Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown [PDF]
Scientific Reports 6, Article number: 30245 (2016), 2017 A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-small cell lung cancer cells would sensitize the cells to
arxiv +1 more source
Ageing And Cancer As Diseases Of Epigenesis [PDF]
, 2009 Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core +2 more sources
Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells
Frontiers in Oncology, 2019 Chimeric antigen receptor modified T cells (CAR-T) therapy is an emerging immunotherapy against malignancies. However, only limited success was obtained in solid tumors.
Shengmeng Di +9 more
doaj +1 more source
CD26/dipeptidyl peptidase IV contributes to tumor metastasis in human lung adenocarcinoma
Bangladesh Journal of Pharmacology, 2013 CD26/dipeptidyl peptidase IV (DPPIV) is a 110-kDa trans-membrane ecto-enzyme that has multiple functions in humans. Previously, we established a highly metastatic human lung adenocarcinoma cell line exhibiting epithelial-mesenchymal transition (EMT) by ...
Lei Liu +10 more
doaj +1 more source
A Computational Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence across the Lifespan in the Human Population [PDF]
Bauer, Roman, Marcus Kaiser, and Elizabeth Stoll. "A Computational
Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence
across the Lifespan in the Human Population." PloS one 9.11 (2014): e111219, 2015 Glioma is the most common form of primary brain tumor. Demographically, the risk of occurrence increases until old age. Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan. Previous mathematical models explaining glioma incidence are framed in a rather abstract way, and do not directly relate
arxiv +1 more source
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
Ultrabright gap-enhanced Raman tags for high-speed bioimaging
Nature Communications, 2019 The speed of surface-enhanced Raman spectroscopy (SERS) imaging is generally limited due to low Raman signals. Here, the authors develop bright gap-enhanced Raman tags with external hot spots and demonstrate their use in fast near-infrared bioimaging.
Yuqing Zhang +4 more
doaj +1 more source
The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus
Dental Research Journal, 2023 Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi +3 more
doaj +1 more source
The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
core +1 more source
Reviewing Oncogenes and Proto-Oncogenes
International Journal of Scientific Research in Science and Technology, 2021 This article is an examination of the Reviewing oncogenes and Proto-oncogenes The scientific development and subsequent “oncogenes and Proto-oncogenes” continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists.
Nehal Batra +3 more
openaire +2 more sources