Results 41 to 50 of about 697,718 (358)

Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse

Frontiers in Molecular Biosciences, 2023
Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A ...
Margaret J. Fuller, Margaret J. Fuller, Margaret J. Fuller, Margaret J. Fuller, Subhash C. Gupta, Subhash C. Gupta, Rong Fan, Rong Fan, Rebecca J. Taugher-Hebl, Rebecca J. Taugher-Hebl, Grace Z. Wang, Grace Z. Wang, Noah R. R. Andrys, Noah R. R. Andrys, Amal K. Bera, Jason J. Radley, John A. Wemmie, John A. Wemmie, John A. Wemmie, John A. Wemmie, John A. Wemmie, John A. Wemmie, John A. Wemmie   +22 more
doaj   +1 more source

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis

British medical journal, 2021
Objective To assess the effectiveness and safety of different preparations and doses of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and paracetamol for knee and hip osteoarthritis pain and physical function to enable effective and safe use ...
B. R. da Costa, T. V. Pereira, P. Saadat, Martina Rudnicki, S. Iskander, N. Bodmer, Pavlos Bobos, Lilian Gao, H. Kiyomoto, T. Montezuma, M. Almeida, P. Cheng, C. Hincapié, R. Hari, A. Sutton, P. Tugwell, G. Hawker, P. Jüni   +17 more
semanticscholar   +1 more source

Engaging the Great Circle: a qualitative study of the Confederated Tribes of Grand Ronde’s mobile medication unit

Annals of Medicine
Background The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ...
Kim A. Hoffman, Chantell Graves, Kelly Rowe, Jennifer Worth, Kellie Pertl, James Laidler, P. Todd Korthuis, Dennis McCarty   +7 more
doaj   +1 more source

Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use — United States, 2006–2015

MMWR. Morbidity and mortality weekly report, 2017
Because long-term opioid use often begins with treatment of acute pain (1), in March 2016, the CDC Guideline for Prescribing Opioids for Chronic Pain included recommendations for the duration of opioid therapy for acute pain and the type of opioid to ...
Anuj Shah, C. Hayes, B. Martin
semanticscholar   +1 more source

Pain management in hospitalized patients with long term opioid use [PDF]

Trends in Pharmaceutical Sciences, 2019
This study aims to provide a discussion on pain management challenges in opium addict patients. Pain and addiction are complicated with each other, and their managing requires more clinical consideration.
laleh mahmoudi, soha Azadi
doaj   +1 more source

The Association Between Opioid-Related Industry Payments and Opioid Prescribing at the Individual and Ecological Level in Pennsylvania [PDF]

, 2018
Objective: to understand how industry payments related to opioid products are associated with opioid prescribing in Pennsylvania. Methods: we merged the Open Payments data, Medicare Part D public use file, and Dartmouth Hospital Atlas of Health Care ...
George, PhD, MS, Brandon, King, MPHc, John Henri, McIntire, PhD, MPH, Russell K.   +2 more
core   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

Medicaid expansion and treatment for opioid use disorders in Oregon: an interrupted time-series analysis

Addiction Science & Clinical Practice, 2019
Background The study examined the association of the Affordable Care Act’s 2014 Medicaid expansion on the use of psychosocial services and pharmacotherapies for opioid use disorders among Oregon Medicaid recipients.
Dennis McCarty, Yifan Gu, John W. McIlveen, Bonnie K. Lind   +3 more
doaj   +1 more source

The genomics of neonatal abstinence syndrome [PDF]

, 2017
Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids.
Cole, F. Sessions, Davis, Jonathan M, Wegner, Daniel J   +2 more
core   +3 more sources

Structure of the μ Opioid Receptor-Gi Protein Complex

Nature, 2018
The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive effects of analgesia and euphoria are mediated by μOR signalling through the adenylyl cyclase ...
A. Koehl, Hongli Hu, S. Maeda, Yan Zhang, Q. Qu, Joseph M. Paggi, Naomi R. Latorraca, D. Hilger, R. Dawson, H. Matile, G. Schertler, S. Granier, W. Weis, R. Dror, A. Manglik, G. Skiniotis, B. Kobilka   +16 more
semanticscholar   +1 more source