Results 81 to 90 of about 21,326 (236)

Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration [PDF]

, 2016
© 2016 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed PressRecent pre-clinical and clinical studies have suggested that endogenous cardiospheres (eCS) are potentially safe and effective for cardiac regeneration ...
Beltrami, Bondue, Cai, Chen, Cohen, Efe, Fazel, Gessert, Guatimosim, Hoon, Ishigami, Karmazinova, Kattman, Kawamoto, Kubin, Kucia, Kuzmenkin, Kwon, Lee, Lee, Li, Liao, Lin, Lozano, Menasche, Messina, Mishra, Murray, Naviaux, Ng, Oyama, Pacher, Pointon, Qyang, Sanganalmath, Simpson, Siu, Smith, Takahashi, Torella, Tse, Wang, Weil, Wu, Zhou   +44 more
core   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Hypoxia-inducible factor 1α is up-regulated by oncostatin M and participates in oncostatin M signaling # [PDF]

Hepatology, 2009
Abstract The interleukin-6–type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well as via activation of mitogen-activated protein kinases and is known to critically regulate processes such as liver development and regeneration, hematopoiesis, and angiogenesis ...
Stefan, Vollmer, Valérie, Kappler, Jakub, Kaczor, Daniela, Flügel, Catherine, Rolvering, Nobuyuki, Kato, Thomas, Kietzmann, Iris, Behrmann, Claude, Haan   +8 more
openaire   +2 more sources

Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Nature Communications, 2019
Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac ...
Hajime Abe, Norihiko Takeda, Takayuki Isagawa, Hiroaki Semba, Satoshi Nishimura, Masaki Suimye Morioka, Yu Nakagama, Tatsuyuki Sato, Katsura Soma, Katsuhiro Koyama, Masaki Wake, Manami Katoh, Masataka Asagiri, Michael L. Neugent, Jung-whan Kim, Christian Stockmann, Tomo Yonezawa, Ryo Inuzuka, Yasushi Hirota, Koji Maemura, Takeshi Yamashita, Kinya Otsu, Ichiro Manabe, Ryozo Nagai, Issei Komuro   +24 more
doaj   +1 more source

Human cytomegalovirus immediate-early 1 protein rewires upstream STAT3 to downstream STAT1 signaling switching an IL6-type to an IFNγ-like response [PDF]

, 2016
MN and CP were supported by the Wellcome Trust (www.wellcome.ac.uk) Institutional Strategic Support Fund and CP was supported by the Deutsche Forschungsgemeinschaft (PA 815/2-1; www.dfg.de).The human cytomegalovirus (hCMV) major immediate-early 1 protein
Thomas Harwardt, Simone Lukas, Marion Zenger, Tobias Reitberger, Daniela Danzer, Theresa Übner, Diane C. Munday, Michael Nevels, Christina Paulus, Robert F. Kalejta, S Abroun, JJ O'Shea, D Guschin, SJ Rodig, NC Reich, H Yu, F Schaper, B Carow, Y Yin, JR Teijaro, N Au-Yeung, I Najjar, B Saha, G Regis, AP Costa-Pereira, HH Ho, A Stephanou, P Kumari, RE Randall, C Richardson, T Knoblach, VH Wood, R Renne, M Chatterjee-Kishore, JE McLaren, WJ Liu, WY Chen, J McLaren, SV Kuchipudi, JM Reitsma, CA King, D Daigle, T Du, ER Hill, S Koganti, E Slinger, M Boeckh, P Griffiths, Y Cohen, E Mocarski, C Paulus, M Scherer, L Amsler, M Trilling, VT Le-Trilling, EE Marshall, JH Ahn, JM Gawn, RF Greaves, ES Mocarski, L Torres, C Paulus, S Krauss, YH Huh, M Scherer, S Müller, ML Spengler, M Nevels, J Reinhardt, RL Lafemina, GW Wilkinson, K Mücke, YE Kim, J Jaworska, JL Meier, A Kaptein, J Renneson, RT Taylor, EP Browne, G Chan, M Mezger, DN Streblow, J Dumortier, MC Cheeran, P Caposio, SP Gravel, K Lee, K Koh, E Beurel, M Shu, DJ Dauer, M Snyder, Q Lepiller, Y Xu, RD Everett, Y Lu, GP Hayhurst, AD Yurochko, MJ Margolis, Q Tang, M Reeves, JH Ahn, M Nevels, E Zalckvar, B Raghavan, B Strobl, PC Heinrich, N Stahl, U Hemmann, C Gerhartz, Y Qing, D Kamimura, HA Bluyssen, GR Gariano, T Li, F Dag, JK Holzki, MB Reeves, C Söderberg-Naucler, XF Liu, CA Biron, M Trilling, D Hargett, E Poole, MS Smith, E Poole, RD Everett, BK Tischer, H Zhu, S Hambleton, FL Graham, C Sinzger, M Umashankar, UK Laemmli, A Colson, K Mahboubi, RP Donnelly, BJ Grube, RR Schumann, MK Steiner, T Mohri, JH Lee, G Hoermann, SK Singh, SA Robertson, A Gazel, A Ito, A Okaya, L Zhang, A Dreuw, S Porter, H Wang, FM Rogerson, RI Nurieva, M Ciofani, Y Ikeda, F Blanchard, SL Turner, E Larrea, SR Walker, BJ Van Lenten, S Sawa, P Chakrabarty, MA Nowell, EJ Kim, JA van Roon, TG Boulton, CT Sherman, OA Timofeeva, Z Ni, BJ Jenkins, PA Croonquist, H Zhu, M Saito, JE Jung, F Xiao, D Zhang, D Maritano, M Ichiba, KN Khan, T Wuestefeld, TK Sengupta, M Tomida, AF Voronova, L Williams, O Kim, C Bovolenta, M Zemskova, F Zhang, JX Zhang   +189 more
core   +3 more sources

