Results 31 to 40 of about 640,835 (387)
The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.
Annual Review of Public Health, 2015 Public health authorities have described, with growing alarm, an unprecedented increase in morbidity and mortality associated with use of opioid pain relievers (OPRs).
Andrew J. Kolodny +6 more
semanticscholar +1 more source
An opioid-like system regulating feeding behavior in C. elegans [PDF]
, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B. +3 more
core +3 more sources
Annals of MedicineBackground The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ...
Kim A. Hoffman +7 more
doaj +1 more source
Framing Science: How Opioid Research Is Presented in Online News Media
Frontiers in Communication, 2020 Popular news media play an instrumental role in shaping public perception of issues like the opioid crisis. Using a detailed coding instrument, we analyzed how opioid-related scholarly publications were covered in 149 news stories published by nine major
Lisa Matthias +5 more
doaj +1 more source
Addiction Science & Clinical Practice, 2019 Background The study examined the association of the Affordable Care Act’s 2014 Medicaid expansion on the use of psychosocial services and pharmacotherapies for opioid use disorders among Oregon Medicaid recipients.
Dennis McCarty +3 more
doaj +1 more source
The Changing Opioid Crisis: development, challenges and opportunities
Molecular Psychiatry, 2020 The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes. This review examines the origin and evolution of
N. Volkow, C. Blanco
semanticscholar +1 more source
Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
Pharmaceuticals, 2021 Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse ...
A. Paul +7 more
semanticscholar +1 more source
Roles of the ubiquitin proteasome system in the effects of drugs of abuse
Frontiers in Molecular Neuroscience, 2015 Because of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of learning and memory depend on UPS activity.
Nicolas eMassaly +6 more
doaj +1 more source
Science Signaling, 2020 Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists. Opioids: Efficacy versus bias Because of its antinociceptive effects, the μ-opioid receptor (MOR) is an important target for pain management, but
A. Gillis +21 more
semanticscholar +1 more source
The Association Between Opioid-Related Industry Payments and Opioid Prescribing at the Individual and Ecological Level in Pennsylvania [PDF]
, 2018 Objective: to understand how industry payments related to opioid products are associated with opioid prescribing in Pennsylvania. Methods: we merged the Open Payments data, Medicare Part D public use file, and Dartmouth Hospital Atlas of Health Care ...
George, PhD, MS, Brandon +2 more
core +1 more source