Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis
, 2018 Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects.
Eladdadi, Amina +4 more
core +1 more source
The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
core +2 more sources
Neoadjuvant therapy in skin cancer: current evidence and future perspectives
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary The development of immune checkpoint inhibitors and targeted therapies has fundamentally changed the treatment of cutaneous malignancies, especially in squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The latest neoadjuvant approaches have shown promising results in locally advanced stages.
Lea Daniello +2 more
wiley +1 more source
Biologics: Targets & Therapy, 2018 Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells.
Lundstrom K
doaj
Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination
Nature Communications, 2021 Viruses expressing tumour antigens can prime and boost anti-tumour immunity but the efficiency of this approach depends on the capacity of the virus to infect the host.
D. G. Roy +14 more
doaj +1 more source
Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta [PDF]
, 2014 Background: Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in Third World countries.
Hu, Pan +6 more
core +2 more sources
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, EarlyView.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Attenuated Semliki Forest virus for cancer treatment in dogs : safety assessment in two laboratory Beagles [PDF]
, 2015 Background: Dogs suffer from spontaneous tumors which may be amenable to therapies developed for human cancer patients, and dogs may serve as large-animal cancer models.
Anttila, Marjukka O. +7 more
core +1 more source
Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li +13 more
wiley +1 more source
Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients. [PDF]
, 2019 Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1].
Bouvet, Michael +5 more
core +1 more source