Safety and efficacy of nemolizumab for atopic dermatitis up to 2 years in open‐label extension study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This study evaluated long‐term safety and efficacy in patients with moderate‐to‐severe atopic dermatitis. Patients with and without previous nemolizumab experience received nemolizumab 30 mg Q4W plus TCS/TCI. Nemolizumab was well‐tolerated through 104 weeks with clinically meaningful improvements in disease signs and symptoms.
Matthias Augustin, Marie Tauber, Robert Sidbury, Jonathan I. Silverberg, Kim A. Papp, Diamant Thaçi, Marjolein S. De Bruin‐Weller, Adam Reich, Ketty Peris, Kirk Barber, Ryszard Galus, Andrzej Kaszuba, Matthew Zirwas, Walter K. Nahm, Gretel Trullenque, Laura Maintz, Sady Alpizar, Sang Wook Son, Vivian Laquer, Linda Stein Gold, Soo Yeon Cheong, Anna Ryzhkova, Agnes Drahos, Liliana Ulianov, Christophe Piketty   +24 more
wiley   +1 more source

Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes [PDF]

, 2013
CONTEXT: Adipose tissue is a highly active endocrine organ that secretes many factors that affect other tissues and whole-body metabolism. Adipocytes are responsive to several glycoprotein 130 (gp130) cytokines, some of which have been targeted as ...
Albasanz-Puig, Alessi, Anthony W. Ferrante, Balhoff, Blüher, Blüher, Brown, Carrie M. Elks, Celik, Crowe, David Sanchez-Infantes, Demyanets, Di Gregorio, Eric Ravussin, Ettinger, Fasnacht, Febbraio, Fried, Ghosh, Gloaguen, Hansen, Heinrich, Henkel, Hui, Jacqueline M. Stephens, Jeffrey M. Gimble, Kamiya, Kern, Komori, Lambert, Lehr, López, Miyaoka, Mohamed-Ali, Mosley, Nakamura, Natal, Okaya, Ouchi, Pradeep, Rega, Robert V. Considine, Ron F. Morrison, Rose, Rose, Rotter, Sleeman, Slevin, Song, Stephens, Suda, Tamura, Tenney, Ursula A. White, Virtue, Wahl, Wallace, Wallenius, Weisberg, White, White, Zarling, Zvonic, Zvonic   +63 more
core   +2 more sources

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Drug Design, Development and Therapy, 2015
Michael R Preusch,1,2 Nicholas Ieronimakis,1 Errol S Wijelath,3 Sara Cabbage,1 Jerry Ricks,1 Florian Bea,2 Morayma Reyes,1 Joanne van Ryn,4 Michael E Rosenfeld1,5 1Department of Pathology, University of Washington, Seattle, WA, USA; 2Department of ...
Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME   +8 more
doaj  

The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells

Cells, 2019
Homeobox protein B13 (HOXB13), a transcription factor, is related to methylmercury toxicity; however, the downstream factors involved in enhancing methylmercury toxicity remain unknown.
Takashi Toyama, Sidi Xu, Ryo Nakano, Takashi Hasegawa, Naoki Endo, Tsutomu Takahashi, Jin-Yong Lee, Akira Naganuma, Gi-Wook Hwang   +8 more
doaj   +1 more source