Results 21 to 30 of about 697,718 (358)
Anesthesiology, 2021 Background: It is speculated that opioid-free anesthesia may provide adequate pain control while reducing postoperative opioid consumption. However, there is currently no evidence to support the speculation.
H. Beloeil +23 more
semanticscholar +1 more source
Increases in Drug and Opioid Overdose Deaths--United States, 2000-2014.
MMWR. Morbidity and mortality weekly report, 2016 The United States is experiencing an epidemic of drug overdose (poisoning) deaths. Since 2000, the rate of deaths from drug overdoses has increased 137%, including a 200% increase in the rate of overdose deaths involving opioids (opioid pain relievers ...
R. A. Rudd +3 more
semanticscholar +2 more sources
British medical journal, 2017 Objective To compare the risk for all cause and overdose mortality in people with opioid dependence during and after substitution treatment with methadone or buprenorphine and to characterise trends in risk of mortality after initiation and cessation of ...
L. Sordo +7 more
semanticscholar +1 more source
An opioid-like system regulating feeding behavior in C. elegans [PDF]
, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B. +3 more
core +3 more sources
Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort [PDF]
Epidemiology and Health, 2022 OBJECTIVES Opioids are prescribed to treat moderate to severe pain. We investigated recent trends in opioid (morphine, oxycodone, fentanyl, and hydromorphone) prescriptions using data from the Korean National Health Insurance Service-National Sample ...
Joungyoun Kim +8 more
doaj +1 more source
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources
Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
Pharmaceuticals, 2021 Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse ...
A. Paul +7 more
semanticscholar +1 more source
Molecules, 2021 In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity.
Nazlı Turan Yücel +5 more
doaj +1 more source
Postoperative opioid use following head and neck endocrine surgery: A multi‐center prospective study
Laryngoscope Investigative Otolaryngology, 2023 Background Opioid abuse is widespread in North America and the over‐prescription of opioids are a contributing factor. The goal of this prospective study was to quantify over‐prescription rates, evaluate postoperative experiences of pain, and understand ...
Amr F. Hamour +9 more
doaj +1 more source
Pharmaceutics, 2022 Moderate to severe cancer pain treatment in children is based on the use of weak and strong opioids. Pharmacogenetics play a central role in developing personalized pain therapies, as well as avoiding treatment failure and/or intolerable adverse drug ...
Giada Crescioli +14 more
doaj +1 more source