Results 51 to 60 of about 593,453 (414)
Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]
, 2017 Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun +2 more
core +2 more sources
Individualized Risk Assessment of Preoperative Opioid Use by Interpretable Neural Network Regression [PDF]
arXiv, 2022 Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative opioid use helps establish patient-centered pain management.
arxiv
Journal of the American Medical Association (JAMA), 2018 Importance Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. Objective To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and ...
E. Krebs +8 more
semanticscholar +1 more source
Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 5001-5012, December 2022., 2022 Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). To elucidate circulating stimulators for nerve invasion, the authors evaluated the stimulant activity and the inhibitory effects of IL‐6/gp130 axis. Biological activity of IL‐6/gp130 axis promoted nerve invasion in murine model and was upregulated in ...
Hidetaka Suzuki +9 more
wiley +1 more source
Annals of MedicineBackground The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ...
Kim A. Hoffman +7 more
doaj +1 more source
Indian Journal of Social Psychiatry, 2018 Context: Substance use disorder coexisting with other psychiatric disorders poses complex diagnostic and therapeutic challenges. Comorbidity is often associated with high rates of continued substance use, greater psychosocial impairment, and increased ...
Rakesh Mohanty +2 more
doaj +1 more source
Frontiers in Psychiatry, 2020 BackgroundObservational data and preliminary studies suggest serotonin 2A agonist psychedelics may hold potential in treating a variety of substance use disorders (SUDs), including opioid use disorder (OUD).AimsThe study aim was to describe and analyze ...
Albert Garcia-Romeu +7 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 The pharmacokinetics of butorphanol after intravenous (IVB) and intramuscular (IMB) administration in donkeys were determined in this preliminary study. Healthy male gelded donkeys (n = 5), aged 6–12 years old, were administered 0.1 mg/kg butorphanol IV ...
Lisa Ebner +9 more
doaj +1 more source
American Journal of Public Health, 2018 Objectives To compare US trends in rates of injection drug use (IDU), specifically opioid injection, with national trends in the incidence of acute HCV infection to assess whether these events correlated over time.
Jon E. Zibbell +6 more
semanticscholar +1 more source
Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
Pharmaceuticals, 2021 Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse ...
A. Paul +7 more
semanticscholar +1 more source