Results 1 to 10 of about 577,246 (314)

An opioid-like system regulating feeding behavior in C. elegans [PDF]

open access: yeseLife, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Mi Cheong Cheong   +3 more
doaj   +4 more sources

Trends and Geographic Patterns in Drug and Synthetic Opioid Overdose Deaths — United States, 2013–2019

open access: yesMMWR. Morbidity and mortality weekly report, 2021
Deaths involving synthetic opioids other than methadone (synthetic opioids), which largely consist of illicitly manufactured fentanyl; psychostimulants with abuse potential (e.g., methamphetamine); and cocaine have increased in recent years, particularly
C. Mattson   +5 more
semanticscholar   +1 more source

Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination—the SPIRAL study

open access: yesTrials, 2023
Background Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are difficult to wean. As an alternative,
Cornelis Jan van Dam   +6 more
doaj   +1 more source

The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis

open access: yesCurrent Opinion in Psychiatry, 2021
Purpose of review This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment.
D. Ciccarone
semanticscholar   +1 more source

Extension for Community Healthcare Outcomes (ECHO) Chronic Pain & Opioid Stewardship in Northwestern Ontario: A Thematic Analysis of Patient Cases

open access: yesCanadian Journal of Pain, 2022
Background Chronic pain (CP) is a debilitating disease that reduces quality of life, decreases productivity, and has become a primary cause of health care resource consumption.
Patricia A. Poulin   +9 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy

open access: yesClinical pharmacology and therapy, 2021
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone).
K. Crews   +20 more
semanticscholar   +1 more source

HealthCare educational differences in pain management, adverse childhood experiences and their relationship to substance use disorder education

open access: yesSubstance Abuse Treatment, Prevention, and Policy, 2022
Background In order to assist the State of Ohio in the United States in addressing the opioid epidemic, the Ohio Attorney General appointed experts in a variety of academic disciplines to the Scientific Committee on Opioid Prevention and Education (SCOPE)
Myriam Shaw Ojeda   +5 more
doaj   +1 more source

Drug and Opioid-Involved Overdose Deaths — United States, 2017–2018

open access: yesMMWR. Morbidity and mortality weekly report, 2020
Of the 70,237 drug overdose deaths in the United States in 2017, approximately two thirds (47,600) involved an opioid (1). In recent years, increases in opioid-involved overdose deaths have been driven primarily by deaths involving synthetic opioids ...
N. Wilson   +4 more
semanticscholar   +1 more source

Patterns of Routes of Administration and Drug Tampering for Nonmedical Opioid Consumption: Data Mining and Content Analysis of Reddit Discussions [PDF]

open access: yesJ Med Internet Res 2021;23(1):e21212, 2021
The complex unfolding of the US opioid epidemic in the last 20 years has been the subject of a large body of medical and pharmacological research, and it has sparked a multidisciplinary discussion on how to implement interventions and policies to effectively control its impact on public health.
arxiv   +1 more source

Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs

open access: yesSubstance Abuse Treatment, Prevention, and Policy, 2023
Background Medications for opioid use disorder (MOUD; methadone, buprenorphine, naltrexone) are the most effective treatments for OUD, and MOUD is protective against fatal overdoses.
Jaclyn M. W. Hughto   +8 more
doaj   +1 more source

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