Results 21 to 30 of about 20,326,114 (289)

One-carbon metabolism in children with marasmus and kwashiorkor [PDF]

eBioMedicine, 2022
Kwashiorkor is a childhood syndrome of edematous malnutrition. Its precise nutritional precipitants remain uncertain despite nine decades of study. Remarkably, kwashiorkor's disturbances resemble the effects of experimental diets that are deficient in one-carbon nutrients. This similarity suggests that kwashiorkor may represent a nutritionally mediated
Thaddaeus May, Bethany de la Haye, Gabrielle Nord, Kevin Klatt, Kevin Stephenson, Sara Adams, Lucy Bollinger, Neil Hanchard, Erland Arning, Teodoro Bottiglieri, Kenneth Maleta, Mark Manary, Farook Jahoor   +12 more
openaire   +4 more sources

Notes from the 2022 Folate, Vitamin B12, and One-Carbon Metabolism Conference

, 2023
Here, we present notes from the Folate, Vitamin B12, and One-Carbon Metabolism Conference organized by The Federation of American Societies for Experimental Biology (FASEB), held in Asheville, North Carolina, USA, 14–19 August 2022. We aim to share
Naama Kanarek, Adam G. Maynard, Boryana Petrova   +2 more
core   +1 more source

Modeling cellular compartmentation in one‐carbon metabolism [PDF]

WIREs Systems Biology and Medicine, 2013
AbstractFolate‐mediated one‐carbon metabolism (FOCM) is associated with risk for numerous pathological states including birth defects, cancers, and chronic diseases. Although the enzymes that constitute the biological pathways have been well described and their interdependency through the shared use of folate cofactors appreciated, the biological ...
Scotti M., Stella L., Shearer E. J., Stover P. J.   +3 more
openaire   +2 more sources

One-carbon metabolism and depression [PDF]

British Journal of Psychiatry, 2008
Kim et al concluded that lower levels of folate and vitamin B12 and raised homocysteine may be risk factors for late-life depression.[1][1] We propose to include polyunsaturated fatty acids (PUFAs) in future studies that will test the potential role of one-carbon metabolism in the aetiology ...
Assles, J., Pouwer, F.
openaire   +3 more sources

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Elke K. Markert, Alexei Vazquez, Elke Markert, Zoltan Oltvai, Zoltan N. Oltvai   +4 more
core   +3 more sources

Preprint: Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

, 2023
Previous virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect S.
Wall, E., Brown, J.S., Ercoli, G., Guerra-Assunção, J.A., Gordon, S.B., Ramos-Sevillano, E., Heyderman, R., Betts, M., Fernandes, V.E., Ferreira, D.M., Partridge, F.   +10 more
core   +1 more source

The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

Frontiers in Immunology, 2023
ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases.
Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason   +9 more
doaj   +1 more source

One carbon metabolism in human lung cancer [PDF]

Translational Lung Cancer Research, 2021
Lung cancer remains the major cause of cancer related death worldwide. The discovery of targeted therapies against activating mutations in genes like EGFR considerably improved the prognosis for a subgroup of patients but still leaves a large part without a targeted therapy.
Yao, Sha, Peng, Luogen, Elakad, Omar, Küffer, Stefan, Hinterthaner, Marc, Danner, Bernhard C., Hammerstein-Equord, Alexander von, Ströbel, Philipp, Bohnenberger, Hanibal   +8 more
openaire   +3 more sources

One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study

Journal of Affective Disorders Reports, 2021
Background: While considered less severe than major depressive disorder (MDD), chronic depression has a devastating effect on people's lives. Metabolic alterations related to chronicity are still widely unknown.
Karoliina Kurkinen, Olli Kärkkäinen, Soili M. Lehto, Ilona Luoma, Siiri-Liisi Kraav, Anni I. Nieminen, Petri Kivimäki, Sebastian Therman, Tommi Tolmunen   +8 more
doaj   +1 more source

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Cancer & Metabolism, 2017
Background Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes.
Minhye Shin, Jessica Momb, Dean R. Appling   +2 more
doaj   +1 more source