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MMWR. Morbidity and mortality weekly report, 2021 Deaths involving synthetic opioids other than methadone (synthetic opioids), which largely consist of illicitly manufactured fentanyl; psychostimulants with abuse potential (e.g., methamphetamine); and cocaine have increased in recent years, particularly
C. Mattson +5 more
semanticscholar +1 more source
Trials, 2023 Background Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are difficult to wean. As an alternative,
Cornelis Jan van Dam +6 more
doaj +1 more source
The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis
Current Opinion in Psychiatry, 2021 Purpose of review This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment.
D. Ciccarone
semanticscholar +1 more source
Canadian Journal of Pain, 2022 Background Chronic pain (CP) is a debilitating disease that reduces quality of life, decreases productivity, and has become a primary cause of health care resource consumption.
Patricia A. Poulin +9 more
doaj +1 more source
Clinical pharmacology and therapy, 2021 Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone).
K. Crews +20 more
semanticscholar +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2022 Background In order to assist the State of Ohio in the United States in addressing the opioid epidemic, the Ohio Attorney General appointed experts in a variety of academic disciplines to the Scientific Committee on Opioid Prevention and Education (SCOPE)
Myriam Shaw Ojeda +5 more
doaj +1 more source
Drug and Opioid-Involved Overdose Deaths — United States, 2017–2018
MMWR. Morbidity and mortality weekly report, 2020 Of the 70,237 drug overdose deaths in the United States in 2017, approximately two thirds (47,600) involved an opioid (1). In recent years, increases in opioid-involved overdose deaths have been driven primarily by deaths involving synthetic opioids ...
N. Wilson +4 more
semanticscholar +1 more source
Patterns of Routes of Administration and Drug Tampering for Nonmedical Opioid Consumption: Data Mining and Content Analysis of Reddit Discussions [PDF]
J Med Internet Res 2021;23(1):e21212, 2021 The complex unfolding of the US opioid epidemic in the last 20 years has been the subject of a large body of medical and pharmacological research, and it has sparked a multidisciplinary discussion on how to implement interventions and policies to effectively control its impact on public health.
arxiv +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2023 Background Medications for opioid use disorder (MOUD; methadone, buprenorphine, naltrexone) are the most effective treatments for OUD, and MOUD is protective against fatal overdoses.
Jaclyn M. W. Hughto +8 more
doaj +1 more source
The challenge of perioperative pain management in opioid-tolerant patients [PDF]
, 2017 The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F +9 more
core +6 more sources