Results 21 to 30 of about 20,326,064 (257)

Mitochondrial One-Carbon Metabolism and Alzheimer's Disease. [PDF]

Mitochondrial one-carbon metabolism provides carbon units to several pathways, including nucleic acid synthesis, mitochondrial metabolism, amino acid metabolism, and methylation reactions.
Yizhou Yu, L. Miguel Martins, Martins, L. Miguel, Yu, Yizhou   +3 more
core   +4 more sources

Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one‐carbon metabolism

Physiological Reports, 2020
Maternal obesity during pregnancy can adversely affect adult offspring vascular endothelial function. This study examined whether maternal exercise during pregnancy and lactation mitigates the adverse effects of maternal obesity on offspring vascular ...
Nicha P. Boonpattrawong, Saeid Golbidi, Daven C. Tai, Rika E. Aleliunas, Pascal Bernatchez, Joshua W. Miller, Ismail Laher, Angela M. Devlin   +7 more
doaj   +1 more source

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Cancer & Metabolism, 2017
Background Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes.
Minhye Shin, Jessica Momb, Dean R. Appling   +2 more
doaj   +1 more source

One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue

, 2022
Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Karel Kalecký, Paula Ashcraft, Teodoro Bottiglieri   +2 more
core   +1 more source

One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study

Journal of Affective Disorders Reports, 2021
Background: While considered less severe than major depressive disorder (MDD), chronic depression has a devastating effect on people's lives. Metabolic alterations related to chronicity are still widely unknown.
Karoliina Kurkinen, Olli Kärkkäinen, Soili M. Lehto, Ilona Luoma, Siiri-Liisi Kraav, Anni I. Nieminen, Petri Kivimäki, Sebastian Therman, Tommi Tolmunen   +8 more
doaj   +1 more source

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism [PDF]

, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Millington, Christopher L, Bruemmer, Kevin J, Pontel, Lucas B, Ge, Eva J, Toh, Joel DW, Esteller, Manel, Ingolia, Nicholas T, Dingler, Felix A, Pulos-Holmes, Mia C, Nomura, Daniel K, Ward, Carl C, Garcia-Prieto, Carlos A, Patel, Ketan J, Pham, Vanha N, Chang, Christopher J, Tenney, Logan   +15 more
core   +1 more source

Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond [PDF]

, 2022
Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with the methionine cycle to complete the one carbon pathway.
Nguyen, Steven T, Leonard, Jack T., Seabrook, Laurence J, Leonard, Jack T, Lauren V. Albrecht, Carolina N. Franco, Albrecht, Lauren V, Steven T. Nguyen, Jack T. Leonard, Franco, Carolina N., Albrecht, Lauren V., Seabrook, Laurence J., Nguyen, Steven T., Laurence J. Seabrook, Franco, Carolina N   +14 more
core   +1 more source

Choline and one-carbon metabolite response to egg, beef and fish among healthy young men: A short-term randomized clinical study

Clinical Nutrition Experimental, 2016
Background: Homeostatic mechanisms that regulate long-term circulating concentrations of choline and one-carbon metabolites can obscure the relationship between diet and nutritional response.
Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Jian Yan, Marie A. Caudill   +5 more
doaj   +1 more source

One-carbon metabolism metabolite levels at T0 and T1 (n = 67).

, 2019
One-carbon metabolism metabolite levels at T0 and T1 (n = 67).
Bertrand D. van Zelst (7392497), Robert de Jonge (4926013), Marry M. van den Heuvel-Eibrink (7391279), Sandra G. Heil (4044344), Wim J. E. Tissing (7392494), Natanja Oosterom (5492705), Marta Fiocco (387043), Desiree E. C. Smith (7392491), Rob Pieters (294079)   +8 more
core   +1 more source

Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells. [PDF]

, 2010
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount of information concerning their metabolic potential.
Götz Andreas, Götz, Andreas, Eylert, Eva, Eylert Eva, Werner Goebel, Goebel, Werner, Eva Eylert, Eisenreich, Wolfgang, Goetz, Andreas, Andreas Götz, Wolfgang Eisenreich, Eisenreich Wolfgang, Goebel Werner   +12 more
core   +2 more sources