Results 41 to 50 of about 659,970 (390)

The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.

Annual Review of Public Health, 2015
Public health authorities have described, with growing alarm, an unprecedented increase in morbidity and mortality associated with use of opioid pain relievers (OPRs).
Andrew J. Kolodny, D. Courtwright, Catherine S. Hwang, P. Kreiner, John L. Eadie, Thomas W. Clark, G. Alexander   +6 more
semanticscholar   +1 more source

Opioid Analgesia and Opioid-Induced Adverse Effects: A Review

Pharmaceuticals, 2021
Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse ...
A. Paul, Craig M. Smith, M. Rahmatullah, V. Nissapatorn, P. Wilairatana, M. Spetea, N. Gueven, N. Dietis   +7 more
semanticscholar   +1 more source

Efficacy of PECS block in addition to multimodal analgesia for postoperative pain management in patients undergoing outpatient elective breast surgery: A retrospective study

Frontiers in Medicine, 2022
BackgroundPectoralis nerve blocks (PECS) have been shown in numerous studies to be a safe and effective method to treat postoperative pain and reduce postoperative opioid consumption after breast surgery.
Alberto A. Uribe, Tristan E. Weaver, Marco Echeverria-Villalobos, Luis Periel, Joshua Pasek, Juan Fiorda-Diaz, Marilly Palettas, Roman J. Skoracki, Stephen J. Poteet, Jarrett A. Heard   +9 more
doaj   +1 more source

The Rural Opioid Initiative Consortium description: providing evidence to Understand the Fourth Wave of the Opioid Crisis

Addiction Science & Clinical Practice, 2022
Objective To characterize and address the opioid crisis disproportionately impacting rural U.S. regions. Methods The Rural Opioid Initiative (ROI) is a two-phase project to collect and harmonize quantitative and qualitative data and develop tailored ...
R. Jenkins, B. Whitney, R. Nance, Todd M. Allen, H. Cooper, J. Feinberg, R. Fredericksen, P. Friedmann, V. Go, W. Jenkins, P. Korthuis, W. Miller, M. Pho, A. Rudolph, D. Seal, Gordon S. Smith, T. Stopka, R. Westergaard, A. Young, W. Zule, J. Delaney, J. Tsui, H. Crane, the Rural Opioid Initiative   +23 more
semanticscholar   +1 more source

Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

eLife, 2022
Pain perception is decreased by shifting attentional focus away from a threatening event. This attentional analgesia engages parallel descending control pathways from anterior cingulate (ACC) to locus coeruleus, and ACC to periaqueductal grey (PAG ...
Valeria Oliva, Ron Hartley-Davies, Rosalyn Moran, Anthony E Pickering, Jonathan CW Brooks   +4 more
doaj   +1 more source

Opioid Analgesic Prescribing Practices of Dental Professionals in the United States [PDF]

, 2017
The prescription of opioid analgesics by dental professionals is widespread in the United States. Policy makers, government agencies, and professional organizations consider this phenomenon a growing public health concern.
Okunseri, Christopher, Okunseri, Elaye, Steinmetz, C. N., Szabo, Aniko, Zheng, C.   +4 more
core   +2 more sources

Structure of the μ Opioid Receptor-Gi Protein Complex

Nature, 2018
The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive effects of analgesia and euphoria are mediated by μOR signalling through the adenylyl cyclase ...
A. Koehl, Hongli Hu, S. Maeda, Yan Zhang, Q. Qu, Joseph M. Paggi, Naomi R. Latorraca, D. Hilger, R. Dawson, H. Matile, G. Schertler, S. Granier, W. Weis, R. Dror, A. Manglik, G. Skiniotis, B. Kobilka   +16 more
semanticscholar   +1 more source

Engaging the Great Circle: a qualitative study of the Confederated Tribes of Grand Ronde’s mobile medication unit

Annals of Medicine
Background The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ...
Kim A. Hoffman, Chantell Graves, Kelly Rowe, Jennifer Worth, Kellie Pertl, James Laidler, P. Todd Korthuis, Dennis McCarty   +7 more
doaj   +1 more source

Medicaid expansion and treatment for opioid use disorders in Oregon: an interrupted time-series analysis

Addiction Science & Clinical Practice, 2019
Background The study examined the association of the Affordable Care Act’s 2014 Medicaid expansion on the use of psychosocial services and pharmacotherapies for opioid use disorders among Oregon Medicaid recipients.
Dennis McCarty, Yifan Gu, John W. McIlveen, Bonnie K. Lind   +3 more
doaj   +1 more source

Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

eLife, 2021
An opioid epidemic is spreading in North America with millions of opioid overdoses annually. Opioid drugs, like fentanyl, target the mu opioid receptor system and induce potentially lethal respiratory depression.
Shenhab Zaig, Carolina da Silveira Scarpellini, Gaspard Montandon   +2 more
doaj   +1 more source