Results 51 to 60 of about 20,326,114 (289)
392 Targeting One-Carbon Metabolism in Brain Cancer
Journal of Clinical and Translational ScienceOBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis.
Emma Rowland, Nagi G. Ayad
doaj +1 more source
One-carbon metabolism and ionizing radiation: a multifaceted interaction
Biomolecular Concepts, 2017 Ionizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes ...
Miousse Isabelle R. +7 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus [PDF]
Diabetes & Metabolism JournalDiabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance.
Jie Zhu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Subcellular one carbon metabolism in cancer, aging and epigenetics
Frontiers in Epigenetics and EpigenomicsThe crosstalk between metabolism and epigenetics is an emerging field that is gaining importance in different areas such as cancer and aging, where changes in metabolism significantly impacts the cellular epigenome, in turn dictating changes in chromatin
Tiziano Bernasocchi +3 more
doaj +1 more source
Chromium induced neurotoxicity by altering metabolism in zebrafish larvae
Ecotoxicology and Environmental Safety, 2021 Background: Recently, both trivalent chromium Cr (III) and hexavalent chromium Cr (VI) have been reported to produce neurotoxicity. However, the underlying mechanisms of the neurotoxicity caused by different chemical valence of chromium remain unclear ...
Yawen Xu +6 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Correction to: Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico [PDF]
, 2019 Correction to: "Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in ...
Gamble, Mary V. +8 more
core +1 more source
Metabolomics analysis reveals dysregulation in one carbon metabolism in Friedreich Ataxia [PDF]
, 2022 Friedreich Ataxia (FA) is a rare and often fatal autosomal recessive disease in which a mitochondrial protein, frataxin (FXN), is severely reduced in all tissues. With loss of FXN, mitochondrial metabolism is severely disrupted.
Payne, R. Mark +5 more
core +1 more source