Results 31 to 40 of about 20,326,114 (289)

Bringing carbon to life via one-carbon metabolism. [PDF]

Trends Biotechnol
One-carbon (C1) compounds found in greenhouse gases and industrial waste streams are underutilized carbon and energy sources. While various biological and chemical means exist for converting C1 substrates into multicarbon products, major challenges of C1 conversion lie in creating net value. Here, we review metabolic strategies to utilize carbon across
O'Keeffe S, Garcia L, Chen Y, Law RC, Liu C, Park JO.   +5 more
europepmc   +3 more sources

One-carbon metabolism in psychiatric illness [PDF]

Nutrition Research Reviews, 2006
The cost of psychiatric illness to the UK economy was recently estimated at £77 billion annually. Despite years of research no firm aetiological explanation exists, and with no physiological or biochemical markers diagnosis is made entirely on a behavioural basis. All current pharmacological therapies are associated with serious long-term side effects.
openaire   +2 more sources

IDH3α regulates one-carbon metabolism in glioblastoma [PDF]

Science Advances, 2019
IDH3α promotes glioblastoma progression and links mitochondrial metabolism to cSHMT-controlled one-carbon metabolism.
Jasmine L. May, Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, Andrea E. Calvert, Andrew Lee, Navdeep S. Chandel, Ramana V. Davuluri, Craig M. Horbinski, Jason W. Locasale, Alexander H. Stegh   +13 more
openaire   +2 more sources

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Cells, 2022
One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key modules of this network that regulate purine and thymidine synthesis ...
Eirini Lionaki, Christina Ploumi, Nektarios Tavernarakis   +2 more
doaj   +1 more source

One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue

, 2022
Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Karel Kalecký, Paula Ashcraft, Teodoro Bottiglieri   +2 more
core   +1 more source

Choline and one-carbon metabolite response to egg, beef and fish among healthy young men: A short-term randomized clinical study

Clinical Nutrition Experimental, 2016
Background: Homeostatic mechanisms that regulate long-term circulating concentrations of choline and one-carbon metabolites can obscure the relationship between diet and nutritional response.
Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Jian Yan, Marie A. Caudill   +5 more
doaj   +1 more source

Abnormalities in one-carbon metabolism in young patients with psychosis

Frontiers in Psychiatry, 2023
IntroductionFolates, the main actors in one-carbon (C1) metabolism, are involved in synthesising monoamines and maintaining genomic stability. Previous studies support the association between C1 metabolism and schizophrenia.
Ariel Frajerman, Ariel Frajerman, Ariel Frajerman, Marie Urban, Fabrice Rivollier, Fabrice Rivollier, Marion Plaze, Boris Chaumette, Boris Chaumette, Boris Chaumette, Marie-Odile Krebs, Marie-Odile Krebs, Linda Scoriels, Linda Scoriels   +13 more
doaj   +1 more source

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism [PDF]

, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Millington, Christopher L, Bruemmer, Kevin J, Pontel, Lucas B, Ge, Eva J, Toh, Joel DW, Esteller, Manel, Ingolia, Nicholas T, Dingler, Felix A, Pulos-Holmes, Mia C, Nomura, Daniel K, Ward, Carl C, Garcia-Prieto, Carlos A, Patel, Ketan J, Pham, Vanha N, Chang, Christopher J, Tenney, Logan   +15 more
core   +1 more source

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

eLife, 2016
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration.
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha   +14 more
doaj   +1 more source

One-carbon metabolism metabolite levels at T0 and T1 (n = 67).

, 2019
One-carbon metabolism metabolite levels at T0 and T1 (n = 67).
Bertrand D. van Zelst (7392497), Robert de Jonge (4926013), Marry M. van den Heuvel-Eibrink (7391279), Sandra G. Heil (4044344), Wim J. E. Tissing (7392494), Natanja Oosterom (5492705), Marta Fiocco (387043), Desiree E. C. Smith (7392491), Rob Pieters (294079)   +8 more
core   +1 more source