Results 1 to 10 of about 640,835 (387)

Trends and Geographic Patterns in Drug and Synthetic Opioid Overdose Deaths — United States, 2013–2019

MMWR. Morbidity and mortality weekly report, 2021
Deaths involving synthetic opioids other than methadone (synthetic opioids), which largely consist of illicitly manufactured fentanyl; psychostimulants with abuse potential (e.g., methamphetamine); and cocaine have increased in recent years, particularly
C. Mattson, Lauren J Tanz, K. Quinn, M. Kariisa, Priyam Patel, N. Davis   +5 more
semanticscholar   +1 more source

Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination—the SPIRAL study

Trials, 2023
Background Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are difficult to wean. As an alternative,
Cornelis Jan van Dam, Monique van Velzen, Cornelis Kramers, Arnt Schellekens, Erik Olofsen, Marieke Niesters, Albert Dahan   +6 more
doaj   +1 more source

The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis

Current Opinion in Psychiatry, 2021
Purpose of review This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment.
D. Ciccarone
semanticscholar   +1 more source

Extension for Community Healthcare Outcomes (ECHO) Chronic Pain & Opioid Stewardship in Northwestern Ontario: A Thematic Analysis of Patient Cases

Canadian Journal of Pain, 2022
Background Chronic pain (CP) is a debilitating disease that reduces quality of life, decreases productivity, and has become a primary cause of health care resource consumption.
Patricia A. Poulin, Yaadwinder Shergill, Adrian Grebowicz, Inês Almeida, Rosemee Cantave, Bryan MacLeod, Tim Larocque, Donna Garstin, Sarah F. Fitzgerald, Joshua A. Rash   +9 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy

Clinical pharmacology and therapy, 2021
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone).
K. Crews, A. Monte, Rachel Huddart, K. Caudle, E. Kharasch, A. Gaedigk, H. Dunnenberger, J. Leeder, J. Callaghan, C. Samer, T. Klein, Cyrine E. Haidar, S. V. Van Driest, G. Ruaño, K. Sangkuhl, L. Cavallari, D. Müller, C. Prows, M. Nagy, A. Somogyi, T. Skaar   +20 more
semanticscholar   +1 more source

HealthCare educational differences in pain management, adverse childhood experiences and their relationship to substance use disorder education

Substance Abuse Treatment, Prevention, and Policy, 2022
Background In order to assist the State of Ohio in the United States in addressing the opioid epidemic, the Ohio Attorney General appointed experts in a variety of academic disciplines to the Scientific Committee on Opioid Prevention and Education (SCOPE)
Myriam Shaw Ojeda, Aleda M. H. Chen, Tessa Miracle, Elizabeth Delaney, Caroline E. Freiermuth, Jon E. Sprague   +5 more
doaj   +1 more source

Drug and Opioid-Involved Overdose Deaths — United States, 2017–2018

MMWR. Morbidity and mortality weekly report, 2020
Of the 70,237 drug overdose deaths in the United States in 2017, approximately two thirds (47,600) involved an opioid (1). In recent years, increases in opioid-involved overdose deaths have been driven primarily by deaths involving synthetic opioids ...
N. Wilson, M. Kariisa, P. Seth, Herschel Smith, N. Davis   +4 more
semanticscholar   +1 more source

Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs

Substance Abuse Treatment, Prevention, and Policy, 2023
Background Medications for opioid use disorder (MOUD; methadone, buprenorphine, naltrexone) are the most effective treatments for OUD, and MOUD is protective against fatal overdoses.
Jaclyn M. W. Hughto, Abigail Tapper, Sabrina S. Rapisarda, Thomas J. Stopka, Wilson R. Palacios, Patricia Case, Joseph Silcox, Patience Moyo, Traci C. Green   +8 more
doaj   +1 more source

Efficacy of Transversus Abdominis Plane Block in the Reduction of Pain and Opioid Requirement in Laparoscopic and Robot-assisted Hysterectomy: A Systematic Review and Meta-analysis [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2022
Objective To summarize the available evidence of TAP Block in efficacy in laparoscopic or robotic hysterectomy. Data Sources We searched databases and gray literature for randomized controlled trials in which transversus abdominis plane (TAP) block ...
Claudia López-Ruiz, Jerutsa Catalina Orjuela, Diego Fernando Rojas-Gualdrón, Marcela Jimenez-Arango, José Fernando de los Ríos, Elsa Maria Vásquez-Trespalacios, Claudia Vargas   +6 more
doaj   +1 more source

Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder

JAMA Network Open, 2020
This comparative effectiveness research study examines associations between opioid use disorder treatment pathways and overdose and opioid-related acute care use as proxies for opioid use disorder recurrence.
S. Wakeman, Marc R. Larochelle, O. Ameli, C. Chaisson, J. Mcpheeters, W. Crown, F. Azocar, Darshak M Sanghavi   +7 more
semanticscholar   +1 more source