British medical journal, 2017 Objective To compare the risk for all cause and overdose mortality in people with opioid dependence during and after substitution treatment with methadone or buprenorphine and to characterise trends in risk of mortality after initiation and cessation of ...
L. Sordo +7 more
semanticscholar +1 more source
The Changing Opioid Crisis: development, challenges and opportunities
Molecular Psychiatry, 2020 The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes. This review examines the origin and evolution of
N. Volkow, C. Blanco
semanticscholar +1 more source
Comparative Efficacy of Two Different Dosages of Intrathecal Magnesium Sulphate Supplementation in Subarachnoid Block [PDF]
Journal of Clinical and Diagnostic Research, 2014 Background: Spinal anaesthesia is the primary anaesthetic technique for many types of surgeries. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects like respiratory depression, urinary retention ...
Binesh Kathuria +4 more
doaj +1 more source
An opioid-like system regulating feeding behavior in C. elegans [PDF]
, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B. +3 more
core +3 more sources
Opioid Use Disorder Documented at Delivery Hospitalization — United States, 1999–2014
MMWR. Morbidity and mortality weekly report, 2018 Opioid use by pregnant women represents a significant public health concern given the association of opioid exposure and adverse maternal and neonatal outcomes, including preterm labor, stillbirth, neonatal abstinence syndrome, and maternal mortality (1 ...
Sarah C. Haight +4 more
semanticscholar +1 more source
Development of an integrated cognitive behavioral therapy for anxiety and opioid use disorder: Study protocol and methods [PDF]
, 2017 Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based
Barlow, David H. +5 more
core +1 more source
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources
Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality
Annals of Internal Medicine, 2018 The United States is in the midst of a crisis of opioid-related harms (1). Some efforts to address this crisis focus on expanding access to effective treatment of opioid use disorders (OUDs) (2).
Marc R. Larochelle +8 more
semanticscholar +1 more source
Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model
Frontiers in Pharmacology, 2021 Newborns exposed to prenatal opioids often experience intense postnatal withdrawal after cessation of the opioid, called neonatal opioid withdrawal syndrome (NOWS), with limited pre- and postnatal therapeutic options available.
Alireza Safa +14 more
doaj +1 more source
Opioid Crisis: No Easy Fix to Its Social and Economic Determinants.
American Journal of Public Health, 2018 The accepted wisdom about the US overdose crisis singles out prescribing as the causative vector. Although drug supply is a key factor, we posit that the crisis is fundamentally fueled by economic and social upheaval, its etiology closely linked to the ...
N. Dasgupta, L. Beletsky, D. Ciccarone
semanticscholar +1 more source