Results 81 to 90 of about 1,287,785 (343)

Molecular cloning and characterization of a novel microsomal oleate desaturase gene DiFAD2 from Davidia involucrata Baill

Biologia Plantarum, 2010
In the conversion of oleic acid to linoleic acid, δ12-fatty acid desaturase (δ12-FAD) is involved. Based on the conserved oligo amino acid residues of the FAD2 genes from other plants, a new full-length cDNA (DiFAD2) encoding a δ12-FAD was cloned from ...
N. Lei, S. Peng, B. Niu, J. Chen, J. Zhou, L. Tang, Y. Xu, S. Wang, F. Chen   +8 more
doaj   +1 more source

Molecular cloning, characterization, and expression of two 5-HTRs from the pearl oyster Pinctada fucata martensii

Frontiers in Marine Science, 2022
The receptors of serotonin, also known as 5-hydroxytryptamine receptor (5-HTR) can mediate regulatory metamorphosis processes in a variety of mollusks.
Shaojie Zhu, Yubo He, Qiongyu Xu, Jiabin Zhang, Chuangye Yang, Ruijuan Hao, Junhui Li, Yuewen Deng, Yuewen Deng, Yuewen Deng, Yuewen Deng   +10 more
doaj   +1 more source

Classification and function of small open reading frames [PDF]

Nature Reviews Molecular Cell Biology, 2017
Small open reading frames (smORFs) of 100 codons or fewer are usually - if arbitrarily - excluded from proteome annotations. Despite this, the genomes of many metazoans, including humans, contain millions of smORFs, some of which fulfil key physiological functions. Recently, the transcriptome of Drosophila melanogaster was shown to contain thousands of
Couso, Juan Pablo, Patraquim, Pedro
openaire   +3 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]

, 2000
The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge, Chevalier, Catherine, Ielpi, Luis, Labigne, Agnès, O'Rourke, Eyleen J., Radicella, Juan Pablo   +5 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly

Nature Communications, 2020
Small open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory ...
Shan Zhang, Boris Reljić, Chao Liang, Baptiste Kerouanton, Joel Celio Francisco, Jih Hou Peh, Camille Mary, Narendra Suhas Jagannathan, Volodimir Olexiouk, Claire Tang, Gio Fidelito, Srikanth Nama, Ruey-Kuang Cheng, Caroline Lei Wee, Loo Chien Wang, Paula Duek Roggli, Prabha Sampath, Lydie Lane, Enrico Petretto, Radoslaw M. Sobota, Suresh Jesuthasan, Lisa Tucker-Kellogg, Bruno Reversade, Gerben Menschaert, Lei Sun, David A. Stroud, Lena Ho   +26 more
doaj   +1 more source

An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1

Frontiers in Genetics, 2020
Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipogenesis. The PPARγ gene produces various transcripts with different 5′-untranslated regions (5′ UTRs) because of alternative promoter usage and splicing.
Yankai Chu, Yankai Chu, Yankai Chu, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Guangwei Ma, Guangwei Ma, Guangwei Ma, Tingting Cui, Tingting Cui, Tingting Cui, Xiaohong Yan, Xiaohong Yan, Xiaohong Yan, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +20 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A Novel pH-Regulated, Unusual 603 bp Overlapping Protein Coding Gene pop Is Encoded Antisense to ompA in Escherichia coli O157:H7 (EHEC)

Frontiers in Microbiology, 2020
Antisense transcription is well known in bacteria. However, translation of antisense RNAs is typically not considered, as the implied overlapping coding at a DNA locus is assumed to be highly improbable.
Barbara Zehentner, Zachary Ardern, Michaela Kreitmeier, Siegfried Scherer, Siegfried Scherer, Klaus Neuhaus, Klaus Neuhaus   +6 more
doaj   +1 more source