Results 111 to 120 of about 1,704,562 (320)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Reaching out with OER: the new role of public-facing open scholar [PDF]

, 2012
Open educational resources (OER) and, more recently, open educational practices (OEP) have been widely promoted as a means of increasing openness in higher education (HE). Thus far, such openness has been limited by OER provision typically being supplier-
Coughlan, Tony, Perryman, Leigh-Anne
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Guidelines for structuring learning and teaching opportunities relevant to educators’ open educational resource (OER) engagement [PDF]

, 2015
Six guidelines for structuring learning and teaching opportunities relevant to educators’ open educational resource (OER) engagement are proposed in this document.
Hood, Nina, Littlejohn, Allison
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Akademische Lehre braucht mehr "Open Educational Practices" für den Umgang mit "Open Educational Resources" - ein Plädoyer

Zeitschrift für Hochschulentwicklung, 2013
Der Beitrag knüpft an die vorherrschende sozio-technische Debatte um die freie Zugänglichkeit von digitalen Ressourcen oder Bildungsmaterialien an und erweitert diese hinsichtlich ihrer medienpädagogischen Gehalte, indem ein mediendidaktischer ...
Kerstin Mayrberger, Sandra Hofhues
doaj   +1 more source

Innovating Pedagogy 2015: Open University Innovation Report 4 [PDF]

, 2015
This series of reports explores new forms of teaching, learning and assessment for an interactive world, to guide teachers and policy makers in productive innovation.
Adams, Anne, Alozie, N, Ferguson, Rebecca, FitzGerald, Elizabeth, Gaved, Mark, McAndrew, Patrick, Means, B, Remold, J, Rienties, Bart, Roschelle, J, Sharples, Mike, Vogt, K, Whitelock, Denise, Yarnall, L   +13 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The community café: open practice with community-based language teachers

, 2013
This book is an edited collection of examples of good practice in using open education in the language classroom. The publication arose from the two-day conference “Learning through Sharing: Open Resources, Open Practices, Open Communication” organised ...
Borthwick, Kate, Dickens, Alison
core   +1 more source