Results 111 to 120 of about 2,077,918 (304)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Wasit Journal for Pure SciencesData mining categorization is crucial for predicting outcomes. Naive Bayes Classification (NBC) is a prominent approach used in data mining for classification purposes. It has the ability to anticipate outcomes and is generally more efficient than other
Mohammed Hasan, Asmaa ali
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
CORE—China Open Resource for Education
, 2005 China Open Resources for Education (CORE) is a consortium of universities that began with 26 IET Educational Foundation member universities and 44 China Radio and TV Universities.
CORE—China Open Resource for Education
core
Transformative Sustainability-Oriented Open Education
, 2020 How can open education play a role in making academia more responsive and responsible in addressing ill-defined and ambiguous, but ever so urgent, sustainable development challenges? In this chapter, a case study from the field of sustainable development
Algers, Anne, +2 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Teacher Education Through Open and Distance Learning
, 2003 This item is not available to download but is available from Commonwealth of Learning's Information Resource Centre (IRC) library or to purchase from Commonwealth of Learning (see attached file for details).How can open and distance learning and ...
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Journal of Research, Innovation, and Strategies for EducationLearning Management Systems (LMS) have become vital tools in open and distance learning (ODL), playing a central role in supporting teaching and learning.
Nawastheen Fareed Mohamed +4 more
doaj +1 more source