Results 21 to 30 of about 593,453 (414)

New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults

JAMA Surgery, 2017
Importance Despite increased focus on reducing opioid prescribing for long-term pain, little is known regarding the incidence and risk factors for persistent opioid use after surgery.
C. Brummett, J. Waljee, J. Goesling, Stephanie E. Moser, Paul Lin, M. Englesbe, A. Bohnert, S. Kheterpal, B. Nallamothu   +8 more
semanticscholar   +1 more source

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery

Anesthesiology, 2021
Background: It is speculated that opioid-free anesthesia may provide adequate pain control while reducing postoperative opioid consumption. However, there is currently no evidence to support the speculation.
H. Beloeil, M. Garot, G. Lebuffe, Alexandre Gerbaud, Julien Bila, P. Cuvillon, Elisabeth Dubout, S. Oger, J. Nadaud, A. Bécret, Nicolas Coullier, Sylvain Lecoeur, Julie Fayon, T. Godet, M. Mazerolles, F. Atallah, S. Sigaut, Pierre-Marie Choinier, K. Asehnoune, A. Roquilly, G. Chanques, M. Esvan, E. Futier, B. Laviolle   +23 more
semanticscholar   +1 more source

Ru complexes containing N‐methyl‐1,3,5‐triaza‐7‐phosphaadamantane (mPTA) as catalysts for the isomerization of 2‐cyclohexen‐1‐ol

Applied Organometallic Chemistry, Volume 37, Issue 2, February 2023., 2023
The paper discusses the catalytic activity of [RuCp(H2O‐κO)(mPTA)2](CF3SO3)3 for the isomerization of the cyclic allylic alcohol 2‐cyclohexen‐1‐ol with good conversion and negligible metal losses. The complex [RuCp(H2O‐κO)(mPTA)2](CF3SO3)3·MeOH (4·MeOH) was synthesized and characterized by spectroscopic techniques and its crystal structure determined ...
Belén López‐Sánchez, Ana Belén Bohome‐Espinosa, Franco Scalambra, Antonio Romerosa   +3 more
wiley   +1 more source

Safety of opioid patch initiation in Australian residential aged care [PDF]

, 2015
Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Elizabeth Roughead, Lisa Pont, Svetla Gadzhanova   +2 more
core   +1 more source

Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus

The Anatomical Record, Volume 306, Issue 1, Page 162-175, January 2023., 2023
Abstract An adverse maternal environment (AME) and Western diet (WD) in early life predispose offspring toward cognitive impairment in humans and mice. Cognitive impairment associates with hippocampal dysfunction. An important regulator of hippocampal function is the hippocampal Nociceptin/Orphanin FQ (N/OFQ) system. Previous studies find links between
Xingrao Ke, Yingliu Huang, Qi Fu, Amber Majnik, Venkatesh Sampath, Robert H. Lane   +5 more
wiley   +1 more source

Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies

British medical journal, 2017
Objective To compare the risk for all cause and overdose mortality in people with opioid dependence during and after substitution treatment with methadone or buprenorphine and to characterise trends in risk of mortality after initiation and cessation of ...
L. Sordo, G. Barrio, M. Bravo, Iciar B Indave, L. Degenhardt, L. Wiessing, M. Ferri, R. Pastor-Barriuso   +7 more
semanticscholar   +1 more source

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran, Rosaria Gitto   +4 more
wiley   +1 more source

An integrated abundance model for estimating county-level prevalence of opioid misuse in Ohio [PDF]

Journal of the Royal Statistical Society Series A: Statistics in Society. 2023;186(1):43-60, 2021
Opioid misuse is a national epidemic and a significant drug related threat to the United States. While the scale of the problem is undeniable, estimates of the local prevalence of opioid misuse are lacking, despite their importance to policy-making and resource allocation.
arxiv   +1 more source

3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco, Antonio Laus, Maksims Vanejevs, Anastasija Ture, Rafaela Mostallino, Nicholas Pintori, Maria Antonietta De Luca, M. Paola Castelli, Gaetano Di Chiara   +8 more
wiley   +1 more source

Comparative Efficacy of Two Different Dosages of Intrathecal Magnesium Sulphate Supplementation in Subarachnoid Block [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Spinal anaesthesia is the primary anaesthetic technique for many types of surgeries. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects like respiratory depression, urinary retention ...
Binesh Kathuria, Neeru Luthra, Aanchal Gupta, Anju Grewal, Dinesh Sood   +4 more
doaj   +1 more source