Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis [PDF]
Frontiers in Immunology, 2023 Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA.
Liang Han +15 more
doaj +4 more sources
Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity [PDF]
Frontiers in ImmunologyBackgroundOncostatin M (OSM) is a cytokine that mediates inflammatory processes and is overexpressed in skin lesions of atopic dermatitis (AD). By amplifying neural responses to chemicals such as histamine, OSM increases sensitivity to pruritus. However,
Chie Ishikawa +13 more
doaj +4 more sources
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling [PDF]
Stem Cell Research & Therapy, 2022 Background Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption.
Jie Zhou +7 more
doaj +2 more sources
Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells [PDF]
Communications BiologyThe molecular and functional changes in endothelial cells during disease progression such as cancer have been noted but the mechanism of their activation is still under-studied.
Hieu-Huy Nguyen-Tran +2 more
doaj +2 more sources
Drug Repurposing to Inhibit Oncostatin M in Crohn’s Disease [PDF]
MoleculesCrohn’s disease is an inflammatory bowel disease (IBD) that currently lacks satisfactory treatment options. Therefore, new targets for new drugs are urgently needed to combat this disease.
Faranak Bahramimehr +11 more
doaj +2 more sources
Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair [PDF]
European Cells & Materials, 2013 Mediators in the synovial fluid are thought to play a major role in osteoarthritic cartilage turnover. The purpose of the current study was to investigate the role of oncostatin M (OSM) in osteoarthritis (OA) by evaluating the presence of the cytokine ...
M Beekhuizen +6 more
doaj +5 more sources
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]
, 2015 Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara +6 more
core +10 more sources
Role and prognostic value of oncostatin M and its receptor OSMR in acute myeloid leukemia, myeloproliferative neoplasms and non-hematological malignancies [PDF]
Frontiers in OncologyThe oncostatin M receptor (OSMR) has recently emerged as an adverse prognostic factor in acute myeloid leukemia (AML) and several non-hematological malignancies.
Jean-Pierre Lévesque +3 more
doaj +2 more sources
Oncostatin M Is Related to Polycystic Ovary Syndrome-Case Control Study [PDF]
BiomedicinesBackground: Oncostatin M, a novel adipokine, plays a role in oogenesis, lipogenesis, and inflammation and may contribute to polycystic ovary syndrome pathogenesis and related metabolic problems.
Figen Efe Camili +6 more
doaj +2 more sources
Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease [PDF]
American Heart Journal Plus, 2023 Objective: Oncostatin M (OSM) is an inflammatory cytokine belonging to the interleukin-6 family member, which plays an important role in various cardiovascular diseases.
Shohei Ikeda +7 more
doaj +2 more sources