Results 11 to 20 of about 20,326,064 (257)

Targeting one‐carbon metabolism for cancer immunotherapy

Clinical and Translational Medicine
Background One‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to fuel metabolic pathways, including nucleotide metabolism, amino acid metabolism, cellular
Xinxin Ren, Xiang Wang, Guowan Zheng, Shanshan Wang, Qiyue Wang, Mengnan Yuan, Tong Xu, Jiajie Xu, Ping Huang, Minghua Ge   +9 more
doaj   +2 more sources

The Antioxidant Role of One-Carbon Metabolism on Stroke

Antioxidants, 2020
One-carbon (1C) metabolism is a metabolic network that is centered on folate, a B vitamin; it integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics.
Kassidy Burgess, Calli Bennett, Hannah Mosnier, Neha Kwatra, Forrest Bethel, Nafisa M. Jadavji   +5 more
doaj   +2 more sources

Genetic markers of One-Carbon Metabolism Disorders in Schizophrenial [PDF]

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
The paper presents the results of the literature review and the authors’ own studies of the association of several several single-nucleotide genetic polymorphisms (SNP), which affect one-carbon metabolism, with a risk of schizophrenia and the severity of
T. V. Zhilyaeva, A. S. Piatoikina, A. S. Blagonravova, G. E. Mazo   +3 more
doaj   +2 more sources

Targeted Proteomics for Monitoring One-Carbon Metabolism in Liver Diseases

Metabolites, 2022
Liver diseases cause approximately 2 million deaths per year worldwide and had an increasing incidence during the last decade. Risk factors for liver diseases include alcohol consumption, obesity, diabetes, the intake of hepatotoxic substances like ...
Laura Guerrero, Alberto Paradela, Fernando J. Corrales   +2 more
doaj   +2 more sources

Notes from the 2022 Folate, Vitamin B12, and One-Carbon Metabolism Conference

, 2023
Here, we present notes from the Folate, Vitamin B12, and One-Carbon Metabolism Conference organized by The Federation of American Societies for Experimental Biology (FASEB), held in Asheville, North Carolina, USA, 14–19 August 2022. We aim to share
Naama Kanarek, Adam G. Maynard, Boryana Petrova   +2 more
core   +1 more source

Interactions between Radiation and One-Carbon Metabolism

, 2022
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance.
Daniel R. Wahl, Navyateja Korimerla
core   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Elke K. Markert, Alexei Vazquez, Elke Markert, Zoltan Oltvai, Zoltan N. Oltvai   +4 more
core   +3 more sources

Preprint: Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

, 2023
Previous virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect S.
Wall, E., Brown, J.S., Ercoli, G., Guerra-Assunção, J.A., Gordon, S.B., Ramos-Sevillano, E., Heyderman, R., Betts, M., Fernandes, V.E., Ferreira, D.M., Partridge, F.   +10 more
core   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
Alice C Newman, Maddocks, Oliver D.K., Newman, Alice C., Oliver D K Maddocks   +3 more
core   +1 more source

COVID-19 and One-Carbon Metabolism

, 2022
Dysregulation of one-carbon metabolism affects a wide range of biological processes and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer.
Joanna Perła-Kaján, Hieronim Jakubowski   +1 more
core   +1 more source