HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]
, 2014 Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D +4 more
core +1 more source
Last Year\u27s Virus, This Year\u27s Cancer Treatment [PDF]
, 2018 For hundreds of years, cancer has stumped medical professionals across the world as a cure evaded them. Now, a new approach to battling cancer has entered the arena: viruses.
Collins, Olivia
core +1 more source
Sorting Out Pandora’s Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma [PDF]
, 2014 Oncolytic viral therapies have recently found their way into clinical application for hepatocellular carcinoma (HCC), a disease with limited treatment options and poor prognosis. Adding to the many intrinsic challenges of in vivo oncolytic viral therapy,
Jennifer Altomonte, Oliver Ebert
core +3 more sources
Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity [PDF]
, 2020 Su-Nam Jeong, So Young Yoo
openalex +1 more source
Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications
MedComm, Volume 7, Issue 2, February 2026.The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin +12 more
wiley +1 more source
Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses
Frontiers in Oncology, 2017 The rapid growth of tumors depends upon elevated levels of dNTPs, and while dNTP concentrations are tightly regulated in normal cells, this control is often lost in transformed cells.
Chad R. Irwin +5 more
doaj +1 more source
More Than Microbiome and Medicine
Microbiota Medicine Research, EarlyView.
Faming Zhang +2 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies [PDF]
, 2016 Encouraging results from recent clinical trials are revitalizing the field of oncolytic virotherapies. Human adenovirus type 5 (HAdV-C5/Ad5) is a common vector for its ease of manipulation, high production titers and capacity to transduce multiple cell ...
Chester, John +4 more
core +1 more source