies of leukemia and hematopoiesis
Frontiers in Cell and Developmental Biology, 2022 The starting point to describing the origin and nature of any cancer must be knowledge about how the normal counterpart tissue develops. New principles to the nature of hematopoietic stem cells have arisen in recent years.
Geoffrey Brown
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The Journal of Pathology: Clinical Research, 2023 Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course of patients with pancreatic cancer in relation to these driver alterations has not been fully characterised in large ...
Yohei Masugi +24 more
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Biomedicines, 2021 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease caused in 10% of cases by inherited mutations considered “familial”. An ever-increasing amount of evidence is showing a fundamental role for RNA metabolism in ALS pathogenesis,
Federica Rey +8 more
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Genetic factors and cancer: diagnosis, prognosis and future perspectives
Revista Ciências em Saúde, 2021 Genetics is specifically responsible for several pathologies or, at the least, it is associated with a wide range of them, either as a primary causal agent (congenital genetic diseases) or secondary, being a factor within several possible for a given ...
Fernando Russo Costa do Bomfim
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