Results 161 to 170 of about 22,170 (231)

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respond in skeletal muscle to support this remarkable resilience.
Audrey Bergouignan, John Noone, Charlotte Brun, Laura Cussonneau, Alexandre Geffroy, Cecile Coudy‐Gandilhon, Isabelle Chery, Alina Lynn Evans, Jon Martin Arnemo, Jonas Kindberg, Guillemette Gauquelin‐Koch, Donal O'Gorman, Etienne Lefai, Fabrice Bertile   +13 more
wiley   +1 more source

The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

Nature Communications
Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a ...
Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige K. Boneski, Hiromi Sesaki, Ruteja A. Barve, John A. Collins, Makarand V. Risbud   +10 more
doaj   +1 more source

Optic atrophy 1 (OPA1) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Frequency and Hearing Loss Phenotypes of <i>OPA1</i> Variants in a Cohort of 18,475 Patients with Hearing Impairment. [PDF]

Genes (Basel)
Kawakita M, Moteki H, Nishio SY, Kobayashi Y, Adachi M, Okano T, Yamazaki H, Nakayama J, Ohira S, Ishino T, Takumi Y, Usami SI.   +11 more
europepmc   +1 more source

OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration. [PDF]

JACC Basic Transl Sci
Ronfini M, Prando V, Di Mauro V, Dokshokova L, Lazzeri E, Costantini I, Alàn L, Riviere EA, Incensi A, Olianti C, La Morgia C, Liguori R, Sacconi L, Donadio V, Scorrano L, Carelli V, Mongillo M, Zaglia T.   +17 more
europepmc   +1 more source

OPA1 as a Cancer Target: Molecular Mechanisms, Structural Insights, and Strategies for Drug Development. [PDF]

Antioxidants (Basel)
Curcio A, Ganino L, Valentino I, Gentile M, Alcaro S, Rocca R, Artese A, Amodio N.   +7 more
europepmc   +1 more source

Expanding the <i>AFG3L2</i> Spectrum: A Link to Axonal Neuropathy. [PDF]

Neurol Genet
Rocco A, Laurini C, Falzone YM, Calzavara S, Del Carro U, Previtali SC, Maltecca F.   +6 more
europepmc   +1 more source

Mitochondrial acetyl-CoA reprogramming by the SIRT3-ACSS2-OPA1 axis confers resistance to ferroptosis in Parkinson's disease. [PDF]

Redox Biol
Ding XS, Wang B, Han Z, Feng CX, Li YN, Wang YF, Guru JC, Cao J, Zhang RL, Wang XL, Yang Q, Qu Y, Gao L.   +12 more
europepmc   +1 more source

Role of Mammalian Prohibitins in the Regulation of Apoptosis [PDF]

, 2010
Dargazanli, Sascha
core  

Caffeine Sodium Benzoate-Induced Macrophage M1 Polarization Promotes Endothelial Progenitor Cell Dysfunction by Inducing Mitochondrial Dysfunction Via Targeting let-7a-5p/OPA1 Axis. [PDF]

Appl Biochem Biotechnol
Yu T, Yuan Y, Suo F, Guo R, Li W, Wang X, Suriguga, Zhao H, Tian L, Yang H, Yan Q, Feng L.   +11 more
europepmc   +1 more source