Results 81 to 90 of about 15,940 (198)
Journal of Applied Health Sciences, 2018 Malignant tumors are the most common cause of mortality in humans. Accumulation of mutation in cells causes uncontrolled cell division as well as prevention of their programmed cell death, leading to neoplastic changes. Tumor mass which avoids the immune response of the host, grows and spreads. Modern approach to malignant tumor therapy, which is still
Poljak, Ines, Korać, Petra
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Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
MedComm, Volume 7, Issue 3, March 2026.Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
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Oncolytic vaccinia virus and cancer immunotherapy
Frontiers in ImmunologyOncolytic virotherapy (OVT) is a promising form of cancer treatment that uses genetically engineered viruses to replicate within cancer cells and trigger anti-tumor immune response.
Lihua Xu +5 more
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Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors
OncoImmunology, 2018 Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic
Jonathan G. Pol +14 more
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Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses
Frontiers in Oncology, 2014 Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures.
Nicole E. Forbes +5 more
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MedComm, Volume 7, Issue 3, March 2026.This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng +8 more
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Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase
Molecular Therapy: Oncolytics, 2017 Oncolytic viruses are currently established as a novel type of immunotherapy. The challenge is to safely target oncolytic viruses to tumors. Previously, we have generated influenza A viruses (IAVs) containing deletions in the viral interferon antagonist.
Irina Kuznetsova +10 more
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More Than Microbiome and Medicine
Microbiota Medicine Research, EarlyView.
Faming Zhang +2 more
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Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 3, March 2026.This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang +10 more
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Oncolytic viruses as therapeutic agents
Annals of Medicine, 2001 The concept of using viruses as oncolytic agents has a long history. However, relatively new developments are the use of these viruses as gene delivery vehicles and the restriction of viral replication and lysis to tumour cells. The latter is attempted by the use of tumour-specific promoters, which transcriptionally target viral genes involved in ...
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