Results 41 to 50 of about 20,326,064 (257)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

392 Targeting One-Carbon Metabolism in Brain Cancer

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis.
Emma Rowland, Nagi G. Ayad
doaj   +1 more source

Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function

Physiological Reports, 2020
Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available.
Brandon J. Eudy, Caitlin E. McDermott, Xiuli Liu, Robin P. daSilva   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

One-carbon metabolism and ionizing radiation: a multifaceted interaction

Biomolecular Concepts, 2017
Ionizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes ...
Miousse Isabelle R., Tobacyk Julia, Melnyk Stepan, James S. Jill, Cheema Amrita K., Boerma Marjan, Hauer-Jensen Martin, Koturbash Igor   +7 more
doaj   +1 more source

Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study

Brain and Behavior, 2020
Background Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to ...
Rachael M. Taylor, Roger Smith, Clare E. Collins, David Mossman, Michelle W. Wong‐Brown, Eng‐Cheng Chan, Tiffany‐Jane Evans, John R. Attia, Nick Buckley, Karen Drysdale, Tenele Smith, Trent Butler, Alexis J. Hure   +12 more
doaj   +1 more source

Glioma cells require one-carbon metabolism to survive glutamine starvation

Acta Neuropathologica Communications, 2021
Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and ...
Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura   +18 more
doaj   +1 more source

One-Carbon Metabolism: An Unsung Hero for Healthy Aging

, 2016
One-carbon metabolism ultimately delivers one-carbon moiety (methyl group) to many biologic reactions, including nucleotide synthesis and biological methylation, that are needed to synthesize essential components of cells and tissues and to maintain body
Suh, Eunkyung, Choi, Sang Woon, Simonetta Friso, FRISO, Simonetta, Sang-Woon Choi, Eunkyung Suh   +5 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Subcellular one carbon metabolism in cancer, aging and epigenetics

Frontiers in Epigenetics and Epigenomics
The crosstalk between metabolism and epigenetics is an emerging field that is gaining importance in different areas such as cancer and aging, where changes in metabolism significantly impacts the cellular epigenome, in turn dictating changes in chromatin
Tiziano Bernasocchi, Tiziano Bernasocchi, Raul Mostoslavsky, Raul Mostoslavsky   +3 more
doaj   +1 more source