Results 81 to 90 of about 1,409,999 (372)

Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia

RNA: A publication of the RNA Society, 2013
This study examines translational regulation of erythropoietin (EPO). New findings show that EPO translation is controlled by an upstream small open reading frame (ORF). In unstressed cells, the ORF represses translation.
C. Barbosa, L. Romão
semanticscholar   +1 more source

Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC [PDF]

, 1988
Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3' orf, in addition to the structural genes gag, pol, and env.
Hahn, Beatrice H., Hood, Leroy E., Jameson, Bradford A., Kappes, John C., Kent, Stephen B. H., Lee, Shei-Wen, Morrow, Casey D., Shaw, George M.   +7 more
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Peptidomic discovery of short open reading frame-encoded peptides in human cells [PDF]

, 2014
The amount of the transcriptome that is translated into polypeptides is of fundamental importance. We developed a peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells. We identified 90 SEPs, 86 of which are novel, the
Budnik, Bogdan A., Cabili, Moran N., Karger, Amir, Levin, Joshua Z., Ma, Jiao, Mitchell, Andrew J., Rinn, John L., Saghatelian, Alan, Schwaid, Adam G., Slavoff, Sarah A.   +9 more
core   +1 more source

Regulation of mRNA translation by a photoriboswitch. [PDF]

, 2020
Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are needed for spatiotemporal control of gene expression.
Abdelsayed, Michael M, Chamberlin, A Richard, Chizzolini, Fabio, Luptak, Andrej, Míšek, Jiří, Passalacqua, Luiz Fm, Rotstan, Kelly A, Sudarshan, Kasireddy   +7 more
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Extensive Transcript Diversity and Novel Upstream Open Reading Frame Regulation in Yeast

G3: Genes, Genomes, Genetics, 2013
To understand the diversity of transcripts in yeast (Saccharomyces cerevisiae) we analyzed the transcriptional landscapes for cells grown under 18 different environmental conditions.
Karl Waern, Michael P. Snyder
semanticscholar   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
AHN H.-J., BARBULESCU K., Bernd Kaspers, Daniela Baeuerle, DINARELLO C.A., DING A.H., Florian Puehler, HYODO Y., Kirsten C. Weining, Kirsten Schneider, MARTIN A., Peter Staeheli, Sandra Elvers, SUNDICK R.S.   +13 more
core   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Quantitative sequence and open reading frame analysis based on codon bias [PDF]

Journal of Systemics, Cybernetics and Informatics, 2006
The frequencies with which the sixty-four codons occur in human coding DNA are known. If we assume that the codons occur randomly, subject only to these probabilities, then it is possible to predict trinucleotide frequencies in each of the five other ...
Susan Rainey, Joe Repka
doaj